Free ultra-groups, generators and relations

In this paper, we intend to define an ultra-group by its presentation. The attitude of the presentation for a group was the key for us to investigate in this area. Instead of writing whole elements of an ultra-group, we denote it by its generators and the relations among those generators. A general computational approach for finitely presented ultra-groups by quotient ultra-groups and subultra-groups is described and some examples are presented. It is the way that can clarify the structure of an ultra-group quicker than having just a list of elements

In vivo killing of Staphylococcus aureus using a light-activated antimicrobial agent

Background: The widespread problem of antibiotic resistance in pathogens such as Staphylococcus aureus has prompted the search for new antimicrobial approaches. In this study we report for the first time the use of a light-activated antimicrobial agent, methylene blue, to kill an epidemic methicillin-resistant Staphylococcus aureus (EMRSA-16) strain in two mouse wound models.Results: Following irradiation of wounds with 360 J/cm(2) of laser light (670 nm) in the presence of 100 mu g/ml of methylene blue, a 25-fold reduction in the number of viable EMRSA was seen. This was independent of the increase in temperature of the wounds associated with the treatment. Histological examination of the wounds revealed no difference between the photodynamic therapy (PDT)-treated wounds and the untreated wounds, all of which showed the same degree of inflammatory infiltration at 24 hours.Conclusion: The results of this study demonstrate that PDT is effective at reducing the total number of viable EMRSA in a wound. This approach has promise as a means of treating wound infections caused by antibiotic-resistant microbes as well as for the elimination of such organisms from carriage sites

Beta carbonic anhydrases: novel targets for pesticides and anti-parasitic agents in agriculture and livestock husbandry

Abstract BACKGROUND: The genomes of many insect and parasite species contain beta carbonic anhydrase (β-CA) protein coding sequences. The lack of β-CA proteins in mammals makes them interesting target proteins for inhibition in treatment of some infectious diseases and pests. Many insects and parasites represent important pests for agriculture and cause enormous economic damage worldwide. Meanwhile, pollution of the environment by old pesticides, emergence of strains resistant to them, and their off-target effects are major challenges for agriculture and society. METHODS: In this study, we analyzed a multiple sequence alignment of 31 β-CAs from insects, some parasites, and selected plant species relevant to agriculture and livestock husbandry. Using bioinformatics tools a phylogenetic tree was generated and the subcellular localizations and antigenic sites of each protein were predicted. Structural models for β-CAs of Ancylostoma caninum, Ascaris suum, Trichinella spiralis, and Entamoeba histolytica, were built using Pisum sativum and Mycobacterium tuberculosis β-CAs as templates. RESULTS: Six β-CAs of insects and parasites and six β-CAs of plants are predicted to be mitochondrial and chloroplastic, respectively, and thus may be involved in important metabolic functions. All 31 sequences showed the presence of the highly conserved β-CA active site sequence motifs, CXDXR and HXXC (C: cysteine, D: aspartic acid, R: arginine, H: histidine, X: any residue). We discovered that these two motifs are more antigenic than others. Homology models suggested that these motifs are mostly buried and thus not well accessible for recognition by antibodies. CONCLUSIONS: The predicted mitochondrial localization of several β-CAs and hidden antigenic epitopes within the protein molecule, suggest that they may not be considered major targets for vaccines. Instead, they are promising candidate enzymes for small-molecule inhibitors which can easily penetrate the cell membrane. Based on current knowledge, we conclude that β-CAs are potential targets for development of small molecule pesticides or anti-parasitic agents with minimal side effects on vertebratesBioMed Central open acces

Beta carbonic anhydrases: novel targets for pesticides and anti-parasitic agents in agriculture and livestock husbandry

BACKGROUND: The genomes of many insect and parasite species contain beta carbonic anhydrase (&beta;-CA) protein coding sequences. The lack of &beta;-CA proteins in mammals makes them interesting target proteins for inhibition in treatment of some infectious diseases and pests. Many insects and parasites represent important pests for agriculture and cause enormous economic damage worldwide. Meanwhile, pollution of the environment by old pesticides, emergence of strains resistant to them, and their off-target effects are major challenges for agriculture and society. METHODS: In this study, we analyzed a multiple sequence alignment of 31 &beta;-CAs from insects, some parasites, and selected plant species relevant to agriculture and livestock husbandry. Using bioinformatics tools a phylogenetic tree was generated and the subcellular localizations and antigenic sites of each protein were predicted. Structural models for &beta;-CAs of Ancylostoma caninum, Ascaris suum, Trichinella spiralis, and Entamoeba histolytica, were built using Pisum sativum and Mycobacterium tuberculosis &beta;-CAs as templates. RESULTS: Six &beta;-CAs of insects and parasites and six &beta;-CAs of plants are predicted to be mitochondrial and chloroplastic, respectively, and thus may be involved in important metabolic functions. All 31 sequences showed the presence of the highly conserved &beta;-CA active site sequence motifs, CXDXR and HXXC (C: cysteine, D: aspartic acid, R: arginine, H: histidine, X: any residue). We discovered that these two motifs are more antigenic than others. Homology models suggested that these motifs are mostly buried and thus not well accessible for recognition by antibodies. CONCLUSIONS: The predicted mitochondrial localization of several &beta;-CAs and hidden antigenic epitopes within the protein molecule, suggest that they may not be considered major targets for vaccines. Instead, they are promising candidate enzymes for small-molecule inhibitors which can easily penetrate the cell membrane. Based on current knowledge, we conclude that &beta;-CAs are potential targets for development of small molecule pesticides or anti-parasitic agents with minimal side effects on vertebrates.</p

Modification of immobilized titanium dioxide nanostructures by argon plasma for photocatalytic removal of organic dyes

The aim of this study was to modify surface properties of immobilized rutile TiO 2 using Argon cold plasma treatment and to evaluate the performance of the catalyst in photocatalytic elimination of synthetic dyes in UV/TiO 2 /H 2 O 2 process. The surface-modified TiO 2 was characterized by XRD, EDX, SEM, UV-DRS and XPS analyses. Response surface methodology was adopted to achieve high catalyst efficiency by evaluating the effect of two main independent cold plasma treatment parameters (exposure time and pressure) on surface modification of the catalyst. The increase of the plasma operation pressure led to higher decolorization percentage, while the increase of plasma exposure time decreased the decolorization efficiency. RSM methodology predicted optimum plasma treatment conditions to be 0.78 Torr and 21 min of exposure time, which resulted in decolorization of 10 mg/L solution of the malachite green solution by 94.94 in 30 min. The plasma treatment decreased the oxygen to titanium ratio and caused oxygen vacancy on the surface of the catalyst, resulting in the superior performance of the plasma-treated catalyst. Pseudo first-order kinetic rate constant for the plasma-treated catalyst was 4.28 and 2.03 times higher than the rate constant for the non-treated photocatalyst in decolorization of aqueous solutions of malachite green and crystal violet, respectively. © 2019 by the authors

Type-2 fuzzy linear systems

Fuzzy Linear Systems (FLSs) are used in practical situations where some of the systems parameters or variables are uncertain. To date, investigations conducted on FLSs are restricted to those in which the uncertainty is assumed to be modeled by Type-1 Fuzzy Sets (T1FSs). However, there are many situations where considering the uncertainty as T1FSs may not be possible due to different interpretations of experts about the uncertainty. Moreover, solutions of FLSs are T1FSs which do not provide any information about a measure of the dispersion of uncertainty around the T1FSs. Therefore, in this research a model of uncertain linear equations system called a type-2 fuzzy linear system is presented to overcome the shortcomings. The uncertainty is represented by a special class of type-2 fuzzy sets – triangular perfect quasi type-2 fuzzy numbers. Additionally, conditions for the existence of a unique type–2 fuzzy solution to the linear system are derived. A definition of a type-2 fuzzy solution is also given. The applicability of the proposed model is illustrated using examples in the pulp and paper industry, and electrical engineering