Interview with Huda Zoghbi

An oral history interview with Dr. Huda Zoghbi about her career at Baylor College of Medicine in the Texas Medical Center. She worked as a professor in the Departments of Pediatrics, Molecular and Human Genetics, Neurology and Neuroscience at Baylor College of Medicine. She was also an investigator at the Howard Hughes Medical Institute and the director of the Jan and Dan Duncan Neurological Research Institute (NRI) at Texas Children\u27s Hospital. SOURCE: Baylor College of Medicine website, http://www.bcm.ed

Relativistic iron K X-ray Reverberation in NGC 4151

Recent X-ray observations have enabled the study of reverberation delays in AGN for the first time. All the detections so far are in sources with a strong soft excess, and the measured delay is between the hard (1-3 keV) direct continuum and the soft excess (0.5-1 keV), interpreted as the reflection continuum smeared by relativistic effects. There is however an inherent ambiguity in identifying and studying the details of the lines in the soft excess. Here we report the first detection of reverberation in the iron K band in any AGN. Using XMM-Newton observations of NGC 4151, we find delays of order 2000 s on time-scales of 10e5 s between the 5-6 keV band and 2-3 and 7-8 keV bands, with a broad lag profile resembling a relativistically-broadened iron line. The peak of the lag spectra shifts to lower energies at higher frequencies, consistent with the red wing of the line being emitted at smaller radii, as expected from reflection off the inner accretion disk. This is a first detection of a broad iron line using timing studies.Comment: final version, corrected small typo

1H0707-495 in 2011: An X-ray source within a gravitational radius of the event horizon

The Narrow Line Seyfert 1 Galaxy 1H0707-495 went in to a low state from 2010 December to 2011 February, discovered by a monitoring campaign using the X-Ray Telescope on the Swift satellite. We triggered a 100 ks XMM-Newton observation of the source in 2011 January, revealing the source to have dropped by a factor of ten in the soft band, below 1 keV, and a factor of 2 at 5 keV, compared with a long observation in 2008. The sharp spectral drop in the source usually seen around 7 keV now extends to lower energies, below 6 keV in our frame. The 2011 spectrum is well fit by a relativistically-blurred reflection spectrum similar to that which fits the 2008 data, except that the emission is now concentrated solely to the central part of the accretion disc. The irradiating source must lie within 1 gravitational radius of the event horizon of the black hole, which spins rapidly. Alternative models are briefly considered but none has any simple physical interpretation.Comment: 9 pages, 19 figures, MNRAS in pres

Evidence for High-Frequency QPOs with a 3:2 Frequency Ratio from a 5000 Solar Mass Black Hole

Following the discovery of 3:2 resonance quasi-periodic oscillations (QPOs) in M82X-1 (Pasham et al. 2014), we have constructed power density spectra (PDS) of all 15 (sufficiently long) {\it XMM-Newton} observations of the ultraluminous X-ray source NGC1313X-1 ($L_{X}$ $\approx$ 2$\times$10$^{40}$ erg/sec). We detect a strong QPO at a frequency of 0.29$\pm$0.01 Hz in data obtained on 2012 December 16. Subsequent searching of all the remaining observations for a 3:2/2:3 frequency pair revealed a feature at 0.46$\pm$0.02 Hz on 2003 Dec 13 (frequency ratio of 1.59$\pm$0.09). The global significance of the 0.29 Hz feature considering all frequencies between 0.1 and 4 Hz is $>$ 3.5 $\sigma$. The significance of the 0.46$\pm$0.02 Hz QPO is $>$ 3.5$\sigma$ for a search at 2/3 and 3/2 of 0.29 Hz. We also detect lower frequency QPOs (32.9$\pm$2.6 and 79.7$\pm$1.2 mHz). All the QPOs are super-imposed on a continuum consisting of flat-topped, band-limited noise, breaking into a power-law at a frequency of 16$\pm$3 mHz and white noise at $\gtrsim$ 0.1 Hz. NGC1313X-1's PDS is analogous to stellar-mass black holes' (StMBHs) PDS in the so-called steep power-law state, but with the respective frequencies (both QPOs and break frequencies) scaled down by a factor of $\sim$ 1000. Using the inverse mass-to-high-frequency QPO scaling of StMBHs, we estimate NGC1313X-1's black hole mass to be 5000$\pm$1300 $M_{\odot}$, consistent with an inference from the scaling of the break frequency. However, the implied Eddington ratio, L$_{Edd}$ $>$ 0.03$\pm$0.01, is significantly lower compared to StMBHs in the steep power-law state (L$_{Edd}$ $\gtrsim$ 0.2).Comment: Published in ApJ Letter

Synaptic Dysfunction in Neurodevelopmental Disorders Associated with Autism and Intellectual Disabilities

The discovery of the genetic causes of syndromic autism spectrum disorders and intellectual disabilities has greatly informed our understanding of the molecular pathways critical for normal synaptic function. The top-down approaches using human phenotypes and genetics helped identify causative genes and uncovered the broad spectrum of neuropsychiatric features that can result from various mutations in the same gene. Importantly, the human studies unveiled the exquisite sensitivity of cognitive function to precise levels of many diverse proteins. Bottom-up approaches applying molecular, biochemical, and neurophysiological studies to genetic models of these disorders revealed unsuspected pathogenic mechanisms and identified potential therapeutic targets. Moreover, studies in model organisms showed that symptoms of these devastating disorders can be reversed, which brings hope that affected individuals might benefit from interventions even after symptoms set in. Scientists predict that insights gained from studying these rare syndromic disorders will have an impact on the more common nonsyndromic autism and mild cognitive deficits

Long XMM observation of the Narrow-Line Seyfert 1 galaxy IRAS13224-3809: rapid variability, high spin and a soft lag

Results are presented from a 500ks long XMM-Newton observation of the Narrow-Line Seyfert 1 galaxy IRAS13224-3809. The source is rapidly variable on timescales down to a few 100s. The spectrum shows strong broad Fe-K and L emission features which are interpreted as arising from reflection from the inner parts of an accretion disc around a rapidly spinning black hole. Assuming a power-law emissivity for the reflected flux and that the innermost radius corresponds to the innermost stable circular orbit, the black hole spin is measured to be 0.988 with a statistical precision better than one per cent. Systematic uncertainties are discussed. A soft X-ray lag of 100s confirms this scenario. The bulk of the power-law continuum source is located at a radius of 2-3 gravitational radii.Comment: 7 pages, 14 figures, submitted to MNRA

Detection of a variable ultra-fast outflow in the Narrow Line Seyfert 1 galaxy PG 1448+273

Relativistically blueshifted absorption features of highly ionised ions, the so-called ultra-fast outflows (UFOs), have been detected in the X-ray spectra of a number of accreting supermassive black holes. If these features truly originate from accretion disc winds accelerated to more than 10 per cent of the speed of light, their energy budget is very significant and they can contribute to or even drive galaxy-scale feedback from active galactic nuclei (AGN). However, the UFO spectral features are often weak due to high ionisation of the outflowing material, and the inference of the wind physical properties can be complicated by other spectral features in AGN such as relativistic reflection. Here we study a highly accreting Narrow Line Seyfert 1 galaxy PG 1448+273. We apply an automated, systematic routine for detecting outflows in accreting systems and achieve an unambiguous detection of a UFO in this AGN. The UFO absorption is observed in both soft and hard X-ray bands with the XMM-Newton observatory. The velocity of the outflow is (26900 +- 600) km/s (~0.09c), with an ionisation parameter of log ({\xi} / erg cm s^-1)=4.03_{-0.08}^{+0.10} and a column density above 10^23 cm^-2. At the same time, we detect weak warm absorption features in the spectrum of the object. Our systematic outflow search suggests the presence of further multi-phase wind structure, but we cannot claim a significant detection considering the present data quality. The UFO is not detected in a second, shorter observation with XMM-Newton, indicating variability in time, observed also in other similar AGN.Comment: Accepted for publication in MNRAS. 14 pages, 11 figures, 1 tabl

Inclusive Pedagogies: the development and delivery of Australian Indigenous curricula in higher education

The construction of Indigenous knowledge within a western framework has been important in translating Indigenous issues and knowledge to mainstream Australia via educational systems. However, the production of Indigenous curricula is often essentialised and framed within binary locations, reliving traditional processes of assimilation and denying cultural identity and the diversity of student experience. This is because dominant educational frameworks intrude, through representation, reproduction and recontextualisation, Indigenous knowledge and identity. As a consequence, the development of genuine, alternative Indigenous curricula and pedagogy are inhibited. This paper explores the important role of inclusive curricula in supporting alternative processes of knowledge production and pluralistic approaches where the emphasis is on enhancement of active learning through collaboration and consultation. Inclusivity in the classroom recognises the diverse needs of learners, offers a range of teaching, learning and assessment approaches, and incorporates Indigenous knowledge systems through authentic learning experience that draws on Indigenous and non-Indigenous voices and knowledge frameworks. The paper also highlights the need to refigure constructions of difference and identity so as to provide meaningful mapping to support the development of content, assessment, methodology and delivery to integrate western and Indigenous frameworks within higher education curricula. This approach presents the opportunity to rethink pedagogic practices, to present diverse perspectives and contexts so as not to restrict or hinder the development of Indigenous curricula and pedagogy

Neurodegeneration: From cellular concepts to clinical applications

Developing therapies for neurodegenerative diseases will require new scientific approaches that take into account the detrimental effects of altered protein and RNA homeostasis on brain cells, the vulnerabilities of various organelles in certain diseases and aging neurons, and the complex multicellular interactions of the nervous system