Optical phase coherent timing of the Crab nebula pulsar with Iqueye at the ESO New Technology Telescope

The Crab nebula pulsar was observed in 2009 January and December with a novel very fast optical photon counter, Iqueye, mounted at the ESO 3.5 m New Technology Telescope. Thanks to the exquisite quality of the Iqueye data, we computed accurate phase coherent timing solutions for the two observing runs and over the entire year 2009. Our statistical uncertainty on the determination of the phase of the main pulse and the rotational period of the pulsar for short (a few days) time intervals are $\approx 1 \, \mu$s and ~0.5 ps, respectively. Comparison with the Jodrell Bank radio ephemerides shows that the optical pulse leads the radio one by ~240 $\mu$s in January and ~160 $\mu$s in December, in agreement with a number of other measurements performed after 1996. A third-order polynomial fit adequately describes the spin-down for the 2009 January plus December optical observations. The phase noise is consistent with being Gaussian distributed with a dispersion $\sigma$ of $\approx 15 \, \mu$s in most observations, in agreement with theoretical expectations for photon noise-induced phase variability.Comment: 10 pages, 5 figures. Accepted for publication in Monthly Notices of the Royal Astronomical Societ

Aqueye+: a new ultrafast single photon counter for optical high time resolution astrophysics

Aqueye+ is a new ultrafast optical single photon counter, based on single photon avalanche photodiodes (SPAD) and a 4-fold split-pupil concept. It is a completely revisited version of its predecessor, Aqueye, successfully mounted at the 182 cm Copernicus telescope in Asiago. Here we will present the new technological features implemented on Aqueye+, namely a state of the art timing system, a dedicated and optimized optical train, a high sensitivity and high frame rate field camera and remote control, which will give Aqueye plus much superior performances with respect to its predecessor, unparalleled by any other existing fast photometer. The instrument will host also an optical vorticity module to achieve high performance astronomical coronography and a real time acquisition of atmospheric seeing unit. The present paper describes the instrument and its first performances.Comment: Proceedings of the SPIE, Volume 9504, id. 95040C 14 pp. (2015

Aqueye optical observations of the Crab Nebula pulsar

We observed the Crab pulsar in October 2008 at the Copernico Telescope in Asiago - Cima Ekar with the optical photon counter Aqueye (the Asiago Quantum Eye) which has the best temporal resolution and accuracy ever achieved in the optical domain (hundreds of picoseconds). Our goal was to perform a detailed analysis of the optical period and phase drift of the main peak of the Crab pulsar and compare it with the Jodrell Bank ephemerides. We determined the position of the main peak using the steepest zero of the cross-correlation function between the pulsar signal and an accurate optical template. The pulsar rotational period and period derivative have been measured with great accuracy using observations covering only a 2 day time interval. The error on the period is 1.7 ps, limited only by the statistical uncertainty. Both the rotational frequency and its first derivative are in agreement with those from the Jodrell Bank radio ephemerides archive. We also found evidence of the optical peak leading the radio one by ~230 microseconds. The distribution of phase-residuals of the whole dataset is slightly wider than that of a synthetic signal generated as a sequence of pulses distributed in time with the probability proportional to the pulse shape, such as the average count rate and background level are those of the Crab pulsar observed with Aqueye. The counting statistics and quality of the data allowed us to determine the pulsar period and period derivative with great accuracy in 2 days only. The time of arrival of the optical peak of the Crab pulsar leads the radio one in agreement with what recently reported in the literature. The distribution of the phase residuals can be approximated with a Gaussian and is consistent with being completely caused by photon noise (for the best data sets).Comment: 7 pages, 7 figures. Accepted for publication in Astronomy and Astrophysic

Estimate of a spatially variable reservoir compressibility by assimilation of ground surface displacement data

Abstract. Fluid extraction from producing hydrocarbon reservoirs can cause anthropogenic land subsidence. In this work, a 3-D finite-element (FE) geomechanical model is used to predict the land surface displacements above a gas field where displacement observations are available. An ensemble-based data assimilation (DA) algorithm is implemented that incorporates these observations into the response of the FE geomechanical model, thus re- ducing the uncertainty on the geomechanical parameters of the sedimentary basin embedding the reservoir. The calibration focuses on the uniaxial vertical compressibility c M , which is often the geomechanical parameter to which the model response is most sensitive. The partition of the reservoir into blocks delimited by faults moti- vates the assumption of a heterogeneous spatial distribution of c M within the reservoir. A preliminary synthetic test case is here used to evaluate the effectiveness of the DA algorithm in reducing the parameter uncertainty associated with a heterogeneous c M distribution. A significant improvement in matching the observed data is obtained with respect to the case in which a homogeneous c M is hypothesized. These preliminary results are quite encouraging and call for the application of the procedure to real gas fields

A Low Noise and High Dynamic Charge Sensitive Amplifier-Shaper associated with Silicon Strip Detector for Compton Camera in hadrontherapy

submitted to conference record of IEEE NSS-MIC, Anaheim USA, 29 october-3 november 2012International audienceA 8 channel Front End Electronics (FEE) circuit has been designed and fabricated in 0.35 μm CMOS process from Austria Micro System to be coupled with the Silicon Strip Detector (SSD) of the Compton Camera for quality control of hadrontherapy. Each channel includes a Charge Sensitive Amplifier (CSA) followed by two parallel CR-RC shapers. Slow and fast shapers, with 1 μs and 15 ns shaping time, are used to measure the energy and to time stamp all events respectively. The two sides of the SSD are read thanks to a configurable system for holes and electrons. The CSA presents an open loop gain of 67 dB and 90 degrees phase margin assuring a high stability. The circuit has been successfully tested. The test results are in good agreement with analytic and simulation calculations. Here, we describe the principles and present measured performances of the prototype. A high linearity over the range of 3E3 to 3E6 electrons is reached with a conversion gain of 3.6 mV/fC. The circuit achieves an ENC (Equivalent Noise Charge) of 412 electrons rms. 75% of the total noise is generated by the small value of the feedback resistor chosen to avoid pile up phenomenon due to the 1E5 hits/s occupancy rate. A cross-talk of 2 % was measured, 99% of which is due to the power supply disturbances. The power supply dissipation is 21 mW/channel for 3.3 V supply voltage. The area of this design is 2871×1881 μm2 including pads

The regulation of cardiac intermediary metabolism by NADPH oxidases

NADPH oxidases (NOXs), enzymes whose primary function is to generate reactive oxygen species, are important regulators of the heart’s physiological function and response to pathological insults. The role of NOX-driven redox signalling in pathophysiological myocardial remodelling, including processes such as interstitial fibrosis, contractile dysfunction, cellular hypertrophy, and cell survival, is well recognized. While the NOX2 isoform promotes many detrimental effects, the NOX4 isoform has attracted considerable attention as a driver of adaptive stress responses both during pathology and under physiological states such as exercise. Recent studies have begun to define some of the NOX4-modulated mechanisms that may underlie these adaptive responses. In particular, novel functions of NOX4 in driving cellular metabolic changes have emerged. Alterations in cellular metabolism are a recognized hallmark of the heart’s response to physiological and pathological stresses. In this review, we highlight the emerging roles of NOX enzymes as important modulators of cellular intermediary metabolism in the heart, linking stress responses not only to myocardial energetics but also other functions. The novel interplay of NOX-modulated redox signalling pathways and intermediary metabolism in the heart is unravelling a new aspect of the fascinating biology of these enzymes which will inform a better understanding of how they drive adaptive responses. We also discuss the implications of these new findings for therapeutic approaches that target metabolism in cardiac disease

A Worked-out Example of Surrogate-based Bayesian Parameter and Field Identification Methods

none4sinoneFriedman, Noémi; Zoccarato, Claudia; Zander, Elmar; Matthies, Hermann G.Friedman, Noémi; Zoccarato, Claudia; Zander, Elmar; Matthies, Hermann G