Illness related uncertainty in the lives of people living with HIV

Section A This systematic literature review analysed twenty-three qualitative and quantitative studies investigating the experiences of illness uncertainty in the lives of people living with HIV. Specifically, the review aimed to identify sources of illness uncertainty for this population and the ways in which people living with HIV manage these uncertainties. These results were discussed within the frame of current theory and further areas of research were identified. Section B This is a cross-sectional online survey investigating the relationships between self-report measures of social environment (i.e. social support and experiences of discrimination), illness uncertainty and quality of life in an opportunity sample of people living with HIV. In line with theory, discrimination and social support were found to be differentially related to illness uncertainty. Furthermore, illness uncertainty was found to be related to quality of life. Clinical and theoretical implications as well as limitations to the study and future research were discussed

Still the century of ‘new’ environmental policy instruments? Exploring patterns of innovation and continuity

This article re-examines the political interest in and use of ‘new' environmental policy instruments (NEPIs) and other non-regulatory modes of governance. It starts by taking stock of the dynamic debate that has emerged around this topic since the turn of the century. It then contextualizes that debate by examining subsequent challenges to, and transformations in state-led governing and the widely acknowledged rise of 'new governance' more generally. It highlights the mismatch between: (a) the animated discussion of new instruments amongst policy makers and academics; and (b), the less active adoption and performance of them in practice. It makes an overall assessment of the role of instruments - both ‘old' and ‘new' - in the wider debate about governance, and suggests some steps that could be taken by both practitioners and scholars better to understand and possibly even utilise more NEPIs in the future

Role of a Conserved Glutamate Residue in the \u3cem\u3eEscherichia coli\u3c/em\u3e SecA ATPase Mechanism

Escherichia coli SecA uses ATP to drive the transport of proteins across cell membranes. Glutamate 210 in the “DEVD” Walker B motif of the SecA ATP-binding site has been proposed as the catalytic base for ATP hydrolysis (Hunt, J. F., Weinkauf, S., Henry, L., Fak, J. J., McNicholas, P., Oliver, D. B., and Deisenhofer, J. (2002) Science 297, 2018–2026). Consistent with this hypothesis, we find that mutation of glutamate 210 to aspartate results in a 90-fold reduction of the ATP hydrolysis rate compared with wild type SecA, 0.3 s–1versus 27 s–1, respectively. SecA-E210D also releases ADP at a slower rate compared with wild type SecA, suggesting that in addition to serving as the catalytic base, glutamate 210 might aid turnover as well. Our results contradict an earlier report that proposed aspartate 133 as the catalytic base (Sato, K., Mori, H., Yoshida, M., and Mizushima, S. (1996) J. Biol. Chem. 271, 17439–17444). Re-evaluation of the SecA-D133N mutant used in that study confirms its loss of ATPase and membrane translocation activities, but surprisingly, the analogous SecA-D133A mutant retains full activity, revealing that this residue does not play a key role in catalysis

Ketogenic diet-induced weight loss is associated with an increase in vitamin d levels in obese adults

Vitamin D is an important micronutrient involved in several processes. Evidence has shown a strong association between hypovitaminosis D and cardio-metabolic diseases, including obesity. A ketogenic diet has proven to be very effective for weight loss, especially in reducing fat mass while preserving fat-free mass. The aim of this study was to investigate the effect of a ketogenic diet-induced weight loss on vitamin D status in a population of obese adults. We enrolled 56 obese outpatients, prescribed with either traditional standard hypocaloric Mediterranean diet (SHMD) or very low-calorie ketogenic diet (VLCKD). Serum 25(OH)D concentrations were measured by chemiluminescence. The mean value of serum 25-hydroxyvitamin D (25(OH)D) concentrations in the whole population at baseline was 17.8 +/- 5.6 ng/mL, without differences between groups. After 12 months of dietetic treatment, in VLCKD patients serum 25(OH)D concentrations increased from 18.4 +/- 5.9 to 29.3 +/- 6.8 ng/mL (p < 0.0001), vs 17.5 +/- 6.1 to 21.3 +/- 7.6 ng/mL (p = 0.067) in the SHMD group (for each kilogram of weight loss, 25(OH)D concentration increased 0.39 and 0.13 ng/mL in the VLCKD and in the SHMD groups, respectively). In the VLCKD group, the increase in serum 25(OH)D concentrations was strongly associated with body mass index, waist circumference, and fatty mass variation. In a multiple regression analysis, fatty mass was the strongest independent predictor of serum 25(OH)D concentration, explaining 15.6%, 3.3%, and 9.4% of its variation in the whole population, in SHMD, and VLCKD groups, respectively. We also observed a greater reduction of inflammation (evaluated by high-sensitivity C reactive protein (hsCRP) values) and a greater improvement in glucose homeostasis, confirmed by a reduction of HOMA values, in the VLCKD versus the SHMD group. Taken together, all these data suggest that a dietetic regimen, which implies a great reduction of fat mass, can improve vitamin D status in the obese

Evaluasi Proses Perencanaan Strategis Dinas Sosial Kota Tangerang

Strategic planning is not only applied in business, but also already implemented in public organizations such Social Departement of Tangerang, a technical institute of local government where the fundamental duty is to implement the preparation and execution of regional policy. Difficulties in projecting the future to face the changes that occur are the reason of the importance of strategic planning to solve the problem through programs and activities. The planning process is implemented properly will produce the right and excellent programs in order to achieve organization goals, therefore the strategic planning process must be observed at every stage, started from preparation until establishment so the organization is well prepared to face changes in the future. The preparation starts from presentation of the data and the determination of the role by analyzing the environment, until the strategic issue is attained in order to determine the right programs and activities. This study aims to analyze the strategic planning process in Social Departement of Tangerang in order to be evaluated at each steps of the plan in order to achieve the organization goal by using planned program and activity. The programs have to be well planned in order to reach the goal of Social Department of Tangerang effectively and efficiently

Effects of age and eccentricity on visual target detection

The aim of this study was to examine the effects of aging and target eccentricity on a visual search task comprising 30 images of everyday life projected into a hemisphere, realizing a ±90° visual field. The task performed binocularly allowed participants to freely move their eyes to scan images for an appearing target or distractor stimulus (presented at 10°; 30°, and 50° eccentricity). The distractor stimulus required no response, while the target stimulus required acknowledgment by pressing the response button. One hundred and seventeen healthy subjects (mean age = 49.63 years, SD = 17.40 years, age range 20–78 years) were studied. The results show that target detection performance decreases with age as well as with increasing eccentricity, especially for older subjects. Reaction time also increases with age and eccentricity, but in contrast to target detection, there is no interaction between age and eccentricity. Eye movement analysis showed that younger subjects exhibited a passive search strategy while older subjects exhibited an active search strategy probably as a compensation for their reduced peripheral detection performance

BRSMG 780Frr: cultivar de soja transgênica.

A brsmg 780rr é sua nova opção em soja transgênica para o manejo da ferrugem asiática. Alta produtividade e resistência moderada à ferrugem asiática. Grupo de maturidade. Regiões edafoclimáticas de adaptação (REC 303 - MG Triângulo Mineiro e Alto Paranaíba). Reação a doenças. Características médias. População de plantas e ciclo em solos férteis. Manejo da ferrugem asiática.bitstream/item/57490/1/BRSMG780Frr.pdf1 folder