Geochemical Tracer in Coral as a Sea Surface Temperature Proxy: Records from Jukung Coral

Sr/Ca  has been analyzed from coral core from the Seribu Islands  reef complex  i.e  Jukung  Island.  SST  from  ERSST  dataset  and  air  temperature measured at Jakarta is used for Sr/Ca calibration. The results show that Jukung Island  coral  Sr/Ca  correlates  better  with  SST  than  with  air  temperature.  A comparison  between  the  Sr/Ca  records  with  the  Nino  3.4  index  shows  that Jukung  coral  sites  indicate  warming  sea  surface  temperatures  during  the beginning  of El Nino  events followed by cooling temperatures at the end of El Nino years

Geochemical Tracer in Coral as a Sea Surface Temperature Proxy: Records From Jukung Coral

Sr/Ca has been analyzed from coral core from the Seribu Islands reef complex i.e Jukung Island. SST from ERSST dataset and air temperature measured at Jakarta is used for Sr/Ca calibration. The results show that Jukung Island coral Sr/Ca correlates better with SST than with air temperature. A comparison between the Sr/Ca records with the Nino 3.4 index shows that Jukung coral sites indicate warming sea surface temperatures during the beginning of El Nino events followed by cooling temperatures at the end of El Nino years

Assessing the accuracy of δ<sup>18<\sup>O<sub>sw<?sub> estimates from corals: lessons from simple Monte Carlo simulations

EGU2008-A-04391 Paired measurements of δ18O and Sr/Ca in coral aragonite are routinely used for deriving estimates of δ18Osw and, by extension, sea surface salinity variations over the past centuries. However, in practice, the accuracy (or the error) of these estimates is often difficult to assess. Here, we use simulated proxy data and Monte-Carlo simulations to investigate the accuracy of δ18Osw estimates from paired coral δ18O and Sr/Ca measurements. First, we estimate expected values of coral Sr/Ca and δ18O from instrumental or reanalysis data of sea surface temperature (SST) and sea surface salinity (SSS). We then add the typical analytical errors onto the expected Sr/Ca (δ18O) data as random numbers and compute δ18Osw+error from the noisy proxy data for a 1000 sample Monte Carlo. From this simple Monte Carlo simulation, the range of correlation coefficients between δ18Osw+error and expected δ18Osw is estimated. As expected, we find that this range mainly depends on the magnitude of the actual SSS variations at a given site, as well as on the slope of the δ18Osw-SSS relationship. A comparison with real coral-based δ18Osw reconstructions from multiple sites indicates that correlations between reconstructed δ18Osw and instrumental SSS fall within the range of correlation coefficients predicted based on our Monte-Carlo simulation. Thus, our simple simulation exercise may help to assess the feasibility of δ18Osw and salinity reconstructions from corals in different climatic settings, provided that (i) some instrumental data of δ18Osw and/or SSS is available, and (ii) the slope of the δ18Osw-SSS relationship is known

Use of QSARs in international decision-making frameworks to predict health effects of chemical substances

This article is a review of the use of quantitative (and qualitative) structure-activity relationships (QSARs and SARs) by regulatory agencies and authorities to predict acute toxicity, mutagenicity, carcinogenicity, and other health effects. A number of SAR and QSAR applications, by regulatory agencies and authorities, are reviewed. These include the use of simple QSAR analyses, as well as the use of multivariate QSARs, and a number of different expert system approaches

Cholinergic modulation of response properties and orientation tuning of neurons in primary visual cortex of anaesthetized Marmoset monkeys

Cortical processing is strongly influenced by the actions of neuromodulators such as acetylcholine (ACh). Early studies in anaesthetized cats argued that acetylcholine can cause a sharpening of orientation tuning functions and an improvement of the signal-to-noise ratio (SNR) of neuronal responses in primary visual cortex (V1). Recent in vitro studies have demonstrated that acetylcholine reduces the efficacy of feedback and intracortical connections via the activation of muscarinic receptors, and increases the efficacy of feed-forward connections via the activation of nicotinic receptors. If orientation tuning is mediated or enhanced by intracortical connections, high levels of acetylcholine should diminish orientation tuning. Here we investigate the effects of acetylcholine on orientation tuning and neuronal responsiveness in anaesthetized marmoset monkeys. We found that acetylcholine caused a broadening of the orientation tuning in the majority of cells, while tuning functions became sharper in only a minority of cells. Moreover, acetylcholine generally facilitated neuronal responses, but neither improved signal-to-noise ratio, nor reduced trial-to-trial firing rate variance systematically. Acetylcholine did however, reduce variability of spike occurrences within spike trains. We discuss these findings in the context of dynamic control of feed-forward and lateral ⁄ feedback connectivity by acetylcholine