319 research outputs found
Influence of polymer excluded volume on the phase behavior of colloid-polymer mixtures
We determine the depletion-induced phase-behavior of hard sphere colloids and
interacting polymers by large-scale Monte Carlo simulations using very accurate
coarse-graining techniques. A comparison with standard Asakura-Oosawa model
theories and simulations shows that including excluded volume interactions
between polymers leads to qualitative differences in the phase diagrams. These
effects become increasingly important for larger relative polymer size. Our
simulations results agree quantitatively with recent experiments.Comment: 5 pages, 4 figures submitted to Physical Review Letter
First Measurement of Monoenergetic Muon Neutrino Charged Current Interactions
We report the first measurement of monoenergetic muon neutrino charged
current interactions. MiniBooNE has isolated 236 MeV muon neutrino events
originating from charged kaon decay at rest ()
at the NuMI beamline absorber. These signal -carbon events are
distinguished from primarily pion decay in flight and
backgrounds produced at the target station and decay pipe
using their arrival time and reconstructed muon energy. The significance of the
signal observation is at the 3.9 level. The muon kinetic energy,
neutrino-nucleus energy transfer (), and total cross
section for these events is extracted. This result is the first known-energy,
weak-interaction-only probe of the nucleus to yield a measurement of
using neutrinos, a quantity thus far only accessible through electron
scattering.Comment: 6 pages, 4 figure
Measurement of the antineutrino neutral-current elastic differential cross section
arXiv:1309.7257v1 [hep-ex
Apolipoprotein E4 has extensive conformational heterogeneity in lipid-free and lipid-bound forms
The ε4-allele variant of apolipoprotein E (ApoE4) is the strongest genetic risk factor for Alzheimer\u27s disease, although it only differs from its neutral counterpart ApoE3 by a single amino acid substitution. While ApoE4 influences the formation of plaques and neurofibrillary tangles, the structural determinants of pathogenicity remain undetermined due to limited structural information. Previous studies have led to conflicting models of the C-terminal region positioning with respect to the N-terminal domain across isoforms largely because the data are potentially confounded by the presence of heterogeneous oligomers. Here, we apply a combination of single-molecule spectroscopy and molecular dynamics simulations to construct an atomically detailed model of monomeric ApoE4 and probe the effect of lipid association. Importantly, our approach overcomes previous limitations by allowing us to work at picomolar concentrations where only the monomer is present. Our data reveal that ApoE4 is far more disordered and extended than previously thought and retains significant conformational heterogeneity after binding lipids. Comparing the proximity of the N- and C-terminal domains across the three major isoforms (ApoE4, ApoE3, and ApoE2) suggests that all maintain heterogeneous conformations in their monomeric form, with ApoE2 adopting a slightly more compact ensemble. Overall, these data provide a foundation for understanding how ApoE4 differs from nonpathogenic and protective variants of the protein
Measurement of the neutrino component of an anti-neutrino beam observed by a non-magnetized detector
Two independent methods are employed to measure the neutrino flux of the
anti-neutrino-mode beam observed by the MiniBooNE detector. The first method
compares data to simulated event rates in a high purity \numu induced
charged-current single \pip (CC1\pip) sample while the second exploits the
difference between the angular distributions of muons created in \numu and
\numub charged-current quasi-elastic (CCQE) interactions. The results from
both analyses indicate the prediction of the neutrino flux component of the
pre-dominately anti-neutrino beam is over-estimated - the CC1\pip analysis
indicates the predicted \numu flux should be scaled by , while
the CCQE angular fit yields . The energy spectrum of the flux
prediction is checked by repeating the analyses in bins of reconstructed
neutrino energy, and the results show that the spectral shape is well modeled.
These analyses are a demonstration of techniques for measuring the neutrino
contamination of anti-neutrino beams observed by future non-magnetized
detectors.Comment: 15 pages, 7 figures, published in Physical Review D, latest version
reflects changes from referee comment
A Search for Electron Antineutrino Appearance at the 1 Scale
The MiniBooNE Collaboration reports initial results from a search for
oscillations. A signal-blind analysis was
performed using a data sample corresponding to protons on
target. The data are consistent with background prediction across the full
range of neutrino energy reconstructed assuming quasielastic scattering, MeV: 144 electron-like events have been observed in this
energy range, compared to an expectation of events. No
significant excess of events has been observed, both at low energy, 200-475
MeV, and at high energy, 475-1250 MeV. The data are inconclusive with respect
to antineutrino oscillations suggested by data from the Liquid Scintillator
Neutrino Detector at Los Alamos National Laboratory.Comment: 5 pages, 3 figures, 2 table
Measurement of inclusive charged current interactions on carbon in a few-GeV neutrino beam
The SciBooNE Collaboration reports a measurement of inclusive charged current
interactions of muon neutrinos on carbon with an average energy of 0.8 GeV
using the Fermilab Booster Neutrino Beam. We compare our measurement with two
neutrino interaction simulations: NEUT and NUANCE. The charged current
interaction rates (product of flux and cross section) are extracted by fitting
the muon kinematics, with a precision of 6-15% for the energy dependent and 3%
for the energy integrated analyses. We also extract CC inclusive interaction
cross sections from the observed rates, with a precision of 10-30% for the
energy dependent and 8% for the energy integrated analyses. This is the first
measurement of the CC inclusive cross section on carbon around 1 GeV. These
results can be used to convert previous SciBooNE cross section ratio
measurements to absolute cross section values.Comment: 21 pages, 16 figures. Accepted by Phys. Rev. D. Minor revisions to
match the accepted versio
Search for Charged Current Coherent Pion Production on Carbon in a Few-GeV Neutrino Beam
The SciBooNE Collaboration has performed a search for charged current
coherent pion production from muon neutrinos scattering on carbon, \nu_\mu
^{12}C \to \mu^- ^{12}C \pi^+, with two distinct data samples. No evidence for
coherent pion production is observed. We set 90% confidence level upper limits
on the cross section ratio of charged current coherent pion production to the
total charged current cross section at 0.67\times 10^{-2} at mean neutrino
energy 1.1 GeV and 1.36\times 10^{-2} at mean neutrino energy 2.2 GeV.Comment: 18 pages, 16 figures, Minor revisions to match version accepted for
publication in Physical Review
Measurement of Muon Neutrino Quasi-Elastic Scattering on Carbon
The observation of neutrino oscillations is clear evidence for physics beyond
the standard model. To make precise measurements of this phenomenon, neutrino
oscillation experiments, including MiniBooNE, require an accurate description
of neutrino charged current quasi-elastic (CCQE) cross sections to predict
signal samples. Using a high-statistics sample of muon neutrino CCQE events,
MiniBooNE finds that a simple Fermi gas model, with appropriate adjustments,
accurately characterizes the CCQE events observed in a carbon-based detector.
The extracted parameters include an effective axial mass, M_A^eff = 1.23+/-0.20
GeV, that describes the four-momentum dependence of the axial-vector form
factor of the nucleon; and a Pauli-suppression parameter, kappa =
1.019+/-0.011. Such a modified Fermi gas model may also be used by future
accelerator-based experiments measuring neutrino oscillations on nuclear
targets.Comment: 5 pages, 3 figure
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