Cichorium intybus L. Extract Suppresses Experimental Gout by Inhibiting the NF-κB and NLRP3 Signaling Pathways

Background: The production and maturation of interleukin (IL)-1β, regulated by the NF-κB and NLRP3 signaling pathways, lie at the core of gout. This study aimed to evaluate the antigout effect of Cichorium intybus L. (also known as chicory) in vivo and in vitro. Methods: A gout animal model was established with monosodium urate (MSU) crystal injections. Rats were orally administered with chicory extract or colchicine. Levels of ankle edema, inflammatory activity, and IL-1β release were observed. Several essential targets of the NF-κB and NLRP3 signaling pathways were detected. Primary macrophages were isolated to verify the antigout mechanism of chicory extract as well as chicoric acid in vitro. Results: Improvements of swelling degree, inflammatory activity, and histopathological lesion in MSU-injected ankles were observed in the treatment with chicory extract. Further, the chicory extract significantly decreased IL-1β release by suppressing the NF-κB and NLRP3 signaling pathways in gout rats. Similar to the in vivo results, IL-1β release was also inhibited by chicory extract and chicoric acid, a specific effective compound in chicory, through the NF-κB and NLRP3 signaling pathways. Conclusion: This study suggests that chicory extract and chicoric acid may be used as promising therapeutic agents against gout by inhibiting the NF-κB and NLRP3 signaling pathways

Layered hydrated vanadium oxide as highly reversible intercalation cathode for aqueous Zn‐ion batteries

Abstract Aqueous Zn‐ion batteries (ZIBs) hold great potential in large‐scale energy storage systems due to the merits of low‐cost and high safety. However, the unstable structure of cathode materials and sluggish (de)intercalation kinetics of Zn2+ pose challenges for further development. Herein, highly reversible aqueous ZIBs are constructed with layered hydrated vanadium oxide as a cathode material. The electrochemical performances are further tested with the optimized electrolyte of 3M Zn(CF3SO3)2 and a cut‐off voltage of 0.4 to 1.3 V, exhibiting a remarkable capacity of 290 mAh g−1 at 0.5 A g−1, and long‐term cycling stability at high current density. Furthermore, the Zn2+ storage mechanism of V3O7⋅H2O is recognized as a highly reversible (de)intercalation process with good structural stability, implying the potential application in the field of large‐scale energy storage

Silicon Reduces Aluminum-Induced Suberization by Inhibiting the Uptake and Transport of Aluminum in Rice Roots and Consequently Promotes Root Growth

Silicon (Si) can alleviate aluminum (Al) toxicity in rice (Oryza sativa L.), but the mechanisms underlying this beneficial effect have not been elucidated, especially under long-term Al stress. Here, the effects of Al and Si on the suberization and development of rice roots were investigated. The results show that, as the Al exposure time increased, the roots accumulated more Al, and Al enhanced the deposition of suberin in roots, both of which ultimately inhibited root growth and nutrient absorption. However, Si restricted the apoplastic and symplastic pathways of Al in roots by inhibiting the uptake and transport of Al, thereby reducing the accumulation of Al in roots. Meanwhile, the Si-induced drop in Al concentration reduced the suberization of roots caused by Al through down-regulating the expression of genes related to suberin synthesis and then promoted the development of roots (such as longer and more adventitious roots and lateral roots). Moreover, Si also increased nutrient uptake by Al-stressed roots and thence promoted the growth of rice. Overall, these results indicate that Si reduced Al-induced suberization of roots by inhibiting the uptake and transport of Al in roots, thereby amending root growth and ultimately alleviating Al stress in rice. Our study further clarified the toxicity mechanism of Al in rice and the role of Si in reducing Al content and restoring root development under Al stress

Ultrasound-guided erector spinae plane block for perioperative analgesia in patients undergoing laparoscopic nephrectomy surgery: A randomized controlled trial

Study objective: Kidney neoplasms have a high incidence, and radical nephrectomy or partial nephrectomy are the main treatment options. Our study aims to investigate the use of ultrasound-guided erector spinae plane block for perioperative analgesia in patients undergoing laparoscopic nephrectomy surgery. Design: Prospective, randomized, double-blind. Setting: University hospital. Patients: Our study included 50 patients (ASA I-III) who underwent laparoscopic nephrectomy at the hospital of Second Affiliated Hospital of Army Medical University. Interventions: The patients were divided into two groups: the ESPB group and the control group. In the ESPB group, a mixture of 10 mL of 1% lidocaine, 10 mL of 0.7% ropivacaine, 0.5 μg/kg dexmedetomidine, and 5 mg of dexamethasone was administered. In the control group, 20 mL of 0.9% saline was administered. Measurements: The primary outcome measure was the total consumption of sufentanil during the intraoperative period. Secondary outcome measures included visual analogue scale (VAS) pain scores at rest and during coughing at 1 h, 6 h, 12 h, 24 h, and 48 h postoperatively, intraoperative consumption of remifentanil, frequency of rescue analgesic administration, consumption of rescue analgesia and incidence of postoperative nausea and vomiting within 48 h. Results: The ESPB group exhibited lower intraoperative consumption of sufentanil, lower consumption of rescue analgesia, as well as VAS scores at rest and during coughing within the first 24 h postoperatively, compared to the control group. However, no significant differences were observed in VAS scores at 48 h postoperatively, postoperative nausea and vomiting, or the need for postoperative rescue analgesia. Conclusions: Ultrasound-guided ESPB performed in patients who underwent laparoscopic nephrectomy demonstrated a substantial decrease in intraoperative opioid consumption, as well as lower VAS scores at rest and during coughing in the postoperative period

Improvement of the Geometric Accuracy for Microstructures by Projection Stereolithography Additive Manufacturing

Projection stereolithography creates 3D structures by projecting patterns onto the surface of a photosensitive material layer by layer. Benefiting from high efficiency and resolution, projection stereolithography 3D printing has been widely used to fabricate microstructures. To improve the geometric accuracy of projection stereolithography 3D printing for microstructures, a compensation method based on structure optimization is proposed according to mathematical analysis and simulation tests. The performance of the proposed compensation method is verified both by the simulation and the 3D printing experiments. The results indicate that the proposed compensation method is able to significantly improve the shape accuracy and reduce the error of the feature size. The proposed compensation method is also proved to improve the dimension accuracy by 21.7%, 16.5% and 19.6% for the circular, square and triangular bosses respectively. While the improvements on the dimension accuracy by 16%, 17.6% and 13.8% for the circular, square and triangular holes are achieved with the proposed compensation method. This work is expected to provide a method to improve the geometric accuracy for 3D printing microstructures by projection stereolithography

Improvement of the Geometric Accuracy for Microstructures by Projection Stereolithography Additive Manufacturing

Projection stereolithography creates 3D structures by projecting patterns onto the surface of a photosensitive material layer by layer. Benefiting from high efficiency and resolution, projection stereolithography 3D printing has been widely used to fabricate microstructures. To improve the geometric accuracy of projection stereolithography 3D printing for microstructures, a compensation method based on structure optimization is proposed according to mathematical analysis and simulation tests. The performance of the proposed compensation method is verified both by the simulation and the 3D printing experiments. The results indicate that the proposed compensation method is able to significantly improve the shape accuracy and reduce the error of the feature size. The proposed compensation method is also proved to improve the dimension accuracy by 21.7%, 16.5% and 19.6% for the circular, square and triangular bosses respectively. While the improvements on the dimension accuracy by 16%, 17.6% and 13.8% for the circular, square and triangular holes are achieved with the proposed compensation method. This work is expected to provide a method to improve the geometric accuracy for 3D printing microstructures by projection stereolithography

Simultaneously enhancing moisture and mechanical stability of flexible perovskite solar cells via a polyimide interfacial layer

Perovskite solar cells (PSCs) have aroused tremendous attention due to the high power conversion efficiency (PCE) and flexibility of the organic-inorganic hybrid perovskite films. However, the commercialization of perovskite solar cells is still impeded due to the instability issue induced by moisture and mechanical stress. Herein, we introduce soluble hydrophobic polyimide (PI) as an interfacial layer on top of the perovskite film to block the infiltration of moisture into the perovskite film. The MAPbI3-based solar cell with the insertion of PI layer exhibited an impressive stability, maintaining 87% of the initial PCE even after exposing to 50% relative humidity for 550 h and presenting a decent PCE of 21.22% due to its ability to extract holes and reduce trap-assisted recombination. Moreover, the high tolerance of PI to the mechanical stress gives a more stable flexibility to the PSCs under constant bending