Task Demands Modulate the Effects of Speech on Text Processing

Task-irrelevant background sound can disrupt performance of visually-based cognitive tasks. The cross-modal breakdown of attentional selectivity in the context of reading was addressed using analyses of eye-movements. Moreover, the study addressed whether task-sensitivity to distraction via background speech on reading was modulated by the cognitive demands of the focal task. Two randomly-assigned groups of native-Chinese participants read the same set of Chinese experimental sentences while being exposed to meaningful speech, meaningless (foreign) speech, or silence. For one group, participants were instructed to judge whether the sentences made sense (i.e., semantic acceptability task); for another, participants were instructed to detect whether the sentences contained a non-character (i.e., non-character detection task). Results showed no significant effect across sound conditions for the non-character detection task. For the semantic acceptability task, however, there was a substantial disruptive effect of the meaningfulness of the speech. Compared with reading with meaningless speech or reading in silence, the meaningful speech increased numbers of fixations, regressions, regression path and total reading times. These results suggest that the disruption of reading by background speech is jointly dependent on the nature of the speech and the task-process deployed, thereby favouring an Interference-by-Process account over Interference-by-Content and Attentional Diversion accounts of distraction to reading by background sound

Population structure of Coilia nasus in the Yangtze River revealed by insertion of short interspersed elements

AbstractCoilia nasus is found in the Yangtze River and the coastal waters of China, Korea, and Japan. Two ecotypes (anadromous and freshwater-resident populations) are distributed throughout the Yangtze River basin based on their ecology and behavior, but relatively little is known about the population structure of this species. Analysis of short interspersed element (SINE) insertions, which vary among individuals, has been acknowledged to provide a unique way to study population divergence. SINEs isolated from C. nasus were characterized, and this enabled analysis of the SINE insertion pattern in six populations distributed throughout the Yangtze River basin. In all populations, four SINE loci displayed individual polymorphism, and two SINE loci showed a stochastic loss in all individuals of two resident populations. The correlation between genetic and geographic populations indicated a degree of genetic isolation in this species. In contrast with Coilia grayii and Coilia mystus, two SINE loci appeared only in C. nasus. Sequencing analysis indicated that the high insertion variability of SINEs was attributed mainly to the tails, which contained various repeat copies. The results in this study will be useful for sustainable management of fishery resources and conservation of this species

Ranking the invasions of cheaters in structured populations

The identification of the most influential individuals in structured populations is an important research question, with many applications across the social and natural sciences. Here, we study this problem in evolutionary populations on static networks, where invading cheaters can lead to the collapse of cooperation. We propose six strategies to rank the invading cheaters and identify those which mostly facilitate the collapse of cooperation. We demonstrate that the type of successful rankings depend on the selection strength, the underlying game, and the network structure. We show that random ranking has generally little ability to successfully identify invading cheaters, especially for the stag-hunt game in scale-free networks and when the selection strength is strong. The ranking based on degree can successfully identify the most influential invaders when the selection strength is weak, while more structured rankings perform better at strong selection. Scale-free networks and strong selection are generally detrimental to the performance of the random ranking, but they are beneficial for the performance of structured rankings. Our research reveals how to identify the most influential invaders using statistical measures in structured communities, and it demonstrates how their success depends on population structure, selection strength, and on the underlying game dynamics

Effects of irrelevant speech on semantic and phonological judgments of Chinese characters

This study employed two decision tasks to investigate whether background speech impairs lexical processing and whether particular characteristics of the background speech differentially contribute to any such impairment. The same set of Chinese character pairs was displayed to two randomly-assigned groups of native-reader Chinese participants with an auditory background of normal Chinese speech, phonotactically-legal meaningless speech, spectrally-rotated speech (i.e., a meaningless sound with no accessible phonological form) or silence. In one task, participants were instructed to decide whether the presented character pair shared the same meaning, and in the other task, whether they shared the same initial phoneme (semantic and phonological judgment task respectively). Participants in the semantic judgment task attained higher accuracy rates and shorter reaction times than those in the phonological judgment task. Phonological properties of meaningless speech produced an increase in participants' reaction times in the phonological judgment task but not the semantic task, whilst the semantic properties of speech produced an increase in participants' reaction times exclusively in the semantic judgment task. The results indicate that background speech is disruptive to lexical processing. Furthermore, primary task demands associated with lexical processing modulate the extent to which participants experience phonological and semantic disruption due to background speech

Reading skill modulates the effect of parafoveal distractors on foveal lexical decision in deaf students

In low-level perceptual tasks and reading tasks, deaf individuals show a redistribution of spatial visual attention toward the parafoveal and peripheral visual fields. In the present study, the experiment adopted the modified flanker paradigm and utilized a lexical decision task to investigate how these unique visual skills may influence foveal lexical access in deaf individuals. It was predicted that irrelevant linguistic stimuli presented in parafoveal vision, during a lexical decision task, would produce a larger interference effect for deaf college student readers if the stimuli acted as distractors during the task. The results showed there was a larger interference effect in deaf college student readers compared to the interference effect observed in participants with typical levels of hearing. Furthermore, deaf college student readers with low-skilled reading levels showed a larger interference effect than those with high-skilled reading levels. The current study demonstrates that the redistribution of spatial visual attention toward the parafoveal visual regions in deaf students impacts foveal lexical processing, and this effect is modulated by reading skill. The findings are discussed in relation to the potential effect that enhanced parafoveal attention may have on everyday reading for deaf individuals

The association between diabetes status and latent-TB IGRA levels from a cross-sectional study in eastern China

BackgroundThere is a debate regarding the sensitivity of the QuantiFERON-TB Gold In-Tube (QFT) among people with diabetes, and prior studies have shown heterogeneous results. We evaluated whether the QFT TB antigen was modified among persons with differing diabetes status and other related risk factors.MethodsA cross-sectional study of 5,302 people was conducted to screen latent tuberculosis infection (LTBI) in eastern China. The QFT assay was performed as an indicator of LTBI. Fasting plasma glucose (FPG) was collected from each participant; the definition of diabetes followed the guidelines from the American Diabetes Association. Participants were classified into normoglycemia, prediabetes, undiagnosed diabetes, and previously diagnosed diabetes to evaluate the relationship between the QFT TB antigen and distinct diabetes status.ResultsTB antigen values from the QFT were statistically different among participants with differing diabetes status (P = 0.008). Persons with undiagnosed diabetes had a higher TB antigen value (0.96 ± 0.20) than persons with normoglycemia (0.50 ± 0.02, P < 0.05). However, the TB antigen values demonstrated no significant difference among the four different diabetic groups when stratified by the standard cutoff for the QFT (P = 0.492 for the positive group and P = 0.368 for the negative group). In a linear regression model, we found that FPG, age, and smoking were positively associated with the QFT TB antigen value (P = 0.017, P < 0.001, and P < 0.001).ConclusionsDiabetes status had little influence on the level of QFT TB antigen response among IGRA-positive persons. However, FPG, old age, and smoking were important risk factors for increasing levels of QFT TB antigen

Efficacy of intra-arterial chemotherapy with sequential anti-PD-1 antibody in unresectable gastric cancer: A retrospective real-world study

BackgroundThe prognosis of unresectable gastric cancer is poor, while the efficacy of anti-PD antibodies has not been evaluated.MethodsPatients with unresectable gastric cancer who received intra-arterial chemotherapy (IAC) with sequential anti-PD-1 antibody as induction therapy in Jinling Hospital were retrospectively analyzed. The primary outcome is R0 resection rate. The secondary outcomes include safety, conversion surgery rate, overall survival (OS) and progression free survival (PFS) after postoperative IAC and anti-PD-1 treatments. Meanwhile, Tumor immunity in the microenvironment (TIME) before and after IAC was comprehensively dissected with multiplex immunofluorescence in order to detect possible mechanisms favoring anti-PD-1 treatment response.ResultsBetween May 2019 and October 2020, 36 patients received at least one cycle of IAC with sequential anti-PD-1 antibody in our institution. The objective response was achieved in 28 patients (77.8%). Thirty patients (83.3%) successfully underwent conversion surgery, among which R0 resection was managed in 25/30 patients, and 23.3% (7/30) was assessed as pathological complete remission. During the median follow-up period of 19.7 months, patients who underwent R0 resection displayed superior OS (HR 0.14 [95% CI 0.04-0.50], P < 0.0001) and PFS (HR 0.11 [0.03-0.44], P < 0.0001) than those who did not. Grade 3 adverse events (AEs) were only encountered in 19.4% patients, no grade 4 AEs observed. In TIME analysis, the number of tertiary lymphoid structures (TLSs) (P = 0.004) were greatly induced by IAC, as well as CD8+ T cells (P = 0.011) and PD-1+ cells (P = 0.025). Meanwhile, Tumor associated macrophages shifted towards anti-tumor M1-like subtypes, with CD68+CD163+ M2-like subpopulation significantly decreased (P = 0.04).ConclusionPreoperative IAC with sequential anti-PD-1 antibody exhibited promising clinical benefit for unresectable gastric cancer with remarkable conversion rate and R0 resection rate, and also prolonged survival as postoperative regimen. TIME transformation induced by ICA might mediate the additive effect with the immune checkpoint inhibitor

PCR and Magnetic Bead-Mediated Target Capture for the Isolation of Short Interspersed Nucleotide Elements in Fishes

Short interspersed nucleotide elements (SINEs), a type of retrotransposon, are widely distributed in various genomes with multiple copies arranged in different orientations, and cause changes to genes and genomes during evolutionary history. This can provide the basis for determining genome diversity, genetic variation and molecular phylogeny, etc. SINE DNA is transcribed into RNA by polymerase III from an internal promoter, which is composed of two conserved boxes, box A and box B. Here we present an approach to isolate novel SINEs based on these promoter elements. Box A of a SINE is obtained via PCR with only one primer identical to box B (B-PCR). Box B and its downstream sequence are acquired by PCR with one primer corresponding to box A (A-PCR). The SINE clone produced by A-PCR is selected as a template to label a probe with biotin. The full-length SINEs are isolated from the genomic pool through complex capture using the biotinylated probe bound to magnetic particles. Using this approach, a novel SINE family, Cn-SINE, from the genomes of Coilia nasus, was isolated. The members are 180–360 bp long. Sequence homology suggests that Cn-SINEs evolved from a leucine tRNA gene. This is the first report of a tRNALeu-related SINE obtained without the use of a genomic library or inverse PCR. These results provide new insights into the origin of SINEs