Lepton Mixing Parameters from Δ(48)\Delta(48) Family Symmetry and Generalised CP

We provide a systematic and thorough exploration of the $\Delta(48)$ family symmetry and the consistent generalised CP symmetry. A model-independent analysis of the achievable lepton flavor mixing is performed by considering all the possible remnant symmetries in the neutrino and the charged lepton sectors. We find a new interesting mixing pattern in which both lepton mixing angles and CP phases are nontrivial functions of a single parameter $\theta$. The value of $\theta$ can be fixed by the measured reactor mixing angle $\theta_{13}$, and the excellent agreement with the present data can be achieved. A supersymmetric model based on $\Delta(48)$ family symmetry and generalised CP symmetry is constructed, and this new mixing pattern is exactly reproduced.Comment: 48 pages, 7 figure

The H(sub infinity) optimal controller design and reduction for the inertial hold mode of the attitude control system of the XTE spacecraft

The Inertial Hold Mode (IHM) is one mode of the attitude control system of the X-ray Timing Explorer spacecraft that is disturbed by both parametric uncertainties and external torque disturbance. The IHM model is modified into a typical H-infinity mixed-sensitivity problem through choosing suitable weighting functions W(sub 1)(s) and W(sub 3)(s). The controller is designed by the H-infinity optimization technique with the transformation of shifting the imaginary axis. It can stabilize the plant with uncertainties from the natural frequencies of the flexible body. The gain margin and phase margin of the system are 24.03 db and 55.04 deg, respectively. The step response attenuates to zero within 150 seconds. These show that the controller satisfies the specified requirements. Since the order of the controller appears high, it is reduced to fourth order one. The results show that the stability and the performance of the system with the reduced controller are retained perfectly

A revision of the genus Eurymesosa Breuning, 1938 (Cerambycidae, Lamiinae, Mesosini)

A taxonomic revision and redescription of the genus Eurymesosa Breuning, 1938 are presented, including a key to species. Three of the five currently accepted species are considered valid: Eurymesosa ventralis (Pascoe, 1865), Eurymesosa allapsa (Pascoe, 1866) and Eurymesosa ziranzhiyi Yamasako & Lin, 2016. Three junior synonyms are proposed for E. ventralis: Eurymesosa albostictica Breuning, 1962, syn. nov., Eurymesosa affinis Breuning, 1970, syn. nov., and Eurymesosa multinigromaculata Breuning, 1974, syn. nov. Additionally, E. allapsa (Pascoe, 1866) is resurrected from synonyms of E. ventralis. Females of E. allapsa and E. ziranzhiyi Yamasako & Lin, 2016 are described for the first time

N′-(2-Bromo-5-hy­droxy-4-meth­oxy­benzyl­idene)-3,5-dihy­droxy­benzo­hydrazide methanol monosolvate

In the crystal structure of the title compound, C15H13BrN2O5·CH3OH, the methanol solvent mol­ecule links symmetry-related mol­ecules through O—H⋯O and N—H⋯O hydrogen bonds. Further inter­molecular O—H⋯O hydrogen bonds link symmetry-related mol­ecules, leading to the formation of a three-dimensional network. Two of the H atoms involved in hydrogen bonding are disordered. The dihedral angle between the rings is 5.64 (14)°

Liraglutide-induced reduction of myocardial ischemiareperfusion injury in rats via ERK1/2 signaling pathway

Purpose: To investigate the protective effect of liraglutide on myocardial ischemia reperfusion (I/R) injury and its molecular mechanism.Methods: Ischemia reperfusion model male Sprague-Dawley (SD) rats were randomly divided into negative control group, I/R group (saline), liraglutide group (liraglutide) and PD group (liraglutide + PD98059). The weight of myocardium in ischemic and infarction areas of the heart, myocardial injury biomarker, oxidative stress, as well as expressions of mRNA molecules of apoptosis were determined.Results: The myocardial mass of ischemic and infarcted areas of the heart (relative to left ventricular mass) of I/R group were significantly higher (p ˂ 0.05) than those of negative control group, but significantly lower in liraglutide group than in I/R group (p > 0.05). However, the parameters were significantly higher in PD group than in liraglutide group (p ˂ 0.05). CK, CK-MB and LDH activities, as well as levels of cTnI and cTnT in I/R group were significantly higher (p ˂ 0.05) than those of negative control group. However, the parameters were significantly lower (p ˂ 0.05) in liraglutide group than in I/R group, but higher in PD group (p ˂ 0.05) than in liraglutide group. Serum SOD, GSH-Px, CAT activities and tBcl-2 mRNA expression were significantly lower in I/R group than those of negative control group (p ˂ 0.001), while those PD group were significantly lower than those of liraglutide group (p ˂ 0.001).Conclusion: Liraglutide alleviates myocardial ischemia-reperfusion injury and inhibits oxidative stress and apoptosis via ERK1/2 signaling pathway in rats, but further studies are required to ascertain the clinical efficacy and safety of the compound.Keywords: Ischemia-reperfusion injury, Liraglutide, ERK1/2 signal pathway, Oxidative stress, Apoptosi

A Peptide That Binds Specifically to the β-Amyloid of Alzheimer's Disease: Selection and Assessment of Anti-β-Amyloid Neurotoxic Effects

The accumulation of the amyloid-β peptide (Aβ) into amyloid plaques, an essential event in Alzheimer's disease (AD) pathogenesis, has caused researchers to seek compounds that physiologically bind Aβ and modulate its aggregation and neurotoxicity. In order to develop new Aβ-specific peptides for AD, a randomized 12-mer peptide library with Aβ1-10 as the target was used to identify peptides in the present study. After three rounds of selection, specific phages were screened, and their binding affinities to Aβ1-10 were found to be highly specific. Finally, a special peptide was synthesized according to the sequences of the selected phages. In addition, the effects of the special peptide on Aβ aggregation and Aβ-mediated neurotoxicity in vitro and in vivo were assessed. The results show that the special peptide not only inhibited the aggregation of Aβ into plaques, but it also alleviated Aβ-induced PC12 cell viability and apoptosis at appropriate concentrations as assessed by the cell counting kit-8 assay and propidium iodide staining. Moreover, the special peptide exhibited a protective effect against Aβ-induced learning and memory deficits in rats, as determined by the Morris water maze task. In conclusion, we selected a peptide that specifically binds Aβ1-10 and can modulate Aβ aggregation and Aβ-induced neuronal damage. This opens up possibilities for the development of a novel therapeutic approach for the treatment of AD

2-Fluoro-N′-(2-hy­droxy­benzyl­idene)benzohydrazide

In the title compound, C14H11FN2O2, an intra­molecular O—H⋯N hydrogen bond influences the mol­ecular conformation; the two benzene rings form a dihedral angle of 18.4 (3)°. The F atom is disordered over two positions in a 0.717 (5):0.283 (5) ratio. In the crystal, inter­molecular N—H⋯O hydrogen bonds link the mol­ecules into chains extending along the c axis