End of the World Brane meets TTˉT\bar{T}

End of the world branes in AdS have been recently used to study problems deeply connected to quantum gravity, such as black hole evaporation and holographic cosmology. With non-critical tension and Neumann boundary condition, the end of the world brane often represents part of the degrees of freedom in AdS gravity and geometrically it is only part of the entire boundary. On the other hand, holographic $T\bar{T}$ deformation can also give a boundary as a cutoff surface for AdS gravity. In this paper we consider AdS gravity with both the end of the world boundary and the cutoff boundary. Using partial reduction we obtain a brane world gravity glued to a $T\bar{T}$ deformed bath. We compute both entanglement entropy and Page curve, and find agreement between the holographic results and island formula results.Comment: 1+26 pages, 11 figure

Factors influencing self-healing mechanisms of cementitious materials: A review

The increasing awareness of climate change and global warming has pushed industries to be more conscious of their environmental impact, especially in the construction industry with the main contributor being concrete. Concrete is a material that is in very high demand in the construction industry for structural applications. However, it’s a material with a major concern with the challenges of microcracking. New technology has seen the development of self-healing material, using novel techniques to bring cementitious materials back to its original state. This paper reviews and evaluates the novel techniques adopted by the researchers in the field to achieve a self-healing material, with the main focus being on the factors influencing the mechanisms of autogenous healing and bacteria-based healing. Various parameters including bacteria type, pH, temperature, nutrient, urea, and Ca2+ concentration, bacteria concentration and application, pre-cracking, healing condition, cement type, and crack width are all important for healing efficiency, although the use of water to facilitate both autogenous and ureolytic bacteria healing mechanism is paramount for the triggering of healing processes. This study thoroughly presents various factors and their correlation to the healing mechanisms of autogenous healing and ureolytic bacteria healing. Further studies are identified to better understand the exact mechanism taking place and which healing process contributed to how much of the healing, and this review could serve as an informative platform for these pursues

Critical review on the thermal conductivity modelling of silica aerogel composites

As a new generation of thermal insulation materials, the effective thermal conductivity of aerogel and its composites is extremely low. The nanoporous structure of aerogels demobilises the movement of gas molecules, and the nano-skeleton system restricts solid heat transfer because of the size effect. Numerous research and modelling works have been carried out to understand and predict heat transfers. This review thoroughly discusses the existing theories and models of silica aerogel composites in gas, solid and radiative heat transfers. It investigates the correlation of the pore size distribution and solid skeleton network of the composites with the thermal conductivity. The review then assesses the advances of the development and questions remaining for further development, including 1) some unexplainable performance of existing models and 2) improvements required for gas and solid thermal conductivity models. Bridging the identified research gaps shall lead researchers to understand existing models better, develop a more accurate model based on more realistic microstructure simulation and further innovate the models for other emerging composites

Construction of EMT related prognostic signature for kidney renal clear cell carcinoma, through integrating bulk and single-cell gene expression profiles

Introduction: Kidney renal clear cell carcinoma (KIRC), as a main type of malignant kidney cancers, has a poor prognosis. Epithelial-mesenchymal transformation (EMT) exerts indispensable role in tumor progression and metastasis, including in KIRC. This study aimed to mine more EMT related details and build prognostic signature for KIRC.Methods: The KIRC scRNA-seq data and bulk data were downloaded from GEO and TCGA databases, respectively. The cell composition in KIRC was calculated using CIBERSORT. Univariate Cox regression analysis and LASSO Cox regression analysis were combined to determine the prognostic genes. Gene set variation analysis and cell-cell communication analysis were conducted to obtain more functional information. Additionally, functional analyses were conducted to determine the biological roles of si-LGALS1 in vitro.Results: We totally identified 2,249 significant differentially expressed genes (DEGs) in KIRC samples, meanwhile a significant distinct expression pattern was found in KIRC, involving Epithelial Mesenchymal Transition pathway. Among all cell types, significantly higher proportion of epithelial cells were observed in KIRC, and 289 DEGs were identified in epithelial cells. After cross analysis of all DEGs and 970 EMT related genes, SPARC, TMSB10, LGALS1, and VEGFA were optimal to build prognostic model. Our EMT related showed good predictive performance in KIRC. Remarkably, si-LGALS1 could inhibit migration and invasion ability of KIRC cells, which might be involved in suppressing EMT process.Conclusion: A novel powerful EMT related prognostic signature was built for KIRC patients, based on SPARC, TMSB10, LGALS1, and VEGFA. Of which, si-LGALS1 could inhibit migration and invasion ability of KIRC cells, which might be involved in suppressing EMT process

2023 roadmap for potassium-ion batteries

The heavy reliance of lithium-ion batteries (LIBs) has caused rising concerns on the sustainability of lithium and transition metal and the ethic issue around mining practice. Developing alternative energy storage technologies beyond lithium has become a prominent slice of global energy research portfolio. The alternative technologies play a vital role in shaping the future landscape of energy storage, from electrified mobility to the efficient utilization of renewable energies and further to large-scale stationary energy storage. Potassium-ion batteries (PIBs) are a promising alternative given its chemical and economic benefits, making a strong competitor to LIBs and sodium-ion batteries for different applications. However, many are unknown regarding potassium storage processes in materials and how it differs from lithium and sodium and understanding of solid–liquid interfacial chemistry is massively insufficient in PIBs. Therefore, there remain outstanding issues to advance the commercial prospects of the PIB technology. This Roadmap highlights the up-to-date scientific and technological advances and the insights into solving challenging issues to accelerate the development of PIBs. We hope this Roadmap aids the wider PIB research community and provides a cross-referencing to other beyond lithium energy storage technologies in the fast-pacing research landscape

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

Analysis of the Mechanical Properties and Damage Mechanism of Carbon Fiber/Epoxy Composites under UV Aging

The UV durability of carbon fiber composites has been a concern. In this work, UV irradiation on carbon fiber-reinforced polymer (CFRP) materials was performed using an artificial accelerated UV aging chamber to investigate the effect of UV exposure on carbon fiber composites. UV aging caused some of the macromolecular chains on the surface resin to break, resulting in the loss of small molecules and loss of mass. After 80 days of UV irradiation exposure, a significant decline in the macroscopic mechanical properties occurred in the longitudinal direction, with the largest decrease of 23% in longitudinal compressive strength and a decreasing trend in the transverse mechanical properties at the later stage of aging. The microscopic mechanical properties of the CFRP specimens were characterized using nanoindentation, and it was found that UV aging had an embrittlement effect on the matrix, and its hardness/modulus values were higher than the initial values with UV exposure. The fibers were less affected by UV irradiation

Fracture Performance Study of Carbon-Fiber-Reinforced Resin Matrix Composite Winding Layers under UV Aging Effect

There is limited research on the fracture toughness of carbon-fiber-reinforced polymer (CFRP) materials under accelerated UV aging conditions. In this study, the primary focus was on investigating the influence of varying durations of ultraviolet (UV) irradiation at different temperatures on the Mode I, Mode II, and mixed-mode fracture toughness of CFRP laminates. The results indicate that with increasing UV aging duration, the material’s Mode I fracture toughness increases, while Mode II fracture toughness significantly decreases. The mixed-mode fracture toughness exhibits an initial increase followed by a subsequent decrease. Furthermore, as the aging temperature increases, the change in the fracture toughness of the material is more obvious and the rate of change is faster. In addition, the crack expansion of the composite layer of crack-containing Type IV hydrogen storage cylinders was analyzed based on the extended finite element method in conjunction with the performance data after UV aging. The results reveal that cracks in the aged composite material winding layers become more sensitive, with lower initiation loads and longer crack propagation lengths under the same load. UV aging diminishes the overall load-bearing capacity and crack resistance of the hydrogen storage cylinder, posing increased safety risks during its operational service