Overview of Wind Parameters Sensing Methods and Framework of a Novel MCSPV Recombination Sensing Method for Wind Turbines

The paper presents an overview of the traditional methods to obtain wind parameters such as wind speed, wind direction and air density. After analyzing wind turbines’ arrangements and communication characteristics and the correlation of operation data between wind turbines, the paper proposes a novel recombination-sensing method route of “measuring–correlating–sharing–predicting–verifying” (MCSPV) and explores its feasibility. The analysis undertaken in the paper shows that the wind speed and wind direction instrument fixed on the wind turbine nacelle is simple and economical. However, it performs in-process measurement, which restricts the control optimization of wind turbines. The light detection and ranging (LIDAR) technology which is accurate and fast, ensures an early and super short-time sensing of wind speed and wind direction but it is costly. The wind parameter predictive perception method can predict wind speed and wind power at multiple time scales statistically, but it has limited significance for the control of the action of wind turbines. None of the traditional wind parameter-sensing methods have ever succeeded in air density sensing. The MCSPV recombination sensing method is feasible, both theoretically and in engineering, for realizing the efficient and accurate sensing and obtaining of such parameters as wind speed, wind direction and air density aimed at the control of wind turbines

Comparison of Neutralizing Antibody Response Kinetics in Patients with Hand, Foot, and Mouth Disease Caused by Coxsackievirus A16 or Enterovirus A71: A Longitudinal Cohort Study of Chinese Children, 2017-2019

10.4049/jimmunol.2200143JOURNAL OF IMMUNOLOGY2092280-28

Diagnostic performance of different specimens in detecting enterovirus A71 in children with hand, foot and mouth disease.

Hand, foot and mouth disease (HFMD) is a major public health problem among children in the Asia-Pacific region. The optimal specimen for HFMD virological diagnosis remains unclear. Enterovirus A71 (EV-A71) neutralizing antibody titres detected in paired sera were considered the reference standard for calculating the sensitivity, specificity, positive and negative predictive value of throat swabs, rectal swabs, stool, blood samples and cerebrospinal fluid (CSF) by RT-PCR or ELISA assay. In this study, clinical samples from 276 HFMD patients were collected for analysing the sensitivity of different kind of specimens. Our results showed that stool had the highest sensitivity (88%, 95% CI: 74%-96%) and agreement with the reference standard (91%). The order of diagnostic yield for EV-A71 infection was stool sample ​≥ ​rectal swab ​> ​throat swab ​> ​blood sample ​> ​CSF sample, and using a combination of clinical samples improved sensitivity for enterovirus detection. The sensitivity of ELISA for IgM antibody detection in sterile-site specimens was significantly higher than that of RT-PCR (serum/plasma: 62% vs. 2%, CSF: 47% vs. 0%) (P ​< ​0.002). In conclusion, our results suggest that stool has the highest diagnostic yield for EV-A71-infected HFMD. If stool is unavailable, rectal swabs can be collected to achieve a similar diagnostic yield. Otherwise, throat swabs may be useful in detecting positive samples. Although IgM in blood or CSF is diagnostically accurate, it lacks sensitivity, missing 40%-50% of cases. The higher proportion of severe cases and shorter interval between onset and sampling contributed to the increase in congruency between clinical testing and the serological reference standard

Long-term neurodevelopment outcomes of hand, foot and mouth disease inpatients infected with EV-A71 or CV-A16, a retrospective cohort study

Hand, foot and mouth disease (HFMD) is a common infectious disease in western Asia area and the full range of the long-term sequelae of HFMD remains poorly described. We conducted a retrospective hospital-based cohort study of HFMD patients with central nervous system (CNS) complications caused by EV-A71 or CV-A16 between 2010 and 2016. Patients were classified into three groups, including CNS only, autonomic nervous system (ANS) dysregulation, and cardiorespiratory failure. Neurologic examination, neurodevelopmental assessments, Magnetic Resonance Imaging (MRI) and lung function, were performed at follow up. Of the 176 patients followed up, 24 suffered CNS only, 133 ANS dysregulation, and 19 cardiorespiratory failure. Median follow-up period was 4.3 years (range [1.4-8.3]). The rate of neurological abnormalities was 25% (43 of 171) at discharge and 10% (17 of 171) at follow-up. The rates of poor outcome were significantly different between the three groups of complications in motor (28%, 38%, 71%) domain (p=0.020), but not for cognitive (20%, 24%, 35%), language (25%, 36%, 41%) and adaptive (24%, 16%, 26%) domains (&lt;i&gt;p&lt;/i&gt;&#x2009;=&#x2009;0.537, &lt;i&gt;p&lt;/i&gt;&#x2009;=&#x2009;0.551, &lt;i&gt;p&lt;/i&gt;&#x2009;=&#x2009;0.403). For children with ventilated during hospitalization, 41% patients (14 of 34) had an obstructive ventilatory defect, and one patient with scoliosis had mixed ventilatory dysfunction. Persistent abnormalities on brain MRI were 0% (0 of 7), 9% (2 of 23) and 57% (4 of 7) in CNS, ANS and cardiorespiratory failure group separately. Patients with HFMD may have abnormalities in neurological, motor, language, cognition, adaptive behaviour and respiratory function. Long-term follow-up programmes for children's neurodevelopmental and respiratory function may be warranted