Numerical Geodynamic Modeling of Continental Convergent Margins

Cardiovascular medicin

A Noninterior Path following Algorithm for Solving a Class of Multiobjective Programming Problems

Multiobjective programming problems have been widely applied to various engineering areas which include optimal design of an automotive engine, economics, and military strategies. In this paper, we propose a noninterior path following algorithm to solve a class of multiobjective programming problems. Under suitable conditions, a smooth path will be proven to exist. This can give a constructive proof of the existence of solutions and lead to an implementable globally convergent algorithm. Several numerical examples are given to illustrate the results of this paper

A Homeodomain-Containing Transcriptional Factor PoHtf1 Regulated the Development and Cellulase Expression in Penicillium oxalicum

Homeodomain-containing transcription factors (Htfs) play important roles in animals, fungi, and plants during some developmental processes. Here, a homeodomain-containing transcription factor PoHtf1 was functionally characterized in the cellulase-producing fungi Penicillium oxalicum 114-2. PoHtf1 was shown to participate in colony growth and conidiation through regulating the expression of its downstream transcription factor BrlA, the key regulator of conidiation in P. oxalicum 114-2. Additionally, PoHtf1 inhibited the expression of the major cellulase genes by coordinated regulation of cellulolytic regulators CreA, AmyR, ClrB, and XlnR. Furthermore, transcriptome analysis showed that PoHtf1 participated in the secondary metabolism including the pathway synthesizing conidial yellow pigment. These data show that PoHtf1 mediates the complex transcriptional-regulatory network cascade between developmental processes and cellulolytic gene expression in P. oxalicum 114-2. Our results should assist the development of strategies for the metabolic engineering of mutants for applications in the enzymatic hydrolysis for biochemical production

Another Class of Perfect Nonlinear Polynomial Functions

Perfect nonlinear (PN) functions have been an interesting subject of study for a long time and have applications in coding theory, cryptography, combinatorial designs, and so on. In this paper, the planarity of the trinomials xpk+1+ux2+vx2pk over GF(p2k) are presented. This class of PN functions are all EA-equivalent to x2

Functional Perspective and Implications of Gene Expression by Noncoding RNAs

Noncoding RNAs (ncRNAs) have gained widespread attention in recent years as a potentially new and crucial tool in biological regulation. Although they have been associated with a range of developmental processes and diseases, knowledge of the mechanisms by which they act is still surprisingly limited. To claim that almost entire mammalian genome is transcribed into functional noncoding transcripts remain controversial. Nevertheless, a small number of well executed studies on ncRNAs have given us important clues concerning the biological function of these molecules, and have successfully uncovered a few of their key functional and mechanistic themes, although the robustness of these models and classification schemes remains to be elucidated. Here, we summarize the new insights into ncRNAs field, discussing what is known about the genomic contexts, biological functions in human cancer, neural system disorders, stem cell (SC) self-renewal, and mechanisms of action of ncRNAs. Meanwhile, we have also tried to shed light on how the recent interest in ncRNAs is deeply rooted in biology′s longstanding concern of the evolution and function of genomes