Observation of a thermoelectric Hall plateau in the extreme quantum limit

The thermoelectric Hall effect is the generation of a transverse heat current upon applying an electric field in the presence of a magnetic field. Here we demonstrate that the thermoelectric Hall conductivity $\alpha_{xy}$ in the three-dimensional Dirac semimetal ZrTe$_5$ acquires a robust plateau in the extreme quantum limit of magnetic field. The plateau value is independent of the field strength, disorder strength, carrier concentration, or carrier sign. We explain this plateau theoretically and show that it is a unique signature of three-dimensional Dirac or Weyl electrons in the extreme quantum limit. We further find that other thermoelectric coefficients, such as the thermopower and Nernst coefficient, are greatly enhanced over their zero-field values even at relatively low fields.Comment: 17+21 pages, 3+14 figures; published versio

Aerodynamic Design of a Rectangular Wing in Subsonic Inviscid Flow by Surrogate-Based Optimization

The paper presents results of aerodynamic design of a rectangular wing in subsonic inviscid flow using surrogate-based local and global search algorithms. The aerodynamic design problem is formulated in Benchmark Cases 3 and 6 developed by the AIAA Applied Aerodynamics Discussion Group. Both involve lift-constrained drag minimization at a Mach number of 0.5 with relatively low lift coefficients (0.2625 and 0.375) with several nonlinear constraints and a small number design variables (up to 15). In this work, the local search is performed using variable-fidelity modelling and output space mapping, whereas the global search is performed using approximation-based surrogates. The paper presents the details of the computational modelling, shape parameterization, optimization algorithms, and results for each benchmark case. The approaches yield comparable results for Benchmark Case 3. Only the local search algorithm is applied to Benchmark Case 6. The results indicate the multimodality of that design case

Experimental study of a novel subcooling method based on liquid desiccant dehumidification for vapor-compression refrigeration systems

Refrigerant subcooling could increase the refrigerating capacity and potentially improve the performance of refrigeration systems. In this paper, a novel subcooling method is experimentally studied for the first time in a hybrid vapor compression refrigeration system. In this system, condensation heat (~40 °C) is used to drive an integrated subcooling cycle to subcool the refrigerant leaving the condenser, which significantly increases the system performance. Changes in system performance are measured as functions of the following variables: the mass flow rates of the dehumidification air, ambient air, dehumidification solution, regeneration solution, and spraying water. Comparisons are made between the proposed system and the traditional water-cooled chiller. The proposed system can achieve a larger degree of subcooling (15–20 °C); what’s more, it shows much higher performances than the traditional water-cooled chiller: COP and exergy efficiency of the chiller are improved by 18.6% and 27.9%, respectively. Performance of the integrated subcooling cycle is also evaluated; it has a low COP, with the maximum value of 0.13, due to the low-grade condensation heat; however, it has a pretty high exergy efficiency, with the maximum value of 0.28, which indicates the effective use of the low-grade heat. In addition, an economic analysis of the integrated subcooling cycle is made with a project life cycle of 15 years; the payback period varies from 2.4 to 3.2 years based on different electricity tariffs, and the savings to investment ratio is between 1.3 and 2.1, which indicates that the project is profitable

Author Correction: Magnesium intake and mortality due to liver diseases: Results from the Third National Health and Nutrition Examination Survey Cohort

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper

16S rRNA gene sequencing reveals the correlation between the gut microbiota and the susceptibility to pathological scars

The gut microbiome profile in patients with pathological scars remains rarely known, especially those patients who are susceptible to pathological scars. Previous studies demonstrated that gut microbial dysbiosis can promote the development of a series of diseases via the interaction between gut microbiota and host. The current study aimed to explore the gut microbiota of patients who are prone to suffer from pathological scars. 35 patients with pathological scars (PS group) and 40 patients with normal scars (NS group) were recruited for collection of fecal samples to sequence the 16S ribosomal RNA (16S rRNA) V3-V4 region of gut microbiota. Alpha diversity of gut microbiota showed a significant difference between NS group and PS group, and beta diversity indicated that the composition of gut microbiota in NS and PS participants was different, which implied that dysbiosis exhibits in patients who are susceptible to pathological scars. Based on phylum, genus, species levels, we demonstrated that the changing in some gut microbiota (Firmicutes; Bacteroides; Escherichia coli, etc.) may contribute to the occurrence or development of pathological scars. Moreover, the interaction network of gut microbiota in NS and PS group clearly revealed the different interaction model of each group. Our study has preliminary confirmed that dysbiosis exhibits in patients who are susceptible to pathological scars, and provide a new insight regarding the role of the gut microbiome in PS development and progression

Estimation of empirical null using a mixture of normals and its use in local false discovery rate

When high dimensional microarray data is given, it is of interest to select significant genes by controlling a given level of Type-I error. One popular way to control the level is the false discovery rate (FDR). This paper considers gene selection based on the local false discovery rate. In most of the previous studies, the null distribution of gene expression is commonly assumed to be a normal distribution. However, if the null distribution has heavier tail than that of normal, there may exist too many false discoveries leading to the failure of controlling the given level of FDR. We propose a novel procedure which enriches a class of null distribution based on a mixture of normals. We present simulation studies to show that our proposed procedure is less sensitive to variation of null distribution than local false discovery rate with a single normal for the null. We also provide real example of gene expression profiles of antigen-specific human CD8+ T-lymphocytes treated with cytokine Interleukin-2 (IL-2) and Interleukin-15 (IL-15) for comparison.Local false discovery rate Normal mixture Sparsity Gene selection

Experimental study of a novel subcooling method based on liquid desiccant dehumidification for vapor-compression refrigeration systems.

Refrigerant subcooling could increase the refrigerating capacity and potentially improve the performance of refrigeration systems. In this paper, a novel subcooling method is experimentally studied for the first time in a hybrid vapor compression refrigeration system. In this system, condensation heat (~40 °C) is used to drive an integrated subcooling cycle to subcool the refrigerant leaving the condenser, which significantly increases the system performance. Changes in system performance are measured as functions of the following variables: the mass flow rates of the dehumidification air, ambient air, dehumidification solution, regeneration solution, and spraying water. Comparisons are made between the proposed system and the traditional water-cooled chiller. The proposed system can achieve a larger degree of subcooling (15–20 °C); what’s more, it shows much higher performances than the traditional water-cooled chiller: COP and exergy efficiency of the chiller are improved by 18.6% and 27.9%, respectively. Performance of the integrated subcooling cycle is also evaluated; it has a low COP, with the maximum value of 0.13, due to the low-grade condensation heat; however, it has a pretty high exergy efficiency, with the maximum value of 0.28, which indicates the effective use of the low-grade heat. In addition, an economic analysis of the integrated subcooling cycle is made with a project life cycle of 15 years; the payback period varies from 2.4 to 3.2 years based on different electricity tariffs, and the savings to investment ratio is between 1.3 and 2.1, which indicates that the project is profitable

The application value of mean red blood cell volume and red blood cell volume distribution width combined with total serum bilirubin in the early screening of neonatal hemolytic disease

Abstract Background The hemolytic nature of hemolytic disease of the newborn (HDN) is described as the abnormal destruction and decomposition of red blood cells, causing heterogeneous manifestations such as abnormal red blood cell volume and morphology. Mean corpuscular volume (MCV) and red blood cell volume distribution width (RDW) are commonly used parameters related to red blood cell volume. Total serum bilirubin (TSB) is routinely monitored among newborns. This study aims to explore the value of MCV and RDW, combined with TSB, to improve the efficiency of HDN diagnosis. Methods Three hundred eighty-eight children with HDN and 371 children with non-HDN pathological jaundice who were diagnosed and treated in the neonatal department of our hospital from January 2019 to December 2020 were included in the study. Clinical data collected include examination results of laboratory indicators, such as MCV, coefficient of variation of red blood cell volume distribution width (RDW-CV), standard deviation of red blood cell volume distribution width (RDW-SD), and TSB. The differences in the indicators between the two groups of children were retrospectively analyzed. Results 1) The detection rate of HDN in children in the early group was higher than that in the late group (P  163.3 μmol/L, MCV > 96.35fL, and RDW-CV > 16.05%, the diagnosis rate of HDN increased (P  96.35fL or RDW-CV > 16.05%, children with jaundice in three days of birth (especially children with TSB > 163.3 μmol/L) should be screened for HDN. A combination of TSB, MCV, and RDW-CV can improve the early detection rate of HDN, contribute to reduce the readmission rate and risk of hyperbilirubinemia