1,668 research outputs found
1,3-Bis(2-nitrophenoxy)propan-2-ol
In the title compound, C15H14N2O7, the planes of the two benzene rings form a dihedral angle of 33.16 (17)°. In the crystal, intermolecular hydrogen bonds involveing the OH group and nitro O atoms link the molecules into chains propagating along the a axis
Piperidinium bis(2-oxidobenzoato-κ2 O 1,O 2)borate
The asymmetric unit of the title compound, C5H12N+·C14H8BO6
− or [C5H12N][BO4(C7H4O)2], contains two piperidinium cations and two bis(salicylato)borate anions. The coordination geometries around the B atoms are distorted tetrahedral. In the two molecules, the aromatic rings are oriented at dihedral angles of 76.27 (3) and 83.86 (3)°. The rings containing B atoms have twist-boat conformations, while the two cations adopt chair conformations. In the crystal, the component species are linked by N—H⋯O hydrogen bonds. In the crystal structure, intra- and intermolecular N—H⋯O hydrogen bonds link the molecules
Refined mapping of loss of heterozygosity in Chinese sporadic gastric carcinoma
The aim of this study is to explore precise deleted regions where the candidate tumor suppressor genes might be located in Chinese sporadic gastric carcinoma. By searching in Genothon, NCBI and GDB databases, 145 polymorphic microsatellite markers were chosen, at a mean density of approximately one marker every 2 - 4 cM, covering 15 chromosomes. These polymorphic microsatellite markers in gastric carcinoma and adjacent tissue were analyzed via PCR. PCR products were submitted to electrophoresis on an ABI 3730 DNA sequencer. Genemapper3.2 software was used for LOH (Loss of Heterozygosity) scanning and analysis. Comparison between LOH frequency and clinicopathological factors was performed by Fisher’s exact test. 26 refined regions were mapped as candidate regions for TSGs (Tumor suppression genes) in Chinese sporadic gastric cancer. Associations between LOH and clinical information indicated that 6 loci was associated with pTNM stage, 5 with Lauren's type, 4 with lymph nodes metastasis and another 2 with distant metastasis. Through refined deletion mapping, 26 candidate regions, where TSGs may be located, were found and 17 loci were proposed to be used as clinical markers in Chinese sporadic gastric cancer.Keywords: Gastric carcinoma, refined mapping, loss of heterozygosity (LOH), tumor suppressor genes (TSGs), tumor markersAfrican Journal of Biotechnology Vol. 9(35), pp. 5754-5761, 30 August, 201
Source attack of decoy-state quantum key distribution using phase information
Quantum key distribution (QKD) utilizes the laws of quantum mechanics to
achieve information-theoretically secure key generation. This field is now
approaching the stage of commercialization, but many practical QKD systems
still suffer from security loopholes due to imperfect devices. In fact,
practical attacks have successfully been demonstrated. Fortunately, most of
them only exploit detection-side loopholes which are now closed by the recent
idea of measurement-device-independent QKD. On the other hand, little attention
is paid to the source which may still leave QKD systems insecure. In this work,
we propose and demonstrate an attack that exploits a source-side loophole
existing in qubit-based QKD systems using a weak coherent state source and
decoy states. Specifically, by implementing a linear-optics
unambiguous-state-discrimination measurement, we show that the security of a
system without phase randomization --- which is a step assumed in conventional
security analyses but sometimes neglected in practice --- can be compromised.
We conclude that implementing phase randomization is essential to the security
of decoy-state QKD systems under current security analyses.Comment: 12 pages, 5 figure
STGC3 inhibits xenograft tumor growth of nasopharyngeal carcinoma cells by altering the expression of proteins associated with apoptosis
STGC3 is a potential tumor suppressor that inhibits the growth of the nasopharyngeal carcinoma cell line CNE2; the expression of this protein is reduced in nasopharyngeal carcinoma compared with normal nasopharyngeal tissue. In this study, we investigated the tumor-suppressing activity of STGC3 in nude mice injected subcutaneously with Tet/pTRE-STGC3/CNE2 cells. STGC3 expression was induced by the intraperitoneal injection of doxycycline (Dox). The volume mean of Tet/pTRE-STGC3/CNE2+Dox xenografts was smaller than that of Tet/pTRE/CNE2+Dox xenografts. In addition, Tet/pTRE-STGC3/CNE2+Dox xenografts showed an increase in the percentage of apoptotic cells, a decrease in Bcl-2 protein expression and an increase in Bax protein expression. A proteomic approach was used to assess the protein expression profile associated with STGC3-mediated apoptosis. Western blotting confirmed the differential up-regulation of prohibitin seen in proteomic analysis. These results indicate that overexpression of STGC3 inhibits xenograft growth in nude mice by enhancing apoptotic cell death through altered expression of apoptosis-related proteins such as Bcl-2, Bax and prohibitin. These data contribute to our understanding of the function of STGC3 in human nasopharyngeal carcinoma and provide new clues for investigating other STGC3-associated tumors
Study on the spatial distribution pattern of Cx40 gap junctions in the atria of patients with coronary heart disease
Background: The aim of this study was to evaluate the association between atrial fibrillation
and atrial dilation and the spatial distribution pattern of connexin 40 in the atria of patients
with coronary heart disease.
Methods: Twenty-six patients with coronary heart disease undergoing cardiac surgery for
coronary artery bypass graft were investigated and were divided into three groups according to
the left atrial size and rhythm, atrial fibrillation and left atrial dilatation (AF+AD), sinus
rhythm and left atrial dilation (SR+AD) and sinus rhythm as control group SR. The spatial
distribution patterns of Cx40 were evaluated using confocal laser scanning microscopy assay.
Results: No significant differences were observed in the size and density of Cx40 gap junction
in the right atrium among all three groups (p > 0.05). Compared with the control group, the size
of Cx40 disk area in termination links and in lateral abutment in left atrium was markedly
larger in AF+AD group and SR+AD group than those of the controls (p < 0.01). A comparison
of size and density of Cx40 gap junction in the left atrium in the AF+AD group and SR+AD
group did not show significant differences.
Conclusions: The present study has shown altered gap junction distribution in coronary
heart disease resulting from atrial dilation and atrial fibrillation. A decrease in the size and density
of Cx40 gap junction was observed in patients with atrial dilation, which could be an important
factor in the initiation and maintenance of atrial fibrillation. (Cardiol J 2008; 15: 50-56
- …