Generalized Two-Dimensional Quaternion Principal Component Analysis with Weighting for Color Image Recognition

A generalized two-dimensional quaternion principal component analysis (G2DQPCA) approach with weighting is presented for color image analysis. As a general framework of 2DQPCA, G2DQPCA is flexible to adapt different constraints or requirements by imposing $L_{p}$ norms both on the constraint function and the objective function. The gradient operator of quaternion vector functions is redefined by the structure-preserving gradient operator of real vector function. Under the framework of minorization-maximization (MM), an iterative algorithm is developed to obtain the optimal closed-form solution of G2DQPCA. The projection vectors generated by the deflating scheme are required to be orthogonal to each other. A weighting matrix is defined to magnify the effect of main features. The weighted projection bases remain the accuracy of face recognition unchanged or moving in a tight range as the number of features increases. The numerical results based on the real face databases validate that the newly proposed method performs better than the state-of-the-art algorithms.Comment: 15 pages, 15 figure

Refined mapping of loss of heterozygosity in Chinese sporadic gastric carcinoma

The aim of this study is to explore precise deleted regions where the candidate tumor suppressor genes might be located in Chinese sporadic gastric carcinoma. By searching in Genothon, NCBI and GDB databases, 145 polymorphic microsatellite markers were chosen, at a mean density of approximately one marker every 2 - 4 cM, covering 15 chromosomes. These polymorphic microsatellite markers in gastric carcinoma and adjacent tissue were analyzed via PCR. PCR products were submitted to electrophoresis on an ABI 3730 DNA sequencer. Genemapper3.2 software was used for LOH (Loss of Heterozygosity) scanning and analysis. Comparison between LOH frequency and clinicopathological factors was performed by Fisher’s exact test. 26 refined regions were mapped as candidate regions for TSGs (Tumor suppression genes) in Chinese sporadic gastric cancer. Associations between LOH and clinical information indicated that 6 loci was associated with pTNM stage, 5 with Lauren's type, 4 with lymph nodes metastasis and another 2 with distant metastasis. Through refined deletion mapping, 26 candidate regions, where TSGs may be located, were found and 17 loci were proposed to be used as clinical markers in Chinese sporadic gastric cancer.Keywords: Gastric carcinoma, refined mapping, loss of heterozygosity (LOH), tumor suppressor genes (TSGs), tumor markersAfrican Journal of Biotechnology Vol. 9(35), pp. 5754-5761, 30 August, 201

Extramedullary Plasmacytoma Involving the Bilateral Adrenal Glands on MR Imaging

We report here on a 64-year-old woman with extramedullary plasmacytoma involving the bilateral adrenal glands. Primary adrenal extramedullary plasmacytoma is extremely rare and only three cases of extramedullary plasmacytoma in the unilateral adrenal gland have currently been reported on. This case is of interest in that the bilateral adrenals were involved. In this article, we present the MRI findings and we briefly review the relevant literature

Pharmacokinetics of diltiazem hydrochloride delay-onset sustained-release pellet capsules in healthy volunteers

Embora a farmacocinética (PK) do cloridrato de diltiazem nas formas de comprimidos de liberação imediata e cápsulas de liberação modificada em ensaios clínicos já tenha sido relatada, a pesquisa da PK do cloridrato de diltiazem na forma de cápsulas com peletes de liberação retardada e sustentada ainda é muito importante. Neste trabalho, propusemos avaliar a farmacocinética do cloridrato de diltiazem administrado através desta nova forma farmacêutica em voluntários chineses sadios, assim como a influência da ingestão de alimentos neste perfil farmacocinético. Foi realizado um ensaio clínico aberto, randomizado e paralelo em 36 voluntários, que receberam dose oral única de 90 mg, 180 mg ou 270 mg e dose múltiplas (90 mg/d × 6 d) pela mesma via de administração. Para avaliar o efeito da ingestão de alimentos sobre a PK do diltiazem foi realizada a administração de dose única (360 mg) em 24 voluntários chineses sadios. A concentração plasmática do diltiazem foi determinada por Cromatografia Liquida de Alta Eficiência em fase reversa (CLAE-FR) e os principais parâmetros farmacocinéticos foram analisados através do emprego do software PKSolver (Ver 2.0). O ensaio de farmacocinética clínica foi conduzido na clínica Pharmacological Center (No.JDX1999064) do Hospital de Xiangya, Central South University, China. Os parâmetros PK obtidos indicaram que a nova formulação de cápsulas de liberação retardada e sustentada de cloridrato de diltiazem possue marcantes características de liberação retardada e controlada do fármaco.The pharmacokinetics (PK) of ordinary tablets and sustained release capsules of diltiazem hydrochloride in human clinical trials had been studied. The PK of diltiazem hydrochloride delay-onset sustained-release pellet capsules, a new dosage form, has not been reported, although it is very important to clinical use. In this paper, we investigated the PK of diltiazem hydrochloride delay-onset sustained-release pellet capsules and the food influence in Chinese healthy volunteers. The PK parameters indicated that the diltiazem hydrochloride delay-onset sustained-release pellet capsules appeared marked characteristics of delayed and controlled release. An opened-label, randomized and parallel clinical trial was conducted in 36 Chinese healthy volunteers with single oral dose (90 mg, 180 mg or 270 mg) and a multiple oral dose (90 mg d-1×6 d) administration. The effect of food on the PK of one single oral dose (360 mg) was investigated in 24 healthy Chinese volunteers. Plasma diltiazem concentration was determined by reversed-phase high-performance liquid chromatography (RP-HPLC) and the main pharmacokinetic parameters were analyzed by PKSolver (Ver 2.0). All clinical studies were conducted in the Clinical Pharmacological Center (No. JDX1999064) of Xiangya Hospital Affiliated Central South University, China. The PK parameters suggested that the new formulation had marked characteristics of delayed and controlled release of diltiazem, and food intake did not alter significantly diltiazem pharmacokinetic parameters

Nonlinear Drift Resonance Between Charged Particles and Ultralow Frequency Waves: Theory and Observations

In Earth’s inner magnetosphere, electromagnetic waves in the ultralow frequency (ULF) range play an important role in accelerating and diffusing charged particles via drift resonance. In conventional drift resonance theory, linearization is applied under the assumption of weak waveâ particle energy exchange so particle trajectories are unperturbed. For ULF waves with larger amplitudes and/or durations, however, the conventional theory becomes inaccurate since particle trajectories are strongly perturbed. Here we extend the drift resonance theory into a nonlinear regime, to formulate nonlinear trapping of particles in a waveâ carried potential well, and predict the corresponding observable signatures such as rolledâ up structures in particle energy spectrum. After considering how this manifests in particle data with finite energy resolution, we compare the predicted signatures with Van Allen Probes observations. Their good agreement provides the first observational evidence for the occurrence of nonlinear drift resonance, highlighting the importance of nonlinear effects in magnetospheric particle dynamics under ULF waves.Plain Language SummaryIn Earth’s Van Allen radiation belts, ultralow frequency (ULF) waves in the frequency range between 2 and 22 mHz play a crucial role in accelerating charged particles via a resonant process named drift resonance. When such a resonance occurs, a resonant particle observes a constant phase of the wave electric field, and it experiences a net energy excursion. In previous studies of drift resonance, a linearization approach is often applied with assumption of a weak waveâ particle energy exchange. In this study, we extend the linear theory into the nonlinear regime to formulate the particle behavior in the ULF wave field, and predict characteristic signatures of the nonlinear process observable from a virtual magnetospheric spacecraft. Such newly predicted signatures are found to agree with observations from the National Aeronautics and Space Administration’s Van Allen Probes, which provides the first identification of nonlinear drift resonance and highlights the importance of nonlinear effects in ULF waveâ particle interactions in the Van Allen radiation belts.Key PointsThe nonlinear theory of ULF waveâ particle drift resonance is developed to formulate the behavior of charged particles in ULF wave fieldSignatures of nonlinear drift resonance include rolledâ up structures and/or multiperiod oscillations in the particle energy spectrumIn situ observations of the newly predicted signatures validate the theory and provide a first identification of nonlinear drift resonancePeer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/146432/1/grl57916_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/146432/2/grl57916.pd