Influence of different cover ratios on Gas-particle flow characteristics of a centrally-fuel-rich primary air burner: experiment and simulation

AbstractThe flow field for different cover ratios within a three-level conical ring concentrator of a centrally-fuel-rich swirl coal combustion burner has been studied both experimentally and numerically. A particle dynamics anemometer measurement system was employed in the study to measure velocity and particle volume flux after the outlet of third-level ring. And the numerical simulations were used to calculate the flow field in the conical ring region. In each cross-section, after the outlet of third-level ring, concentration ratio for each cover ratio is always larger than 2. With conical ring concentrator in the primary air tube, the coal concentration can be concentrated to a suitable range. In the cross-sections 0.5<x/D<4.0, as cover ratio increases, concentration ratio decreases and resistance coefficient increases

ModelGiF: Gradient Fields for Model Functional Distance

The last decade has witnessed the success of deep learning and the surge of publicly released trained models, which necessitates the quantification of the model functional distance for various purposes. However, quantifying the model functional distance is always challenging due to the opacity in inner workings and the heterogeneity in architectures or tasks. Inspired by the concept of "field" in physics, in this work we introduce Model Gradient Field (abbr. ModelGiF) to extract homogeneous representations from the heterogeneous pre-trained models. Our main assumption underlying ModelGiF is that each pre-trained deep model uniquely determines a ModelGiF over the input space. The distance between models can thus be measured by the similarity between their ModelGiFs. We validate the effectiveness of the proposed ModelGiF with a suite of testbeds, including task relatedness estimation, intellectual property protection, and model unlearning verification. Experimental results demonstrate the versatility of the proposed ModelGiF on these tasks, with significantly superiority performance to state-of-the-art competitors. Codes are available at https://github.com/zju-vipa/modelgif.Comment: ICCV 202

Magnetoresistance in Thin Permalloy Film (10nm-thick and 30-200nm-wide) Nanocontacts Fabricated by e-Beam Lithography

In this paper we show spin dependent transport experiments in nanoconstrictions ranging from 30 to 200nm. These nanoconstrictions were fabricated combining electron beam lithography and thin film deposition techniques. Two types of geometries have been fabricated and investigated. We compare the experimental results with the theoretical estimation of the electrical resistance. Finally we show that the magnetoresistance for the different geometries does not scale with the resistance of the structure and obtain drops in voltage of 20mV at 20Oe.Comment: 15 pages, 4 figures. Accepted by AP

Numerical Simulation of the Flow Field around Generic Formula One

The steady Reynolds-Averaged Navier-Stokes (RANS) method with the Realizable k turbulence model was used to analyze the flow field around a race car (generic Formula One). This study was conducted using the ANSYS software package. The numerical simulations were conducted at a Reynolds number based on the race car model (14.9×106). The time-averaged velocity field, flow topology, velocity magnitude, static pressure magnitude and vortex regions of the flow fields are presented in this paper. The measurements were performed on the vertical and cross-sectional planes. The results are presented graphically, showing the main characteristics of the flow field around the whole race car, whereas most previous studies only mention the flow field around individual components of race cars. The Realizable k turbulence model results showed consistency with the valuable validation data, which helps to elucidate the flow field around a model generic Formula one race car

Provable Routing Analysis of Programmable Photonics

Programmable photonic integrated circuits (PPICs) are an emerging technology recently proposed as an alternative to custom-designed application-specific integrated photonics. Light routing is one of the most important functions that need to be realized on a PPIC. Previous literature has investigated the light routing problem from an algorithmic or experimental perspective, e.g., adopting graph theory to route an optical signal. In this paper, we also focus on the light routing problem, but from a complementary and theoretical perspective, to answer questions about what is possible to be routed. Specifically, we demonstrate that not all path lengths (defined as the number of tunable basic units that an optical signal traverses) can be realized on a square-mesh PPIC, and a rigorous realizability condition is proposed and proved. We further consider multi-path routing, where we provide an analytical expression on path length sum, upper bounds on path length mean/variance, and the maximum number of realizable paths. All of our conclusions are proven mathematically. Illustrative potential optical applications using our observations are also presented

Thin film aluminum nitride surface acoustic wave resonators for quantum acoustodynamics

The quantum excitations of macroscopic surface acoustic waves (SAWs) have been tailored to control, communicate and transduce stationary and flying quantum states. However, the limited lifetime of this hybrid quantum systems remains critical obstacles to extend their applications in quantum information processing. Here we present the potentials of thin film aluminum nitride to on-chip integrate phonons with superconducting qubits over previous bulk piezoelectric substrates. We have reported high-quality thin film GHz-SAW resonators with the highest internal quality factor Qi of 5 e4 at the single-phonon level. The internal loss of SAW resonators are systematically investigated with tuning the parameters of sample layout, power and temperature. Our results manifest that SAWs on piezoelectric films are readily integrable with standard fabrication of Josephson junction quantum circuits, and offer excellent acoustic platforms for the high-coherence quantum acoustodynamics architectures.Comment: 10 pages, 4 figure

Zoledronate extends healthspan and survival via the mevalonate pathway in a FOXO-dependent manner

Over recent decades, increased longevity has not been paralleled by extended healthspan, resulting in more years spent with multiple diseases in older age. As such, interventions to improve healthspan are urgently required. Zoledronate is a nitrogen containing bisphosphonate, which inhibits the farnesyl pyrophosphate synthase (FPPS) enzyme, central to the mevalonate pathway. It is already used clinically to prevent fractures in osteoporotic patients, who have been reported to derive unexpected and unexplained survival benefits. Using Drosophila as a model we determined the effects of Zoledronate on lifespan, parameters of healthspan (climbing ability and intestinal dysplasia) and the ability to confer resistance to oxidative stress using a combination of genetically manipulated Drosophila strains and Western blotting. Our study shows that Zoledronate extended lifespan, improved climbing activity and reduced intestinal epithelial dysplasia and permeability with age. Mechanistic studies showed that Zoledronate conferred resistance to oxidative stress and reduced accumulation of X-ray-induced DNA damage via inhibition of FPPS. Moreover, Zoledronate was associated with inhibition of pAKT in the mTOR pathway downstream of the mevalonate pathway and required dFOXO for its action, both molecules associated with increased longevity. Taken together, our work indicates that Zoledronate, a drug already widely used to prevent osteoporosis and dosed only once a year, modulates important mechanisms of ageing. Its repurposing holds great promise as a treatment to improve healthspan

Optical Coherence Tomography Angiography Reveals Distinct Retinal Structural and Microvascular Abnormalities in Cerebrovascular Disease.

Cerebrovascular disease (CeVD) is one of the leading global causes of death and severe disability. To date, retinal microangiopathy has become a reflection of cerebral microangiopathy, mirroring the vascular pathological modifications in vivo. To evaluate the retinal structure and microvasculature in patients with CeVD, we conducted a cross-sectional study in Zhongshan Ophthalmic Center and Department of Neurology of Third Affiliated Hospital, Sun Yat-sen University using optical coherence tomography angiography (OCTA). CeVD patients (n = 121; 238 eyes) and healthy controls (n = 44; 57 eyes) were included in the analysis. The CeVD group showed significant thinning of the peripapillary retinal nerve fiber layer (pRNFL) thickness in the temporal and nasal quadrants, and thinning of the macular ganglion cell-inner plexiform layer (GC-IPL) in the inferior quadrant, while macular microvasculature reduction was prominent in all nine quadrants. There were significant correlations between OCTA parameters, visual acuity, and transcranial doppler parameters in the CeVD group. The specific structural parameters combining microvasculature indices showed the best diagnostic accuracies (AUC = 0.918) to discriminate CeVD group from healthy controls. To conclude, we proved that OCTA reveals specific patterns of retinal structural changes and extensive macular microvascular changes in CeVD. Additionally, these retinal abnormalities could prove useful disease biomarkers in the management of individuals at high risk of debilitating complications from a cerebrovascular event

The role of anti-aquaporin 4 antibody in the conversion of acute brainstem syndrome to neuromyelitis optica

Background: Acute brainstem syndrome (ABS) may herald multiple sclerosis (MS), neuromyelitis optica (NMO), or occur as an isolated syndrome. The aquaporin 4 (AQP4)-specific serum autoantibody, NMO-IgG, is a biomarker for NMO. However, the role of anti-AQP4 antibody in the conversion of ABS to NMO is unclear.Methods: Thirty-one patients with first-event ABS were divided into two groups according to the presence of anti-AQP4 antibodies, their clinical features and outcomes were retrospectively analyzed.Results: Fourteen of 31 patients (45.16 %) were seropositive for NMO-IgG. The 71.43 % of anti-AQP4 (+) ABS patients converted to NMO, while only 11.76 % of anti-AQP4 (-) ABS patients progressed to NMO. Anti-AQP4 (+) ABS patients demonstrated a higher IgG index (0.68 ± 0.43 vs 0.42 ± 0.13, p

Gab2 and Gab3 Redundantly Suppress Colitis by Modulating Macrophage and CD8+ T-Cell Activation

Inflammatory Bowel Disease (IBD) is a multi-factorial chronic inflammation of the gastrointestinal tract prognostically linked to CD8+ T-cells, but little is known about their mechanism of activation during initiation of colitis. Here, Grb2-associated binding 2/3 adaptor protein double knockout mice (Gab2/3−/−) were generated. Gab2/3−/− mice, but not single knockout mice, developed spontaneous colitis. To analyze the cellular mechanism, reciprocal bone marrow (BM) transplantation demonstrated a Gab2/3−/− hematopoietic disease-initiating process. Adoptive transfer showed individual roles for macrophages and T-cells in promoting colitis development in vivo. In spontaneous disease, intestinal intraepithelial CD8+ but much fewer CD4+, T-cells from Gab2/3−/− mice with rectal prolapse were more proliferative. To analyze the molecular mechanism, reduced PI3-kinase/Akt/mTORC1 was observed in macrophages and T-cells, with interleukin (IL)-2 stimulated T-cells showing increased pSTAT5. These results illustrate the importance of Gab2/3 collectively in signaling responses required to control macrophage and CD8+ T-cell activation and suppress chronic colitis