Asymptotic Normality of a Class of Adaptive Statistics with Applications to Synthetic Data Methods for Censored Regression

AbstractMotivated by regression analysis of censored survival data, we develop herein a general asymptotic distribution theory for estimators defined by estimating equations of the form ∑ni=1ξ (wi, θ, Ĝn) = 0, in which wi represents observed data, θ is an unknown parameter to be estimated, and Ĝn represents an estimate of some unknown underlying distribution. This general theory is used to establish asymptotic normality of synthetic least squares estimates in censored regression models and to evaluate the covariance matrices of the limiting normal distributions

A tunable radiation source by coupling laser-plasma-generated electrons to a periodic structure

Near-infrared radiation around 1000 nm generated from the interaction of a high-density MeV electron beam, obtained by impinging an intense ultrashort laser pulse on a solid target, with a metal grating is observed experimentally. Theoretical modeling and particle-in-cell simulation suggest that the radiation is caused by the Smith-Purcell mechanism. The results here indicate that tunable terahertz radiation with tens GV=m field strength can be achieved by using appropriate grating parameter

Geometric nonlinear vibration analysis for pretensioned rectangular orthotropic membrane

The geometric nonlinear vibrations of pretensioned orthotropic membrane with four edges fixed, which is commonly applied in building membrane structure, are studied. The nonlinear partial differential governing equations are derived by von Kármán’s large deflection theory and D’Alembert’s principle. Because of the strong nonlinearity of governing equations, the homotopy perturbation method (HPM) to solve them is applied. The approximate analytical solution of the vibration frequency and displacement function is obtained. In the computational example, the frequency, vibration mode and displacement as well as the time curve of each feature point are analyzed. It is proved that HPM is an effective, simple and high-precision method to solve the geometric nonlinear vibration problem of membrane structures. These results provide some valuable computational basis for the vibration control and dynamic design of building and other analogous membrane structures.Вивчено геометрично нелінійні коливання попередньо напруженої ортотропної мембрани з чотирма фіксованими краями, яка звичайно використовується в будівельних мембранних конструкціях. Нелінійні рівняння динаміки в частинних похідних отримано на базі теорії фон Кармана про великі прогини і принципу Д‘Алямбера. Застосовано метод гомотопічного збурення для розв’язування отриманих сильно нелінійних рівнянь. Отримано наближений аналітичний розвязок для частоти коливань і функції зміщень. У числовому прикладі проаналізовано частоти, форми коливань, зміщення і залежні від часу криві у кожній характерній точці. Доведено, що цей метод є ефективним, простим і високоточним для розвязування задач про геометрично нелінійні коливання мембранних конструкцій. Ці результати створюють певну корисну базу для обчислення задач про управління коливаннями і динамічне конструювання будівельних та інших аналогічних мембранних конструкцій

Relationship between HPV16/18 E6 and р53, р21waf1, MDM2, Ki67 and cyclin D1 expression in esophageal squamous cell carcinoma: comparative study by using tissue microarray technology

Aim: To investigate the role of human papillomavirus (HPV) HPV16/18 E6 oncogene in the carcinogenesis of esophageal cell carcinoma (ESCC). Materials and Methods: Tissue microarray (TMA) block was constructed from 60 cases of paraffin-embedded ESCC tissues and pair-matched controls (adjacent normal epithelium). Immunohistochemistry (IHC) methods were applied to detect the expression of HPV16/18 E6, p53, p21Waf1, MDM2, Ki67 and cyclin D1 proteins on TMA slides. In situ hybridization (ISH) targeting HPV gene was also used. Results: In ESCC samples, 18.3% (11/60) were revealed HPV16/18 E6 positive by IHC, while 40.0% (24/60) HPV positive by ISH; HPV16/18 E6 expression was significantly higher than that of control samples. In ESCC samples, the expressions of p53, p21Waf1, Cyclin D1, MDM2 and Ki67 were recorded in 60.0% (36/60), 40.0% (24/60), 51.7% (31/60), 65.0% (39/60) and 88.3% (53/60) cases respectively, In ESCC samples, p53, MDM2 and Ki67 expression correlated with the HPV16/18 E6 expression (p < 0.01), p21Waf1 expression — with these of MDM2 and cyclin D1 (p < 0.01) whilst expression of Ki67 — with ESCC grade (p < 0.01). Conclusion: HPV might be one of etiological factor of esophageal carcinoma in Shantou, China. p53, MDM2 proteins may play important roles in the pathogenesis of HPV-associated ESCC.Цель: исследовать роль онкогена HPV16/18 E6 вируса папилломы человека (HPV) в развитии плоскоклеточной карциномы пищевода (ESCC). Материалы и методы: исследованы 60 образцов ESCC и контрольные образцы нетрансформированной ткани (парафиновые блоки). Для выявления экспрессии белков HPV16/18 E6, p53, p21Waf1, MDM2, Ki67 и циклина D1 в срезах для тканевых микрочипов (tissue microarray, TMA) применен метод иммуногистохимии (IHC), для определения экспрессии генов HPV применяли гибридизацию in situ (ISH). Результаты: методами IHC, экспрессия HPV16/18 E6 выявлена в 18,3% (11/60) случаев ESCC, в то время как по результатам метода ISH, 40,0% (24/60) образцов признаны HPV-позитивными. В образ­цах ESCC экспрессия p53, p21Waf1, циклина D1, MDM2 и Ki67 выявлена в 60,0% (36/60), 40,0% (24/60), 51,7% (31/60), 65,0% (39/60) и 88,3% (53/60) случаев соответ­ственно, причем экспрессия p53, MDM2 и Ki67 коррелировала с экспрессией HPV16/18 E6 (p < 0,01), экспрессия p21Waf1 — с таковой MDM2 и циклина D1, а экспрессия Ki67 — со стадией развития опухоли (p < 0.01). Выводы: HPV может являться одним из этиологических факторов развития рака пищевода в провинции Шанту, Китай. Белки p53 и MDM2 могут принимать участие в патогенезе плоскоклеточного рака пищевода, ассоциированного с вирусом папилломатоза

Molecular characterization of different Triticum monococcum ssp. monococcum Glu-A1^mx alleles

High-molecular-weight glutenin subunits (HMW-GSs) are important seed storage proteins associated with bread-making quality in common wheat (Triticum aestivum L., 2n = 6x = 42, AABBDD). Variation in the Glu-A1x locus in common wheat is scare. Diploid Triticum monococcum ssp. monococcum (2n = 2x = 14, AmAm) is the first cultivated wheat. In the present study, allelic variations at the Glu-A1mx locus were systematically investigated in 197 T. monococcum ssp. monococcum accessions. Out of the 8 detected Glu-A1mx alleles, 5 were novel, including Glu-A1m-b, Glu-A1m-c, Glu-A1m-d, Glu-A1m-g, and Glu-A1m-h. This diversity is higher than that of common wheat. Compared with 1Ax1 and 1Ax2*, which are present in common wheat, these alleles contained three deletions/insertions as well as some single nucleotide polymorphism variations that might affect the elastic properties of wheat flour. New variations in T. monococcum probably occurred after the divergence between A and Am and are excluded in common wheat populations. These allelic variations could be used as novel resources to further improve wheat quality

A study of charged kappa in J/ψ→K±Ksπ∓π0J/\psi \to K^{\pm} K_s \pi^{\mp} \pi^0

Based on $58 \times 10^6$ $J/\psi$ events collected by BESII, the decay $J/\psi \to K^{\pm} K_s \pi^{\mp} \pi^0$ is studied. In the invariant mass spectrum recoiling against the charged $K^*(892)^{\pm}$, the charged $\kappa$ particle is found as a low mass enhancement. If a Breit-Wigner function of constant width is used to parameterize the kappa, its pole locates at $(849 \pm 77 ^{+18}_{-14}) -i (256 \pm 40 ^{+46}_{-22})$ MeV/$c^2$. Also in this channel, the decay $J/\psi \to K^*(892)^+ K^*(892)^-$ is observed for the first time. Its branching ratio is $(1.00 \pm 0.19 ^{+0.11}_{-0.32}) \times 10^{-3}$.Comment: 14 pages, 4 figure

Measurements of the observed cross sections for e+e−→e^+e^-\to exclusive light hadrons containing π0π0\pi^0\pi^0 at s=3.773\sqrt s= 3.773, 3.650 and 3.6648 GeV

By analyzing the data sets of 17.3, 6.5 and 1.0 pb$^{-1}$ taken, respectively, at $\sqrt s= 3.773$, 3.650 and 3.6648 GeV with the BES-II detector at the BEPC collider, we measure the observed cross sections for $e^+e^-\to \pi^+\pi^-\pi^0\pi^0$, $K^+K^-\pi^0\pi^0$, $2(\pi^+\pi^-\pi^0)$, $K^+K^-\pi^+\pi^-\pi^0\pi^0$ and $3(\pi^+\pi^-)\pi^0\pi^0$ at the three energy points. Based on these cross sections we set the upper limits on the observed cross sections and the branching fractions for $\psi(3770)$ decay into these final states at 90% C.L..Comment: 7 pages, 2 figure

Partial wave analysis of J/\psi \to \gamma \phi \phi

Using $5.8 \times 10^7 J/\psi$ events collected in the BESII detector, the radiative decay $J/\psi \to \gamma \phi \phi \to \gamma K^+ K^- K^0_S K^0_L$ is studied. The $\phi\phi$ invariant mass distribution exhibits a near-threshold enhancement that peaks around 2.24 GeV/$c^{2}$. A partial wave analysis shows that the structure is dominated by a $0^{-+}$ state ($\eta(2225)$) with a mass of $2.24^{+0.03}_{-0.02}{}^{+0.03}_{-0.02}$ GeV/$c^{2}$ and a width of $0.19 \pm 0.03^{+0.06}_{-0.04}$ GeV/$c^{2}$. The product branching fraction is: $Br(J/\psi \to \gamma \eta(2225))\cdot Br(\eta(2225)\to \phi\phi) = (4.4 \pm 0.4 \pm 0.8)\times 10^{-4}$.Comment: 11 pages, 4 figures. corrected proof for journa

Direct Measurements of Absolute Branching Fractions for D0 and D+ Inclusive Semimuonic Decays

By analyzing about 33 $\rm pb^{-1}$ data sample collected at and around 3.773 GeV with the BES-II detector at the BEPC collider, we directly measure the branching fractions for the neutral and charged $D$ inclusive semimuonic decays to be $BF(D^0 \to \mu^+ X) =(6.8\pm 1.5\pm 0.7)$ and $BF(D^+ \to \mu^+ X) =(17.6 \pm 2.7 \pm 1.8)$, and determine the ratio of the two branching fractions to be $\frac{BF(D^+ \to \mu^+ X)}{BF(D^0 \to \mu^+ X)}=2.59\pm 0.70 \pm 0.25$