Exact Solutions of Model Hamiltonian Problems with Effective Interactions

We demonstrate with soluble models how to employ the effective Hamiltonian approach of Lee and Suzuki to obtain all the exact eigenvalues of the full Hamiltonian. We propose a new iteration scheme to obtain the effective Hamiltonian and demonstrate its convergence properties.Comment: 12 pages and 1 figur

Interaction between graphene and SiO2 surface

With first-principles DFT calculations, the interaction between graphene and SiO2 surface has been analyzed by constructing the different configurations based on {\alpha}-quartz and cristobalite structures. The single layer graphene can stay stably on SiO2 surface is explained based on the general consideration of configuration structures of SiO2 surface. It is also found that the oxygen defect in SiO2 surface can shift the Fermi level of graphene down which opens out the mechanism of hole-doping effect of graphene absorbed on SiO2 surface observed in experiments.Comment: 17 pages, 7 figure

Minimizing Effective Many-Body Interactions

A simple two-level model is developed and used to test the properties of effective interactions for performing nuclear structure calculations in truncated model spaces. It is shown that the effective many-body interactions sensitively depend on the choice of the single-particle basis and they appear to be minimized when a self- consistent Hartree-Fock basis is used.Comment: (15 pages of text and 1 postscript figure (Figure available upon request), Preprint Number not assigned ye

Simple approximation for the starting-energy-independent two-body effective interaction with applications to 6Li

We apply the Lee-Suzuki iteration method to calculate the linked-folded diagram series for a new Nijmegen local NN potential. We obtain an exact starting-energy-independent effective two-body interaction for a multi-shell, no-core, harmonic-oscillator model space. It is found that the resulting effective-interaction matrix elements can be well approximated by the Brueckner G-matrix elements evaluated at starting energies selected in a simple way. These starting energies are closely related to the energies of the initial two-particle states in the ladder diagrams. The ``exact'' and approximate effective interactions are used to calculate the energy spectrum of 6Li in order to test the utility of the approximate form.Comment: 15 text pages and 2 PostScript figures (available upon request). University of Arizona preprint, Number unassigne

Identification and characterization of dysregulated P-element induced wimpy testis-interacting RNAs in head and neck squamous cell carcinoma.

It is clear that alcohol consumption is a major risk factor in the pathogenesis of head and neck squamous cell carcinoma (HNSCC); however, the molecular mechanism underlying the pathogenesis of alcohol-associated HNSCC remains poorly understood. The aim of the present study was to identify and characterize P-element-induced wimpy testis (PIWI)-interacting RNAs (piRNAs) and PIWI proteins dysregulated in alcohol-associated HNSCC to elucidate their function in the development of this cancer. Using next generation RNA-sequencing (RNA-seq) data obtained from 40 HNSCC patients, the piRNA and PIWI protein expression of HNSCC samples was compared between alcohol drinkers and non-drinkers. A separate piRNA expression RNA-seq analysis of 18 non-smoker HNSCC patients was also conducted. To verify piRNA expression, reverse transcription-quantitative polymerase chain reaction (RT-qPCR) was performed on the most differentially expressed alcohol-associated piRNAs in ethanol and acetaldehyde-treated normal oral keratinocytes. The correlation between piRNA expression and patient survival was analyzed using Kaplan-Meier estimators and multivariate Cox proportional hazard models. A comparison between alcohol drinking and non-drinking HNSCC patients demonstrated that a panel of 3,223 piRNA transcripts were consistently detected and differentially expressed. RNA-seq analysis and in vitro RT-qPCR verification revealed that 4 of these piRNAs, piR-35373, piR-266308, piR-58510 and piR-38034, were significantly dysregulated between drinking and non-drinking cohorts. Of these four piRNAs, low expression of piR-58510 and piR-35373 significantly correlated with improved patient survival. Furthermore, human PIWI-like protein 4 was consistently upregulated in ethanol and acetaldehyde-treated normal oral keratinocytes. These results demonstrate that alcohol consumption may cause dysregulation of piRNA expression in HNSCC and in vitro verifications identified 4 piRNAs that may be involved in the pathogenesis of alcohol-associated HNSCC

Convergence properties of the effective interaction

The convergence properties of two perturbative schemes to sum the so-called folded diagrams are critically reviewed, with an emphasis on the intruder state problem. The methods we study are the approaches of Kuo and co-workers and Lee and Suzuki. The suitability of the two schemes for shell-model calculations are discussed.Comment: 10 pages in revtex ver. 3.0. 3 figs can be obtained upon request. Univerisity of Oslo report UiO/PHYS/93-2

Probabilistic Value Selection for Space Efficient Model

An alternative to current mainstream preprocessing methods is proposed: Value Selection (VS). Unlike the existing methods such as feature selection that removes features and instance selection that eliminates instances, value selection eliminates the values (with respect to each feature) in the dataset with two purposes: reducing the model size and preserving its accuracy. Two probabilistic methods based on information theory's metric are proposed: PVS and P + VS. Extensive experiments on the benchmark datasets with various sizes are elaborated. Those results are compared with the existing preprocessing methods such as feature selection, feature transformation, and instance selection methods. Experiment results show that value selection can achieve the balance between accuracy and model size reduction.Comment: Accepted in the 21st IEEE International Conference on Mobile Data Management (July 2020

Alcohol-dysregulated miR-30a and miR-934 in head and neck squamous cell carcinoma.

BackgroundAlcohol consumption is a well-established risk factor for head and neck squamous cell carcinoma (HNSCC); however, the molecular mechanisms by which alcohol promotes HNSCC pathogenesis and progression remain poorly understood. Our study sought to identify microRNAs that are dysregulated in alcohol-associated HNSCC and investigate their contribution to the malignant phenotype.MethodUsing RNA-sequencing data from 136 HNSCC patients, we compared the expression levels of 1,046 microRNAs between drinking and non-drinking cohorts. Dysregulated microRNAs were verified by qRT-PCR in normal oral keratinocytes treated with biologically relevant doses of ethanol and acetaldehyde. The most promising microRNA candidates were investigated for their effects on cellular proliferation and invasion, sensitivity to cisplatin, and expression of cancer stem cell genes. Finally, putative target genes were identified and evaluated in vitro to further establish roles for these miRNAs in alcohol-associated HNSCC.ResultsFrom RNA-sequencing analysis we identified 8 miRNAs to be significantly upregulated in alcohol-associated HNSCCs. qRT-PCR experiments determined that among these candidates, miR-30a and miR-934 were the most highly upregulated in vitro by alcohol and acetaldehyde. Overexpression of miR-30a and miR-934 in normal and HNSCC cell lines produced up to a 2-fold increase in cellular proliferation, as well as induction of the anti-apoptotic gene BCL-2. Upon inhibition of these miRNAs, HNSCC cell lines exhibited increased sensitivity to cisplatin and reduced matrigel invasion. miRNA knockdown also indicated direct targeting of several tumor suppressor genes by miR-30a and miR-934.ConclusionsAlcohol induces the dysregulation of miR-30a and miR-934, which may play crucial roles in HNSCC pathogenesis and progression. Future investigation of the alcohol-mediated pathways effecting these transformations will prove valuable for furthering the understanding and treatment of alcohol-associated HNSCC