Selenium nanoparticles decorated with Ulva lactuca polysaccharide potentially attenuate colitis by inhibiting NF-κB mediated hyper inflammation

Additional file 1. Supplemental information of ULP-SeNPs concerns their stability in physiological solutions, uptake by BMDMs and effect on NF-κB activation

Genome sequence of the insect pathogenic fungus Cordyceps militaris, a valued traditional chinese medicine

Species in the ascomycete fungal genus Cordyceps have been proposed to be the teleomorphs of Metarhizium species. The latter have been widely used as insect biocontrol agents. Cordyceps species are highly prized for use in traditional Chinese medicines, but the genes responsible for biosynthesis of bioactive components, insect pathogenicity and the control of sexuality and fruiting have not been determined. Here, we report the genome sequence of the type species Cordyceps militaris. Phylogenomic analysis suggests that different species in the Cordyceps/Metarhizium genera have evolved into insect pathogens independently of each other, and that their similar large secretomes and gene family expansions are due to convergent evolution. However, relative to other fungi, including Metarhizium spp., many protein families are reduced in C. militaris, which suggests a more restricted ecology. Consistent with its long track record of safe usage as a medicine, the Cordyceps genome does not contain genes for known human mycotoxins. We establish that C. militaris is sexually heterothallic but, very unusually, fruiting can occur without an opposite mating-type partner. Transcriptional profiling indicates that fruiting involves induction of the Zn2Cys6-type transcription factors and MAPK pathway; unlike other fungi, however, the PKA pathway is not activated.https://doi.org/10.1186/gb-2011-12-11-r11

Sex Differences in Abnormal Intrinsic Functional Connectivity After Acute Mild Traumatic Brain Injury

Mild traumatic brain injury (TBI) is considered to induce abnormal intrinsic functional connectivity within resting-state networks (RSNs). The objective of this study was to estimate the role of sex in intrinsic functional connectivity after acute mild TBI. We recruited a cohort of 54 patients (27 males and 27 females with mild TBI within 7 days post-injury) from the emergency department (ED) and 34 age-, education-matched healthy controls (HCs; 17 males and 17 females). On the clinical scales, there were no statistically significant differences between males and females in either control group or mild TBI group. To detect whether there was abnormal sex difference on functional connectivity in RSNs, we performed independent component analysis (ICA) and a dual regression approach to investigate the between-subject voxel-wise comparisons of functional connectivity within seven selected RSNs. Compared to female patients, male patients showed increased intrinsic functional connectivity in motor network, ventral stream network, executive function network, cerebellum network and decreased connectivity in visual network. Further analysis demonstrated a positive correlation between the functional connectivity in executive function network and insomnia severity index (ISI) scores in male patients (r = 0.515, P = 0.006). The abnormality of the functional connectivity of RSNs in acute mild TBI showed the possibility of brain recombination after trauma, mainly concerning male-specific

Temporal variability of visibility and its parameterizations in Ningbo, China

Simultaneous and continuous measurements of visibility, meteorological parameters and air pollutants were carried out at a suburban site in Ningbo from June 1, 2013 to May 31, 2015. The characteristics of visibility and their relationships with air pollutants and meteorological factors were investigated using multiple statistical methods. Daily visibility ranged from 0.6 to 34.1 km, with a mean value of 11.8 km. During the 2-year experiment, 43.4% of daily visibility was found to be less than 10.0 km and only 9.2% was greater than 20.0 km. Visibility was lower in winter with a frequency of 53.4% in the range of 0.0–5.0 km. Annual visibility had an obvious diurnal variation, with the lowest and highest visibility being 7.5 km at approximately 06:00 local time and 15.6 km at approximately 14:00 local time, respectively. Multiple correspondence analysis (MCA) indicated that the different ranges of visibility were significantly affected by different levels of pollutants and meteorological conditions. Based on the analyses, visibility was found to be an exponential function of PM2.5 concentrations within a certain range of relative humidity. Thus, non-linear models combining multiple linear regressions with exponential regression were subsequently developed using the data collected from June 2014 to May 2015, and the data from June 2013 to May 2014 was used to evaluate the performance of the model. It was demonstrated that the derived models can quantitatively describe the relationships between visibility, air quality and meteorological parameters in Ningbo

(A)Study on relationships between space and object based on color theory : focused on contrast and harmony

학위논문(석사)--서울대학교 대학원 :디자인학부 공업디자인전공,2005.Maste

Probabilistic calibration of stress-strain models for confined high-strength concrete

A comprehensive probabilistic calibration of traditional deterministic models for peak stress, peak strain, and stress-strain curves of confined high-strength concrete (HSC) was investigated. The probabilistic models for peak stress and peak strain of confined HSC were first established by combining the Markov chain Monte Carlo (MCMC) method with the Bayesian theory. A probabilistic stress-strain model of confined HSC was then proposed to provide a probabilistic approach to calibrate the confidence level and computational accuracy of four typical deterministic stress-strain models of confined HSC. Analysis results show that the randomness of the stress-strain curve in the ascending branch is not obvious, but that in the descending branch after peak stress is significant. Deterministic stress-strain models can better predict tested stress-strain curves in ascending branches with a greater confidence level than descending branches. The tested stress-strain curves generally fall within the 50% confidence interval of the probabilistic stress-strain model, which implies that the proposed probabilistic stress-strain models can adequately describe the probabilistic characteristic of stress-strain curves of confined HSC

Analysis on spatial-temporal distribution characteristics of smear positive pulmonary tuberculosis in China, 2004–2015

Background: In China, tuberculosis (TB) is still a major infectious disease threatening people’s health. Smear positive pulmonary TB is one of the most common infectious forms of TB and it might easily cause the outbreak in some areas. With a better understanding of the spatial-temporal variations of smear positive PTB, we would reach the targets for TB prevention and controlling, identify high-risk areas and periods. Thus, the aim of this study was to investigate the spatial-temporal variations of smear positive PTB. Methods: Provincial level data of reported smear positive PTB monthly cases and incidence from January 2004 to December 2015 were obtained from the National Scientific Data Sharing Platform for Population and Health of China. Purely spatial-temporal descriptive analysis was used to characterize the distribution patterns of smear positive PTB. The global spatial auto-correlation statistics (Moran’s I) and the local indicators of spatial association (LISA) were conducted to identify the spatial auto-correlation and high risk areas of smear positive PTB cases. Furthermore, the space-time scan statistic was adopted to detect the spatial-temporal clusters in different periods. Results: A total of 4,711,571 smear positive PTB cases were notified in China with an average annual incidence of 29.59/100,000. The proportion of male in different age groups were obviously higher than that of women. The largest number of cases was reported in the 20–24 years age group. Time-series analysis indicated that monthly incidence appeared a clearly seasonality and periodicity, which the seasonal peaks occurred in January and March. Smear positive PTB cases had a positive global spatial auto-correlation in 2013–2015 (Moran‘s I = 0.186, P = 0.046). Spatial clusters were identified in four periods, located in the different regions. The time period of 2004–2006, the most likely spatial-temporal cluster (RR = 1.69, P < 0.001) was mainly located in Hubei, Hunan, Jiangxi and Anhui of central China, clustering in the time frame from January 2005 to June 2006. During 2007–2009, the most likely spatial-temporal cluster (RR = 5.65, P < 0.001) was located in Guizhou, clustering in the time frame from January to December 2009. The spatial-temporal clustering in the years 2010–2012 showed the most likely cluster (RR = 1.44, P < 0.001) was distributed in Anhui, Hunan, Hubei, Jiangxi and Guangdong with the time frame from January 2010 to June 2011. During 2013–2015, the most likely cluster (RR = 1.86, P < 0.001) was detected in Hunan, Hubei, Jiangxi and Guangdong from February 2013 to June 2014. Conclusions: This study identified the spatial-temporal patterns of smear positive PTB in China and demonstrated the capability and utility of the spatial-temporal approach in epidemiology. The results of this study would contribute to estimating the high risk periods and areas, and to providing more useful information for policy-making. Keywords: Smear positive PTB, Spatial auto-correlation, Spatial-temporal scannin