414 research outputs found
Probing dark particles indirectly at the CEPC
When dark matter candidate and its parent particles are nearly degenerate, it
would be difficult to probe them at the Large Hadron Collider directly. We
propose to explore their quantum loop effects at the CEPC through the golden
channel process . We use a renormalizable toy model
consisting of a new scalar and a fermion to describe new physics beyond the
Standard Model. The new scalar and fermion are general multiplets of the
symmetry, and couple to the muon lepton through Yukawa
interaction. We calculate their loop contributions to anomalous
and couplings which can be applied to many new
physics models. The prospects of their effects at the CEPC are also examined
assuming a 0.002 accuracy in the cross section measurement
Topological Zero-Thickness Cosmic Strings
In this paper, based on the gauge potential decomposition and the
mapping theories, we study the topological structures and properties of
the cosmic strings that arise in the Abelian-Higgs gauge theory in the
zero-thickness limit. After a detailed discussion, we conclude that the
topological tensor current introduced in our model is a better and more basic
starting point than the generally used Nambu-Goto effective action for studying
cosmic strings.Comment: 10 pages, no figure
1H-Imidazol-3-ium-4-carboxylate
In the title compound, C4H4N2O2, both imidazole N atoms are protonated and carboxylate group is deprotonated, resulting in a zwitterion. The molecule is essentially planar, with an r.m.s. deviation of 0.012 (1) Å. In the crystal, N—H⋯O hydrogen bonds and π–π stacking interactions [centroid–centroid distance = 3.674 (2) Å] between the imidazole rings link the molecules into a three-dimensional supramolecular network
Fermion Absorption Cross Section and Topology of Spherically Symmetric Black Holes
In 1997, Liberati and Pollifrone in Phys. Rev. D56 (1997) 6458
(hep-th/9708014) achieved a new formulation of the Bekenstein-Hawking formula,
where the entropy and the Euler characteristic are related by . In
this work we present a relation between the low-energy absorption cross section
for minimally coupled fermions and the Euler characteristic of
(3+1)-dimensional spherically symmetric black holes, i.e. . Based on the relation, using the Gauss--Bonnet--Chern theorem and
the -mapping method, an absorption cross section density is introduced to
describe the topology of the absorption cross section. It is shown that the
absorption cross section and its density are determined by the singularities of
the timelike Killing vector field of the spacetime and these singularities
carry the topological numbers, Hopf indices and Brouwer degrees, naturally.Comment: 16 pages, no figures, accepted by Phys. Lett.
High expression of transcriptional coactivator p300 correlates with aggressive features and poor prognosis of hepatocellular carcinoma
<p>Abstract</p> <p>Background</p> <p>It has been suggested that p300 participates in the regulation of a wide range of cell biological processes and mutation of p300 has been identified in certain types of human cancers. However, the expression dynamics of p300 in hepatocellular carcinoma (HCC) and its clinical/prognostic significance are unclear.</p> <p>Methods</p> <p>In this study, the methods of reverse transcription-polymerase chain reaction (RT-PCR), Western blotting and immunohistochemistry (IHC) were utilized to investigate protein/mRNA expression of p300 in HCCs. Receiver operating characteristic (ROC) curve analysis, spearman's rank correlation, Kaplan-Meier plots and Cox proportional hazards regression model were used to analyze the data.</p> <p>Results</p> <p>Up-regulated expression of p300 mRNA and protein was observed in the majority of HCCs by RT-PCR and Western blotting, when compared with their adjacent non-malignant liver tissues. According to the ROC curves, the cutoff score for p300 high expression was defined when more than 60% of the tumor cells were positively stained. High expression of p300 was examined in 60/123 (48.8%) of HCCs and in 8/123 (6.5%) of adjacent non-malignant liver tissues. High expression of p300 was correlated with higher AFP level, larger tumor size, multiplicity, poorer differentiation and later stage (<it>P </it>< 0.05). In univariate survival analysis, a significant association between overexpression of p300 and shortened patients' survival was found (<it>P </it>= 0.001). In different subsets of HCC patients, p300 expression was also a prognostic indicator in patients with stage II (<it>P </it>= 0.007) and stage III (<it>P </it>= 0.011). Importantly, p300 expression was evaluated as an independent prognostic factor in multivariate analysis (<it>P </it>= 0.021). Consequently, a new clinicopathologic prognostic model with three poor prognostic factors (p300 expression, AFP level and vascular invasion) was constructed. The model could significantly stratify risk (low, intermediate and high) for overall survival (<it>P </it>< 0.0001).</p> <p>Conclusions</p> <p>Our findings provide a basis for the concept that high expression of p300 in HCC may be important in the acquisition of an aggressive phenotype, suggesting that p300 overexpression, as examined by IHC, is an independent biomarker for poor prognosis of patients with HCC. The combined clinicopathologic prognostic model may become a useful tool for identifying HCC patients with different clinical outcomes.</p
Geometry and optics calibration of WFCTA prototype telescopes using star light
The Large High Altitude Air Shower Observatory project is proposed to study
high energy gamma ray astronomy ( 40 GeV-1 PeV ) and cosmic ray physics ( 20
TeV-1 EeV ). The wide field of view Cherenkov telescope array, as a component
of the LHAASO project, will be used to study energy spectrum and compositions
of cosmic ray by measuring the total Cherenkov light generated by air showers
and shower maximum depth. Two prototype telescopes have been in operation since
2008. The pointing accuracy of each telescope is crucial to the direction
reconstruction of the primary particles. On the other hand the primary energy
reconstruction relies on the shape of the Cherenkov image on the camera and the
unrecorded photons due to the imperfect connections between photomultiplier
tubes. UV bright stars are used as point-like objects to calibrate the pointing
and to study the optical properties of the camera, the spot size and the
fractions of unrecorded photons in the insensitive areas of the camera.Comment: 5 pages, 6 figures, submitted to Chinese Physics
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