Evaporation Features of Water Droplets with Typical Subsoil Impurities During the Motion Through High-Temperature Gas Environment: Research Experience at Tomsk Polytechnic University

This paper investigates experimentally the evaporation rate of water droplets with typical subsoil impurities (clay, silt, soil, sand) during the motion through high-temperature gas environment. The experiments were conducted at Tomsk Polytechnic University using high-speed video recording and modern video processing methods. Here, we analyze the influence of the impurity concentration on the intensity of heating and phase changes. The present study defines, how the preheating of impurities affects the completeness of the evaporation of water droplets with impurities. As a result, of studies, we draw the conclusion that it is possible to use water from natural reservoirs without prior preparation for wildfires extinguishing

Peculiarities of Investment Decision-making in the Oil and Gas Industry Aimed to Ensure Sustainable Growth of the Russian Economy

A dynamic analysis of the composition and structure of the oil and gas sector of the Russian economy was carried out in the study, a relationship between cyclical fluctuations of the world economy and energy prices was analyzed, and trends in world market prices for energy were studied. The authors identified basic systematic risks and uncertainties affecting investment decision-making in the Russian oil and gas sector and studied the peculiarities of making investment decisions. The academic novelty of the study is to propose specific ways to improve the investment decision-making of the Russian oil and gas business entities in the context of high macroeconomic risks to ensure sustainable growth of the Russian economy. The results obtained in the framework of the present study may be implemented by enterprises of the oil and gas industry and will also be of interest to other business structures in risk management, which is especially relevant in the context of high economic and geopolitical uncertainty. The paper presents mathematical models and justifies the choice of parameters to evaluate the fields taking the uncertainty into account. The approaches to formation of the investment decision-making policy based on real options method are proposed. Keywords: oil and gas sector, oil and gas investment projects, oil quotations, decision-making models, real options JEL Classifications: E3, Q

ОБЩЕЕ СОБРАНИЕ ВЛАДЕЛЬЦЕВ ИНВЕСТИЦИОННЫХ ПАЕВ: ОРГАНИЗАЦИОННЫЕ АСПЕКТЫ

General meeting of owners of the investment shares, possessing large powersof strategic character, needs continuous development of the substantial and organizational parties, with the subsequent entering of corresponding changes into acts.In article some organizational aspects ofcarrying out general meeting and possibility of their improvement are considered.Общее собрание владельцев инвестиционных паев, обладающее широкими полномочиями стратегического характера, нуждаетсявпостоянномразвитии содержательной и организационной сторон, с последующим внесением соответствующих изменений в законодательныеакты. Встатьерассмотрены некоторые организационные аспекты проведенияобщегособранияивозможности их совершенствования

Russian-Chinese Cooperation Prospects in the Electric Power Industry

Russia and China have long been trading partners and cooperated in most industries, including the electric power sector. Even with close and long-standing ties, the further scope of Russian-Chinese relations in the electric power sector should be defined taking into account China's currently implemented Belt and Road Initiative requiring enormous resources, particularly in commodities. An analysis of Russia's electric power market shows an imbalance between the levels of demand and supply skewing to the supply side. Russian excess supply of electricity could be feasibly channelled to China under long-term contracts. For now, such supplies have not been operated at the levels planned several years ago, which indicates low utilisation of the existing potential of cooperation between the countries in the sector. Besides, considerable potential exists for partnership between Russia and China in upgrading electric power facilities and supplying electricity equipment and its subsequent maintenance

ON THE ISSUE OF CHANGING THE MORPHOLOGY OF THE SPLEEN IN NEMATODOSES IN MICE DURING IMMUNOSTIMULATION

Background. The study of the reaction of the immune system organs to the introduction of immunomodulators in nematodes is relevant for the development of treatment regimens. The purpose of the study was to examine the spleen (the organ of immunogenesis that plays an important role in the formation of immunity). In addition, the aim of the study was also to find the morphological changes of nematodes (capsules of trichinella larvae) and the features of siphatiа. Materials and methods. In the experiment, 35 white mice were used, which were divided into 5 groups of 7 animals in each group. The first and second groups were injected with 0.004 mg saline solution subcutaneously, the 3rd and 4th groups were injected with polyoxidonium at a dose of 0.004 mg/mouse, the 1st and 3rd groups were infected with trichinella larvae, the 2nd and 4th were spontaneously affected by syphilis, the 5th group served as control. Evaluation of the protective properties of polyoxidonium in laboratory models with trichinosis was carried out by determining the intensity of invasion during postmortem studies of all muscle groups of the animal and siphations by the number of eggs in perianal scrapings. Results. The study showed protective efficacy with the introduction of polyoxidonium was 99.43%, 57 ± 20 trichinella larvae / per animal were detected in the entire muscle mass, while only 72% with syphaciosis. The parenchyma of the organ of the spleen is a red-white pulp, in healthy animals the area of the red pulp was 70+5% of the area of the organ, and the white pulp was 26.5+ 5% of the mass of the organ. In animals infected with nematodes, the area of the white pulp increased dramatically to 50% of the organ area or more. Conclusion. Significant protective activity of polyoxidonium (99.43%) was established in parasitological studies, which was accompanied by an increase in the area of lymphoid tissue associated with the intestine. When studying histological preparations of the spleen, it was noted that the restructuring of the structure under the action of trichinella and siphacia antigens is of the same type: the ratio of red and white pulp, their cellular composition changes. It was found that in all infected animals, the area of the white pulp increased dramatically by more than 60% with trichinosis and up to 50% with syphacosis of the organ area or more. The final result of this thesis was using polyoxidonium, there was also a decrease in the number of eggs in the control group and changes in the number and actual distribution of trichinella larvae in various muscle groups

The Formation of Indicator Framework for Effective Assessment of Investment Attractiveness of the Region

Despite the in-depth study of many theoretical aspects of investment activities and assessment of investment attractiveness, today the impact of the investment policy on the development of an effective strategy and the formation of favorable investment climate is not properly reflected in the contemporary research. At the same time unstable situation in socio-economic development of Russia requires new approaches to the problem of investment activity. In this regard, the article provides indicator framework to assess properly the investment attractiveness of the region's economy relating to foreign direct investment in the current context. At that, the proposed indicator framework is based on a number of principles, which allow achieving the objective assessment of investment attractiveness of regions and feasibility of the concerned indicators. Keywords: foreign direct investment, investment activity, investment climate, assessment of investment attractiveness, region's economy. JEL Classifications: F21; F51; H77; O2

Use of Azospirillum baldaniorum cells in quercetin detection

The possibility of detection and determination of flavonoids by using microbial cells was shown for the first time using the quercetin - Azospirillum baldaniorum Sp245 model system. The activity of the flavonoids quercetin, rutin and naringenin toward A. baldaniorum Sp245 was evaluated. It was found that when the quercetin concentration ranged from 50 to 100 µM, the number of bacterial cells decreased. Rutin and naringenin did not affect bacterial numbers. Quercetin at 100 μM increased bacterial impedance by 60 %. Under the effect of quercetin, the magnitude of the electro-optical signal from cells decreased by 75 %, as compared with the no-quercetin control. Our data show the possibility of developing sensor-based systems for the detection and determination of flavonoids

Design of the Nephrotic Syndrome Study Network (NEPTUNE) to evaluate primary glomerular nephropathy by a multidisciplinary approach

The Nephrotic Syndrome Study Network (NEPTUNE) is a North American multi-center collaborative consortium established to develop a translational research infrastructure for Nephrotic Syndrome. This includes a longitudinal observational cohort study, a pilot and ancillary studies program, a training program, and a patient contact registry. NEPTUNE will enroll 450 adults and children with minimal change disease, focal segmental glomerulosclerosis and membranous nephropathy for detailed clinical, histopathologic, and molecular phenotyping at the time of clinically-indicated renal biopsy. Initial visits will include an extensive clinical history, physical examination, collection of urine, blood and renal tissue samples, and assessments of quality of life and patient-reported outcomes. Follow-up history, physical measures, urine and blood samples, and questionnaires will be obtained every 4 months in the first year and bi-annually, thereafter. Molecular profiles and gene expression data will be linked to phenotypic, genetic, and digitalized histologic data for comprehensive analyses using systems biology approaches. Analytical strategies were designed to transform descriptive information to mechanistic disease classification for Nephrotic Syndrome and to identify clinical, histological, and genomic disease predictors. Thus, understanding the complexity of the disease pathogenesis will guide further investigation for targeted therapeutic strategies

Design and baseline characteristics of the finerenone in reducing cardiovascular mortality and morbidity in diabetic kidney disease trial

Background: Among people with diabetes, those with kidney disease have exceptionally high rates of cardiovascular (CV) morbidity and mortality and progression of their underlying kidney disease. Finerenone is a novel, nonsteroidal, selective mineralocorticoid receptor antagonist that has shown to reduce albuminuria in type 2 diabetes (T2D) patients with chronic kidney disease (CKD) while revealing only a low risk of hyperkalemia. However, the effect of finerenone on CV and renal outcomes has not yet been investigated in long-term trials. Patients and Methods: The Finerenone in Reducing CV Mortality and Morbidity in Diabetic Kidney Disease (FIGARO-DKD) trial aims to assess the efficacy and safety of finerenone compared to placebo at reducing clinically important CV and renal outcomes in T2D patients with CKD. FIGARO-DKD is a randomized, double-blind, placebo-controlled, parallel-group, event-driven trial running in 47 countries with an expected duration of approximately 6 years. FIGARO-DKD randomized 7,437 patients with an estimated glomerular filtration rate >= 25 mL/min/1.73 m(2) and albuminuria (urinary albumin-to-creatinine ratio >= 30 to <= 5,000 mg/g). The study has at least 90% power to detect a 20% reduction in the risk of the primary outcome (overall two-sided significance level alpha = 0.05), the composite of time to first occurrence of CV death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for heart failure. Conclusions: FIGARO-DKD will determine whether an optimally treated cohort of T2D patients with CKD at high risk of CV and renal events will experience cardiorenal benefits with the addition of finerenone to their treatment regimen. Trial Registration: EudraCT number: 2015-000950-39; ClinicalTrials.gov identifier: NCT02545049

THE POSSIBILITY OF APPLICATION OF CRYSTALLOGRAPHY TECHNIQUES IN THE STUDYING OF LEISHMANIASIS

Leishmaniosis is diagnosed usually by direct visualization of the amastigotes in hosts’ tissues. However, the retrieval of tissue samples is often painful for the patient and identification of the infected cells can be difficult, especially when scanty parasites occur in the examined tissue. Several animals’ species of carnivores were studied. In the search of an alternative diagnostic tool, the bioliquids (sera, urine, saliva) of canids (dogs, red and polar foxes and raccoon dogs) screened by serology, were studied by coproscopy and crystalloscopy (classic and tezigraphy), also. This study also represents the first epizootological study of biosubstrats of dogs in the South of RF, and epidemiological analysis of cases of Leishmaniasis in RF.The development of hunting and tourism, on the one hand, and the increase in the number of domestic carnivores, on the other hand, has lead to the mutual circulation of pathogens between natural and synanthropic foci and, as a result, to an increase in human infections with leishmaniasis pathogens. In this regard, the search for more effective measures of the invasion control is becoming on the agenda. Undoubtedly, the material well-being of the population, demographic and cultural characteristics have a significant impact on the spread of leishmaniasis. At the same time, highly effective, accurate and quick diagnosis of this parasitosis in animals, the organization of veterinary and health measures should be aimed at reliable prevention of anthropozoonosis in the population