Laws for River Training Projects

Source: ICHE Conference Archive - https://mdi-de.baw.de/icheArchiv

River Network Patterns and Their Evolutionary Preconditions

Source: ICHE Conference Archive - https://mdi-de.baw.de/icheArchiv

Properties of Positive Solution for Nonlocal Reaction-Diffusion Equation with Nonlocal Boundary

This paper considers the properties of positive solutions for a nonlocal equation with nonlocal boundary condition u(x,t)=∫Ωf(x,y)u(y,t)dy on ∂Ω×(0,T). The conditions on the existence and nonexistence of global positive solutions are given. Moreover, we establish the uniform blow-up estimates for the blow-up solution

Experimental Study on Landslides of Loose Sediment Slope Induced by Stream Bed Incision

Uplift of the Qinghai-Tibetan Plateau has resulted in rapid incision of rivers along the margin of the plateau. Landslides occur frequently as a consequence of increasing bank slope and potential landslide energy due to stream bed incision or lateral bank erosion on the concave banks at bends. The Fencha Gully is on the eastern margin of the Qinghai-Tibetan Plateau and is developing on a huge landslide body. Flume experiments were conducted on the base of the field investigation to study the mechanism of landslides induced by stream bed incision. The experiments were designed with a length scale ratio of 1:20. Landslides and stream bed incision with loose sediment were observed and analyzed. The results show that landslides are induced as a result of stream bed incision. The potential landslide energy is defined, which increases quickly with an effective incision depth coupling vertical incision and lateral bank erosion. The occurrence of landslides can be attributed to increasing incision depth and potential landslide energy. Results indicate that the critical effective incision depth is 4.0–6.0 m. A critical value of the potential landslide energy is found from the experiments. Landslides occur if the potential energy exceeds the critical energy, which is 2.24×104 t·m/s2 for the Fencha Gully. The incision depth and potential energy of landslides from the Fencha Gully agree well with the results

Experimental study on control of Limnoperna fortunei biofouling in water transfer tunnels

The golden mussel (Limnoperna fortunei) is a filter-collector macroinvertebrate species originating from southern China. It easily invades water transfer tunnels and attaches onto tunnel walls and structures with extremely high density, resulting in biofouling, pipe clogging, structure corrosion, a decrease in water transfer efficiency, and water pollution. It has become a prevalent problem and has caused concern all over the world. However, an effective and environment friendly method of controlling golden mussel invasion has not yet been approved. This study is aimed to propose measures for preventing golden mussel invasion and biofouling in the water transfer tunnels of the East River Water Source Project (ERWSP), which transfers water from the East River to Shenzhen, southern China for 10 million people. Long-term samplings and observations of the East River water were performed to study the golden mussel's invading pattern. Flume experiments were done to study the golden mussel's attachment on 14 different materials and performance in turbulent flows. An integrated ecological prevention pool was designed and constructed based on the flume experimental results for preventing the golden mussel invasion in the scale model tunnels of the ERWSP. The major technology of the ecological pool was preventing the golden mussel from entering the tunnels by attracting veligers to attach on geotextile cloth, attracting mussels to attach on bamboo, and killing veligers with high-frequency turbulence. An eight-month application experiment showed that the ecological pool successfully controlled the golden mussel invasion and biofouling in the scale model tunnels. The mussel density on the attachment materials decreased sharply as the distance of the materials from the pool entrance increased; the turbulence was effective in killing veligers that escaped from the attachment materials. No mussel was found on the model tunnels. Thus, the integrated ecological prevention pool is recommended as a successful measure for controlling the golden mussel invasion and biofouling in water transfer tunnels.Facultad de Ciencias Naturales y Muse

Serum metabolites and hypercholesterolemia: insights from a two-sample Mendelian randomization study

BackgroundHypercholesterolemia, a critical contributor to cardiovascular disease, is not fully understood in terms of its relationship with serum metabolites and their role in disease pathogenesis.MethodsThis study leveraged GWAS data to explore the relationship between serum metabolites and hypercholesterolemia, pinpointing significant metabolites via Mendelian Randomization (MR) and KEGG pathway enrichment analysis. Data on metabolites were sourced from a European population, with analysis focusing on individuals diagnosed with hypercholesterolemia.ResultsOut of 486 metabolites analyzed, ten showed significant associations with hypercholesterolemia, categorized into those enhancing risk and those with protective effects. Specifically, 2-methoxyacetaminophen sulfate and 1-oleoylglycerol (1-monoolein) were identified as risk-enhancing, with odds ratios (OR) of 1.545 (95% CI: 1.230–1.939; P_FDR = 3E−04) and 1.462 (95% CI: 1.036–2.063; P_FDR = 0.037), respectively. On the protective side, 3-(cystein-S-yl)acetaminophen, hydroquinone sulfate, and 2-hydroxyacetaminophen sulfate demonstrated ORs of 0.793 (95% CI: 0.735–0.856; P_FDR = 6.18E−09), 0.641 (95% CI: 0.423–0.971; P_FDR = 0.042), and 0.607 (95% CI: 0.541–0.681; P_FDR = 5.39E−17), respectively. In addition, KEGG pathway enrichment analysis further revealed eight critical pathways, comprising “biosynthesis of valine, leucine, and isoleucine”, “phenylalanine metabolism”, and “pyruvate metabolism”, emphasizing their significant role in the pathogenesis of hypercholesterolemia.ConclusionThis study underscores the potential causal links between particular serum metabolites and hypercholesterolemia, offering innovative viewpoints on the metabolic basis of the disease. The identified metabolites and pathways offer promising targets for therapeutic intervention and warrant further investigation

INCB84344-201: Ponatinib and steroids in frontline therapy for unfit patients with Ph+ acute lymphoblastic leukemia

Tyrosine kinase inhibitors have improved survival for patients with Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL). However, prognosis for old or unfit patients remains poor. In the INCB84344-201 (formerly GIMEMA LAL 1811) prospective, multicenter, phase 2 trial, we tested the efficacy and safety of ponatinib plus prednisone in newly diagnosed patients with Ph+ ALL 6560 years, or unfit for intensive chemotherapy and stem cell transplantation. Forty-four patients received oral ponatinib 45 mg/d for 48 weeks (core phase), with prednisone tapered to 60 mg/m2/d from days-14-29. Prophylactic intrathecal chemotherapy was administered monthly. Median age was 66.5 years (range, 26-85). The primary endpoint (complete hematologic response [CHR] at 24 weeks) was reached in 38/44 patients (86.4%); complete molecular response (CMR) in 18/44 patients (40.9%) at 24 weeks. 61.4% of patients completed the core phase. As of 24 April 2020, median event-free survival was 14.31 months (95% CI 9.30-22.31). Median overall survival and duration of CHR were not reached; median duration of CMR was 11.6 months. Most common treatment-emergent adverse events (TEAEs) were rash (36.4%), asthenia (22.7%), alanine transaminase increase (15.9%), erythema (15.9%), and \u3b3-glutamyltransferase increase (15.9%). Cardiac and vascular TEAEs occurred in 29.5% (grade 653, 18.2%) and 27.3% (grade 653, 15.9%), respectively. Dose reductions, interruptions, and discontinuations due to TEAEs occurred in 43.2%, 43.2%, and 27.3% of patients, respectively; 5 patients had fatal TEAEs. Ponatinib and prednisone showed efficacy in unfit patients with Ph+ ALL; however, a lower ponatinib dose may be more appropriate in this population. This trial was registered at www.clinicaltrials.gov as #NCT01641107

Blowup Analysis for a Semilinear Parabolic System with Nonlocal Boundary Condition

<p/> <p>This paper deals with the properties of positive solutions to a semilinear parabolic system with nonlocal boundary condition. We first give the criteria for finite time blowup or global existence, which shows the important influence of nonlocal boundary. And then we establish the precise blowup rate estimate for small weighted nonlocal boundary.</p