Influence of Cinepazide Maleate on Vascular Endothelial Function of Patients with Acute Myocardial Infarction

Objective: To study influence of cinepazide maleate on vascular endothelial function of patients with acute myocardial infarction. Methods: 150 cases of patients with acute myocardial infarction were divided into the observation group and the control group, two groups were treated by conventional therapy about acute myocardial infarction, the observation group added 5%GS250 mL + cinepazide maleate 160 mg IV drip q.d, the control group added 5%GS250 mL IV drip q.d, the treatment course were 3 weeks, changes of vascular endothelial function and the blood serum no level before and after treatment were detected. Result: vascular endothelial function after treatment in observation group were obviously improved than that before treatment (p = 0.03) , blood serum no level was obviously increased (p ﹤ 0.05); about 3 weeks after treatment, vascular endothelial function in the observation group was obviously better than that of the control group (p = 0.04), the blood serum no level of the observation group was obviously higher than that of the control group (p ﹤ 0.05). Conclusion: Cinepazide maleate remarkably improves vascular endothelial function of patients with acute myocardial infarction

Effect of YKL-40 RNA Interference on VEGF Gene Polymorphism Expression in Atherosclerotic Mice

Aims: To investigate the effect of YKL-40 RNA interference on VEGF gene polymorphism expression in atherosclerotic mice. Methods: After the atherosclerosis models in mice were built, the mice were divided into three groups including control group, negative control group and observation group, which were separately given to normal saline, negative virus (5 × 107 TU) and YKL-40 RNA interference lentivirus. Then the whole blood DNA was extracted and genotyped in each group of mice and the expression of VEGF in each group of mice was detected by PCR, while the expression level of inflammatory factors in each group of mice was detected by ELISA. Meanwhile, the aortas of mice in each group were pathologically analyzed and the atherosclerosis of mice was detected. Results: Compared with the control group, the VEGF content in both the virus negative control group and the observation group was significantly increased（P<0.05）. The detection rates of CC genotype and C allele at rs699947 of VEGF gene in the observation group were significantly higher than those in the control group and the virus negative control group, and the difference was statistically significant. There were no significant changes for the expression of HDL-C, LDL-C, TC and TG in mice of each group（P>0.05）. Moreover, the levels of Lp-PLA2 and MCP-1 in the negative control group were significantly increased (P < 0.05), while those in the observation group were significantly decreased (P < 0.05) compared to that in control group. What’s more, the histomorphology of the observation group was significantly different from that of the control group and the virus negative control group. The thickness of the fibrous cap of the as plaque was significantly higher than that of the control group and the virus negative control group, but the plaque area and fat content were significantly lower than that of the control group and the virus negative control group and the NC group. Besides, there was no significant difference in lipid content, fiber cap thickness and plaque area between the control group and the virus negative control group. Conclusion: YKL-40 RNAi could improve the VEGF polymorphism, reduce the expression of LPâƒPLA2 and MCPâƒ1, and significantly inhibit the occurrence and development of atherosclerosis, which was expected to provide a new target for the prevention and treatment of atherosclerosis

Reducing neutral-point voltage fluctuation in NPC three-level active power filters

Shunt active power filters (SAPFs) have been widely used to improve power quality of the grid by mitigating harmonics injected from nonlinear loads. This paper presents a new method for improving the performance of SAPFs using neutral-point-clamped (NPC) three-level inverters. NPC three-level inverters often suffer excessive voltage fluctuations at the neutral-point of DC-link capacitors, which may damage switching devices and cause additional high harmonic distortion of the output voltage. In order to solve the problem, two compensating schemes are proposed to restrict voltage fluctuation in the inverters. The first is voltage dependent, adopting a voltage compensation method, while the second is current dependent, using a current compensation method. The paper describes the respective circuit architectures and principles of operation. Corresponding models are mathematically formulated and evaluated under typical balanced and unbalanced working load conditions. The results show that both schemes are able to alleviate considerably voltage oscillations and hence harmonic distortions, and the current-compensated NPC inverter outperforms the voltage-compensated NPC inverter. Consequently, it is shown that the proposed approaches are effective and feasible for improving power quality of the grid when connected to nonlinear loads

Analysis of the genetic architecture of maize kernel size traits by combined linkage and association mapping

Kernel size‐related traits are the most direct traits correlating with grain yield. The genetic basis of three kernel traits of maize, kernel length (KL), kernel width (KW) and kernel thickness (KT), was investigated in an association panel and a biparental population. A total of 21 single nucleotide polymorphisms (SNPs) were detected to be most significantly (P \u3c 2.25 × 10−6) associated with these three traits in the association panel under four environments. Furthermore, 50 quantitative trait loci (QTL) controlling these traits were detected in seven environments in the intermated B73 × Mo17 (IBM) Syn10 doubled haploid (DH) population, of which eight were repetitively identified in at least three environments. Combining the two mapping populations revealed that 56 SNPs (P \u3c 1 × 10−3) fell within 18 of the QTL confidence intervals. According to the top significant SNPs, stable‐effect SNPs and the co‐localized SNPs by association analysis and linkage mapping, a total of 73 candidate genes were identified, regulating seed development. Additionally, seven miRNAs were found to situate within the linkage disequilibrium (LD) regions of the co‐localized SNPs, of which zma‐miR164e was demonstrated to cleave the mRNAs of Arabidopsis CUC1, CUC2 and NAC6 in vitro. Overexpression of zma‐miR164e resulted in the down‐regulation of these genes above and the failure of seed formation in Arabidopsis pods, with the increased branch number. These findings provide insights into the mechanism of seed development and the improvement of molecular marker‐assisted selection (MAS) for high‐yield breeding in maize

Planning and design of forest park rehabilitation base oriented to an artificial intelligence algorithm

A water ecosystem is a dynamic balance system with a certain structure and function, which is composed of aquatic organism community and water environment interaction and mutual restriction through material circulation and energy flow. Living in an urban environment for a long time can make people suffer from ‘urban disease’, which can seriously affect their physical and mental health. Forest rehabilitation is a new form of outdoor activity in many countries, which has been gradually promoted by society in recent years. Many studies have confirmed that forest environments have positive impacts on the human body and mind, so forest healthcare and treatment are crucial to the prevention and treatment of ‘urban diseases’. This study is based on artificial intelligence (AI) to carry out the planning and design of the forest health base. According to sensory design theories including air factor, somatosensory factor, and audiovisual factor, this paper proposed different landscape configuration methods to enhance health and well-being. Finally, it was found that in the planning and design of the health base, when the human comfort index is greater than 85 and less than 20, it is very uncomfortable for the human body

Effects of chronic sleep deprivation on the extracellular signal-regulated kinase pathway in the temporomandibular joint of rats.

OBJECTIVES: To examine the possible involvement and regulatory mechanisms of extracellular signal-regulated kinase (ERK) pathway in the temporomandibular joint (TMJ) of rats subjected to chronic sleep deprivation (CSD). METHODS: Rats were subjected to CSD using the modified multiple platform method (MMPM). The serum levels of corticosterone (CORT) and adrenocorticotropic hormone (ACTH) were tested and histomorphology and ultrastructure of the TMJ were observed. The ERK and phospho-ERK (p-ERK) expression levels were detected by Western blot analysis, and the MMP-1, MMP-3, and MMP-13 expression levels were detected by real-time quantitative polymerase chain reaction (PCR) and Western blotting. RESULTS: The elevated serum CORT and ACTH levels confirmed that the rats were under CSD stress. Hematoxylin and eosin (HE) staining and scanning electron microscopy (SEM) showed pathological alterations in the TMJ following CSD; furthermore, the p-ERK was activated and the mRNA and protein expression levels of MMP-1, MMP-3, and MMP-13 were upregulated after CSD. In the rats administered with the selective ERK inhibitor U0126, decreased tissue destruction was observed. Phospho-ERK activation was visibly blocked and the MMP-1, MMP-3, and MMP-13 mRNA and protein levels were lower than the corresponding levels in the CSD without U0126 group. CONCLUSION: These findings indicate that CSD activates the ERK pathway and upregulates the MMP-1, MMP-3, and MMP-13 mRNA and protein levels in the TMJ of rats. Thus, CSD induces ERK pathway activation and causes pathological alterations in the TMJ. ERK may be associated with TMJ destruction by promoting the expression of MMPs

p-Type SnO thin layers on n-type SnS2 nanosheets with enriched surface defects and embedded charge transfer for lithium ion batteries

In this work, for the first time, we have successfully constructed defective heterointerfaces of p-SnO on n-SnS2 nanosheets by plasma treatment to significantly improve Li+ and electron diffusion kinetics. The defective heterointerfaces show advanced electrochemical performance as the anode in Li-ion batteries

One-Pot Synthesis of Fe₂O₃ Nanoparticles on Nitrogen-Doped Graphene as Advanced Supercapacitor Electrode Materials

Fe₂O₃ supported on nitrogen-doped graphene (Fe₂O₃/N-rGO) hydrogel was prepared by a facial one-pot hydrothermal method. The efficient Fe₂O₃ loading and nitrogen doping of graphene was realized with this method. The morphology and structure of the samples were characterized by scanning electron microscopy, high-resolution transmission electron microscopy, thermal gravimetric analysis, Raman spectra, X-ray diffraction, and nitrogen isothermal adsorption–desorption. The chemical environment of the surface composition of the samples was recorded by X-ray photoelectron spectroscopy. The electrochemical performance was tested with a three-electrode system in the aqueous electrolyte of 1 M KOH. The electrochemical measurement demonstrated that Fe₂O₃/N-rGO shows a specific capacitance as high as 618 F g^–1 at a discharge current density of 0.5 A g^–1. Even at the current density of 10 A g^–1, the specific capacitance is still as high as 350 F g^–1. After 5000 cycles, the capacity retention is still maintained at 56.7%