On the Singularity of Multivariate Hermite Interpolation of Total Degree

We study the singularity of multivariate Hermite interpolation of type total degree on m nodes with 3+d<m≤d(d+3)/2. We first check the number of the interpolation conditions and the dimension of interpolation space. And then the singularity of the interpolation schemes is decided for most cases. Also some regular interpolation schemes are derived, a few of which are proved due to theoretical argument and most of which are verified by numerical method. There are some schemes to be decided and left open

Molecular-Level Insight into Selective Catalytic Reduction of NOx with NH3 to N-2 over a Highly Efficient Bifunctional V-alpha-MnOx Catalyst at Low Temperature

This work was supported by the National Natural Science Foundation of China (Nos. 21477046, 21333003, and 21673072) and Key Technology R&D Program of Shandong Province (No. 2016ZDJS11A03). The authors also acknowledge computing time support from the Special Program for Applied Research on Super Computation of the NSFC-Guangdong Joint Fund (the second phase) under Grant No. U1501501.Peer reviewedPostprin

Characterization of 35 novel microsatellite DNA markers from the duck (Anas platyrhynchos) genome and cross-amplification in other birds

In order to study duck microsatellites, we constructed a library enriched for (CA)n, (CAG)n, (GCC)n and (TTTC)n. A total of 35 pairs of primers from these microsatellites were developed and used to detect polymorphisms in 31 unrelated Peking ducks. Twenty-eight loci were polymorphic and seven loci were monomorphic. A total of 117 alleles were observed from these polymorphic microsatellite markers, which ranged from 2 to 14 with an average of 4.18 per locus. The frequencies of the 117 alleles ranged from 0.02 to 0.98. The highest heterozygosity (0.97) was observed at the CAUD019 microsatellite locus and the lowest heterozygosity (0.04) at the CAUD008 locus, and 11 loci had heterozygosities greater than 0.50 (46.43%). The polymorphism information content (PIC) of 28 loci ranged from 0.04 to 0.88 with an average of 0.42. All the above markers were used to screen the polymorphism in other bird species. Two markers produced specific monomorphic products with the chicken DNA. Fourteen markers generated specific fragments with the goose DNA: 5 were polymorphic and 9 were monomorphic. But no specific product was detected with the peacock DNA. Based on sequence comparisons of the flanking sequence and repeat, we conclude that 2 chicken loci and 14 goose loci were true homologous loci of the duck loci. The microsatellite markers identified and characterized in the present study will contribute to the genetic map, quantitative traits mapping, and phylogenetic analysis in the duck and goose

Evaluation of pharmacological and pharmacokinetic herb-drug interaction between irinotecan hydrochloride injection and Kangai injection in colorectal tumor-bearing mice and healthy rats

Introduction: Kangai (KA) injection, a Chinese herbal injection, is often used in combination with irinotecan (CPT-11) to enhance the effectiveness of anti-colorectal cancer treatment and alleviate side effects. However, the combined administration of this herb-drug pair remains controversial due to limited pre-clinical evidence and safety concerns. This study aimed to determine the pre-clinical herb-drug interactions between CPT-11 and KA injection to provide a reference for their clinical co-administration.Methods: In the pharmacological study, BALB/c mice with CT26 colorectal tumors were divided into four groups and treated with vehicle alone (0.9% saline), CPT-11 injection (100 mg/kg), KA injection (10 mL/kg), or a combination of CPT-11 and KA injection, respectively. The tumor volume of mice was monitored daily to evaluate the therapeutic effect. Daily body weight, survival rate, hematopoietic toxicity, immune organ indices, and gut toxicity were analyzed to study the adverse effects. Healthy Sprague-Dawley rats in the pharmacokinetic study were administered KA injection only (4 mL/kg), or a combination of CPT-11 injection (20 mg/kg) and KA injection, respectively. Six key components of KA injection (oxymatrine, matrine, ginsenoside Rb1, Rg1, Re, and astragaloside IV) in rat plasma samples collected within 24 h after administration were determined by LC-MS/MS.Results: The pharmacological study indicated that KA injection has the potential to enhance the anti-colorectal cancer efficacy of CPT-11 injection and alleviate the severe weight loss induced by CPT-11 injection in tumor-bearing mice. The pharmacokinetic study revealed that co-administration resulted in inhibition of oxymatrine metabolism in rats, evidenced by the significantly reduced Cmax and AUC0-t of its metabolite, matrine (p &lt; 0.05), from 2.23 ± 0.24 to 1.38 ± 0.12 μg/mL and 8.29 ± 1.34 to 5.30 ± 0.79 μg h/mL, respectively. However, due to the similar efficacy of oxymatrine and matrine, this may not compromise the anti-cancer effect of this herb-drug pair.Discussion: This study clarified the pre-clinical pharmacology and pharmacokinetic benefits and risks of the CPT-11-KA combination and provided a reference for their clinical co-administration

Avian Influenza: Should China Be Alarmed?

Avian influenza has emerged as one of the primary public health concern of the 21st century. Influenza strain H5N1 is capable of incidentally infecting humans and other mammals. Since their reemergence in 2003, highly pathogenic avian influenza A (H5N1) viruses have been transmitted from poultry to humans (by direct or indirect contact with infected birds) in several provinces of Mainland China, which has resulted in 22 cases of human infection and has created repercussions for the Chinese economy. People have been concerned whether a new pandemic will occur in the future. The eradication of pathogenic avian influenza viruses appears to be the most effective way to prevent an influenza pandemic. This paper will examine the features of H5N1, including incidence, infection, immunity, clinical management, prevention and control, and therapy in Mainland China

Dynamismes de l'organisation concentrique de la population à Pékin

In the eighties, a new distribution of the population took place in the municipality of Peking. According to the territorial division used here, the inner circle lost inhabitants : demographic growth of the median circle was high and that of the outer circle low. This was due to the urban modernization taking place, the development of a market economy and both internal and external migrations. The tertiary was concentrated in the town center and the residential functions reached the outskirts. Lastly, the migrants tend to live on the edge of the urban space, where rents are lower.Dans les années 1980, la municipalité de Pékin a connu une nouvelle répartition de sa population. Suivant la division territoriale ici employée, le cercle intérieur a perdu des habitants ; la croissance démographique du cercle médian fut forte et celle du cercle extérieur faible. Cela vient de la modernisation urbaine en cours, du développement d'une économie de marché et des migrations tant internes qu'externes. Le tertiaire s'est concentré dans le centre-ville et les fonctions résidentielles ont gagné la périphérie. Enfin, les migrants ont tendance à habiter à la limite de l'espace urbain, là où les loyers sont moins chers.Hu Zhaoliang, Foggin Peter M. Dynamismes de l'organisation concentrique de la population à Pékin. In: Villes en parallèle, n°23-24, décembre 1996. Villes chinoises. pp. 98-109

Investigations on the Unsteady Aerodynamic Characteristics of a Horizontal-Axis Wind Turbine during Dynamic Yaw Processes

Wind turbines inevitably experience yawed flows, resulting in fluctuations of the angle of attack (AOA) of airfoils, which can considerably impact the aerodynamic characteristics of the turbine blades. In this paper, a horizontal-axis wind turbine (HAWT) was modeled using a structured grid with multiple blocks. Then, the aerodynamic characteristics of the wind turbine were investigated under static and dynamic yawed conditions using the Unsteady Reynolds Averaged Navier-Stokes (URANS) method. In addition, start-stop yawing rotations at two different velocities were studied. The results suggest that AOA fluctuation under yawing conditions is caused by two separate effects: blade advancing &amp; retreating and upwind &amp; downwind yawing. At a positive yaw angle, the blade advancing &amp; retreating effect causes a maximum AOA at an azimuth angle of 0&deg;. Moreover, the effect is more dominant in inboard airfoils compared to outboard airfoils. The upwind &amp; downwind yawing effect occurs when the wind turbine experiences dynamic yawing motion. The effect increases the AOA when the blade is yawing upwind and vice versa. The phenomena become more dominant with the increase of yawing rate. The torque of the blade in the forward yawing condition is much higher than in backward yawing, owing to the reversal of the yaw velocity