Elderly hospitalization and the New-type Rural Cooperative Medical Scheme (NCMS) in China: multi-stage cross-sectional surveys of Jiangxi province

Studies assessing the impacts of China's New-type Rural Cooperative Medical Scheme (NCMS) reform of 2003 among rural elderly have been limited. Method: Multistage stratified cluster sampling household surveys of 1838, 1924, 1879, 1888, 1890 and 1896 households from 27 villages in Jiangxi province were conducted in 2003/2004, 2006, 2008, 2010, 2012 and 2014. Data from older adults age 65 and above were analyzed. Weighted logistic regression was applied to find factors of elderly hospitalization services. Results: Since 2003, hospitalization rates for elderly increased, while rates of patients leaving against medical advice and patients avoiding the hospital decreased (P < 0.05). Factors associated with a higher likelihood of reporting hospitalization in the past year for elderly were the per-capita financial level V in 2012 for NCMS (Adjusted Odds Ratios [aOR]: 2.295), the level VI in 2014 (aOR: 3.045) versus the level I in 2003 and chronic disease (aOR: 2.089) versus not having a chronic disease. Lower rate of elderly left against medical advice was associated with the financial level V in 2012 (aOR: 0.099) versus the level I. The higher rate of hospital avoidance was associated with chronic disease status (aOR: 5.759) versus not having a chronic disease, while the lower rate was associated with the financial level VI in 2014 (aOR: 0.143) versus the level I. Among reporting reasons for elderly hospital avoidance, the cost-related reasons just dropped slightly over the years. Conclusions: NCMS improved access to health services for older adults. The utilization of hospitalization services for rural elderly increased gradually, but cost-related barriers remained the primary reporting barrier to accessing hospitalization services

BlockEmulator: An Emulator Enabling to Test Blockchain Sharding Protocols

Numerous blockchain simulators have been proposed to allow researchers to simulate mainstream blockchains. However, we have not yet found a testbed that enables researchers to develop and evaluate their new consensus algorithms or new protocols for blockchain sharding systems. To fill this gap, we develop BlockEmulator, which is designed as an experimental platform, particularly for emulating blockchain sharding mechanisms. BlockEmulator adopts a lightweight blockchain architecture such that developers can only focus on implementing their new protocols or mechanisms. Using layered modules and useful programming interfaces offered by BlockEmulator, researchers can implement a new protocol with minimum effort. Through experiments, we test various functionalities of BlockEmulator in two steps. Firstly, we prove the correctness of the emulation results yielded by BlockEmulator by comparing the theoretical analysis with the observed experiment results. Secondly, other experimental results demonstrate that BlockEmulator can facilitate the measurement of a series of metrics, including throughput, transaction confirmation latency, cross-shard transaction ratio, the queuing size of transaction pools, workload distribution across blockchain shards, etc. We have made BlockEmulator open-source in Github

Three-Dimensional and Chemical Mapping of Intracellular Signaling Nanodomains in Health and Disease with Enhanced Expansion Microscopy

Nanodomains are intracellular foci which transduce signals between major cellular compartments. One of the most ubiquitous signal transducers, the ryanodine receptor (RyR) calcium channel, is tightly clustered within these nanodomains. Super-resolution microscopy has previously been used to visualize RyR clusters near the cell surface. A majority of nanodomains located deeper within cells have remained unresolved due to limited imaging depths and axial resolution of these modalities. A series of enhancements made to expansion microscopy allowed individual RyRs to be resolved within planar nanodomains at the cell periphery and the curved nanodomains located deeper within the interiors of cardiomyocytes. With a resolution of ∼ 15 nm, we localized both the position of RyRs and their individual phosphorylation for the residue Ser2808. With a three-dimensional imaging protocol, we observed disturbances to the RyR arrays in the nanometer scale which accompanied right-heart failure caused by pulmonary hypertension. The disease coincided with a distinct gradient of RyR hyperphosphorylation from the edge of the nanodomain toward the center, not seen in healthy cells. This spatial profile appeared to contrast distinctly from that sustained by the cells during acute, physiological hyperphosphorylation when they were stimulated with a β-adrenergic agonist. Simulations of RyR arrays based on the experimentally determined channel positions and phosphorylation signatures showed how the nanoscale dispersal of the RyRs during pathology diminishes its intrinsic likelihood to ignite a calcium signal. It also revealed that the natural topography of RyR phosphorylation could offset potential heterogeneity in nanodomain excitability which may arise from such RyR reorganization

Cultural Protection and Inheritance of Red Buildings from the Perspective of Rural Revitalization : A Case Study of the Former Site of "Third Line" Military Factory in Pengfang, Jiangxi Province

This paper makes an investigation and analysis of the existing red buildings in Pengfang Township, and puts forward the circular development model of "Red Building + Rural Tourism" after systematic arrangement. And through the dialectical perspective of the protection, inheritance, development and utilization of architectural culture under the revitalization of the countryside, this paper observes how the villages with red buildings help to boost the rural economy by integrating its own internal and external resources under the background of the great revival of the national rural traditional culture, so as to realize the protective development of rural red buildings

Autaptic modulation-induced neuronal electrical activities and wave propagation on network under electromagnetic induction

Based on an improved HR neuron model, the effects of electrical and chemical autapses on the firing activities of single neurons are studied, and the wave propagation in forward feedback neural network is also discussed by considering autapstic regulation under different intensities of electromagnetic induction. It is found that the electrical activities of single neuron can be changed by exerting excitatory or inhibitory of electrical and chemical autapses. With different feedback gains of electromagnetic induction current, membrane potential shows the oscillatory solutions and steady states. Under the condition of different autapse or electromagnetic induction, the propagation of electrical activities caused by the central neuron is transformed in the forward feedback network. Moreover, the spatial synchronization of the network will be changed by choosing different coupling intensities and feedback gains. It is proved that the electrical and chemical autapses play a significant role in firing modes of single neuron and the wave propagation of the forward feedback networks under the electromagnetic induction