Stromal Gli2 activity coordinates a niche signaling program for mammary epithelial stem cells

The stem cell niche is a complex local signaling microenvironment that sustains stem cell activity during organ maintenance and regeneration. The mammary gland niche must support its associated stem cells while also responding to systemic hormonal regulation that triggers pubertal changes. We find that Gli2, the major Hedgehog pathway transcriptional effector, acts within mouse mammary stromal cells to direct a hormoneresponsive niche signaling program by activating expression of factors that regulate epithelial stem cells as well as receptors for the mammatrophic hormones estrogen and growth hormone.Whereas prior studies implicate stem cell defects in human disease, this work shows that niche dysfunction may also cause disease, with possible relevance for human disorders and in particular the breast growth pathogenesis associated with combined pituitary hormone deficiency. Copyright 2016 by the American Association for the Advancement of Science, all rights reserved.116Ysciescopu

High Magnetic Field Behaviour of the Triangular Lattice Antiferromagnet, CuFeO_2

The high magnetic field behaviour of the triangular lattice antiferromagnet CuFeO_2 is studied using single crystal neutron diffraction measurements in a field of up to 14.5 T and also by magnetisation measurements in a field of up to 12 T. At low temperature, two well-defined first order magnetic phase transitions are found in this range of applied magnetic field (H // c): at H_c1=7.6(3)/7.1(3) T and H_c2=13.2(1)/12.7(1) T when ramping the field up/down. In a field above H_c2 the magnetic Bragg peaks show unusual history dependence. In zero field T_N1=14.2(1) K separates a high temperature paramagnetic and an intermediate incommensurate structure, while T_N2=11.1(3) K divides an incommensurate phase from the low-temperature 4-sublattice ground state. The ordering temperature T_N1 is found to be almost field independent, while T_N2 decreases noticeably in applied field. The magnetic phase diagram is discussed in terms of the interactions between an applied magnetic field and the highly frustrated magnetic structure of CuFeO_2Comment: 7 pages, 8 figures in ReVTeX. To appear in PR

Meridional Circulation and Global Solar Oscillations

We investigate the influence of large-scale meridional circulation on solar p-modes by quasi-degenerate perturbation theory, as proposed by \cite{lavely92}. As an input flow we use various models of stationary meridional circulation obeying the continuity equation. This flow perturbs the eigenmodes of an equilibrium model of the Sun. We derive the signatures of the meridional circulation in the frequency multiplets of solar p-modes. In most cases the meridional circulation leads to negative average frequency shifts of the multiplets. Further possible observable effects are briefly discussed.Comment: 14 pages, 5 figures, submittted to Solar Physics Topical Issue "HELAS

Dirac-harmonic maps from degenerating spin surfaces I: the Neveu-Schwarz case

We study Dirac-harmonic maps from degenerating spin surfaces with uniformly bounded energy and show the so-called generalized energy identity in the case that the domain converges to a spin surface with only Neveu-Schwarz type nodes. We find condition that is both necessary and sufficient for the $W^{1,2} \times L^{4}$ modulo bubbles compactness of a sequence of such maps.Comment: 24 page

Helioseismology of Sunspots: A Case Study of NOAA Region 9787

Various methods of helioseismology are used to study the subsurface properties of the sunspot in NOAA Active Region 9787. This sunspot was chosen because it is axisymmetric, shows little evolution during 20-28 January 2002, and was observed continuously by the MDI/SOHO instrument. (...) Wave travel times and mode frequencies are affected by the sunspot. In most cases, wave packets that propagate through the sunspot have reduced travel times. At short travel distances, however, the sign of the travel-time shifts appears to depend sensitively on how the data are processed and, in particular, on filtering in frequency-wavenumber space. We carry out two linear inversions for wave speed: one using travel-times and phase-speed filters and the other one using mode frequencies from ring analysis. These two inversions give subsurface wave-speed profiles with opposite signs and different amplitudes. (...) From this study of AR9787, we conclude that we are currently unable to provide a unified description of the subsurface structure and dynamics of the sunspot.Comment: 28 pages, 18 figure

Tensor Correlations Measured in 3He(e,e'pp)n

We have measured the 3He(e,e'pp)n reaction at an incident energy of 4.7 GeV over a wide kinematic range. We identified spectator correlated pp and pn nucleon pairs using kinematic cuts and measured their relative and total momentum distributions. This is the first measurement of the ratio of pp to pn pairs as a function of pair total momentum, $p_{tot}$. For pair relative momenta between 0.3 and 0.5 GeV/c, the ratio is very small at low $p_{tot}$ and rises to approximately 0.5 at large $p_{tot}$. This shows the dominance of tensor over central correlations at this relative momentum.Comment: 4 pages, 4 figures, submitted to PR

Measurement of the nuclear multiplicity ratio for Ks0K^0_s hadronization at CLAS

The influence of cold nuclear matter on lepto-production of hadrons in semi-inclusive deep inelastic scattering is measured using the CLAS detector in Hall B at Jefferson Lab and a 5.014 GeV electron beam. We report the $K_s^0$ multiplicity ratios for targets of C, Fe, and Pb relative to deuterium as a function of the fractional virtual photon energy $z$ transferred to the $K_s^0$ and the transverse momentum squared $p_{T}^2$ of the $K_s^0$. We find that the multiplicity ratios for $K^0_s$ are reduced in the nuclear medium at high $z$ and low $p_{T}^2$, with a trend for the $K^0_s$ transverse momentum to be broadened in the nucleus for large $p_{T}^2$.Comment: Submitted to Phys. Lett.