A PCA-SMO Based Hybrid Classification Model for Predictions in Precision Agriculture

The human population is growing at an extremely rapid rate, the demand of food supplies for the survival and sustainability of life is a gleaming challenge. Each living being in the planet gets bestowed with the healthy food to remain active and healthy. Agriculture is a domain which is extremely important as it provides the fundamental resources for survival in terms of supplying food and thus the economy of the entire world is highly dependent on agricultural production. The agricultural production is often affected by various environmental and geographical factors which are difficult to avoid being part of nature. Thus, it requires proactive mitigation plans to reduce any detrimental effect caused by the imbalance of these factors. Precision agriculture is an approach that incorporates information technology in agriculture management, the needs of crops and farming fields are fulfilled to optimized crop health and resultant crop production. The proposed study involves an ambient intelligence-based implementation using machine learning to classify diseases in tomato plants based on the images of its leaf dataset. To analytically evaluate the performance of the framework, a publicly available plant-village dataset is used which is transformed to appropriate form using one-hot encoding technique to meet the needs of the machine learning algorithm. The transformed data is dimensionally reduced by Principal Component Analysis (PCA) technique and further the optimal parameters are selected using Spider Monkey Optimization (SMO) approach. The most relevant features as selected using the Hybrid PCA-SMO technique fed into a Deep Neural Networks (DNN) model to classify the tomato diseases. The optimal performance of the DNN model after implementing dimensionality reduction by Hybrid PCA-SMO technique reached at 99% accuracy was achieved in training and 94% accuracy was achieved after testing the model for 20 epochs. The proposed model is evaluated based on accuracy and loss rate metrics; it justifies the superiority of the approach

Lipid-lowering drugs affect lung cancer risk via sphingolipid metabolism: a drug-target Mendelian randomization study

Background: The causal relationship between lipid-lowering drug (LLD) use and lung cancer risk is controversial, and the role of sphingolipid metabolism in this effect remains unclear.Methods: Genome-wide association study data on low-density lipoprotein (LDL), apolipoprotein B (ApoB), and triglycerides (TG) were used to develop genetic instrumental variables (IVs) for LLDs. Two-step Mendelian randomization analyses were performed to examine the causal relationship between LLDs and lung cancer risk. The effects of ceramide, sphingosine-1-phosphate (S1P), and ceramidases on lung cancer risk were explored, and the proportions of the effects of LLDs on lung cancer risk mediated by sphingolipid metabolism were calculated.Results:APOB inhibition decreased the lung cancer risk in ever-smokers via ApoB (odds ratio [OR] 0.81, 95% confidence interval [CI] 0.70–0.92, p = 0.010), LDL (OR 0.82, 95% CI 0.71–0.96, p = 0.040), and TG (OR 0.63, 95% CI 0.46–0.83, p = 0.015) reduction by 1 standard deviation (SD), decreased small-cell lung cancer (SCLC) risk via LDL reduction by 1 SD (OR 0.71, 95% CI 0.56–0.90, p = 0.016), and decreased the plasma ceramide level and increased the neutral ceramidase level. APOC3 inhibition decreased the lung adenocarcinoma (LUAD) risk (OR 0.60, 95% CI 0.43–0.84, p = 0.039) but increased SCLC risk (OR 2.18, 95% CI 1.17–4.09, p = 0.029) via ApoB reduction by 1 SD. HMGCR inhibition increased SCLC risk via ApoB reduction by 1 SD (OR 3.04, 95% CI 1.38–6.70, p = 0.014). The LPL agonist decreased SCLC risk via ApoB (OR 0.20, 95% CI 0.07–0.58, p = 0.012) and TG reduction (OR 0.58, 95% CI 0.43–0.77, p = 0.003) while increased the plasma S1P level. PCSK9 inhibition decreased the ceramide level. Neutral ceramidase mediated 8.1% and 9.5% of the reduced lung cancer risk in ever-smokers via ApoB and TG reduction by APOB inhibition, respectively, and mediated 8.7% of the reduced LUAD risk via ApoB reduction by APOC3 inhibition.Conclusion: We elucidated the intricate interplay between LLDs, sphingolipid metabolites, and lung cancer risk. Associations of APOB, APOC3, and HMGCR inhibition and LPL agonist with distinct lung cancer risks underscore the multifaceted nature of these relationships. The observed mediation effects highlight the considerable influence of neutral ceramidase on the lung cancer risk reduction achieved by APOB and APOC3 inhibition

Surface passivation for highly active, selective, stable, and scalable CO2 electroreduction

Electrochemical conversion of CO2 to formic acid using Bismuth catalysts is one the most promising pathways for industrialization. However, it is still difficult to achieve high formic acid production at wide voltage intervals and industrial current densities because the Bi catalysts are often poisoned by oxygenated species. Herein, we report a Bi3S2 nanowire-ascorbic acid hybrid catalyst that simultaneously improves formic acid selectivity, activity, and stability at high applied voltages. Specifically, a more than 95% faraday efficiency was achieved for the formate formation over a wide potential range above 1.0 V and at ampere-level current densities. The observed excellent catalytic performance was attributable to a unique reconstruction mechanism to form more defective sites while the ascorbic acid layer further stabilized the defective sites by trapping the poisoning hydroxyl groups. When used in an all-solid-state reactor system, the newly developed catalyst achieved efficient production of pure formic acid over 120 hours at 50 mA cm–2 (200 mA cell current)

Natural Coevolution of Tumor and Immunoenvironment in Glioblastoma.

Isocitrate dehydrogenase (IDH) wild-type glioblastoma (GBM) has a dismal prognosis. A better understanding of tumor evolution holds the key to developing more effective treatment. Here we study GBM\u27s natural evolutionary trajectory by using rare multifocal samples. We sequenced 61,062 single cells from eight multifocal IDH wild-type primary GBMs and defined a natural evolution signature (NES) of the tumor. We show that the NES significantly associates with the activation of transcription factors that regulate brain development, including MYBL2 and FOSL2. Hypoxia is involved in inducing NES transition potentially via activation of the HIF1A-FOSL2 axis. High-NES tumor cells could recruit and polarize bone marrow-derived macrophages through activation of the FOSL2-ANXA1-FPR1/3 axis. These polarized macrophages can efficiently suppress T-cell activity and accelerate NES transition in tumor cells. Moreover, the polarized macrophages could upregulate CCL2 to induce tumor cell migration. SIGNIFICANCE: GBM progression could be induced by hypoxia via the HIF1A-FOSL2 axis. Tumor-derived ANXA1 is associated with recruitment and polarization of bone marrow-derived macrophages to suppress the immunoenvironment. The polarized macrophages promote tumor cell NES transition and migration. This article is highlighted in the In This Issue feature, p. 2711

Aggregation-Induced Emission (AIE), Life and Health

Light has profoundly impacted modern medicine and healthcare, with numerous luminescent agents and imaging techniques currently being used to assess health and treat diseases. As an emerging concept in luminescence, aggregation-induced emission (AIE) has shown great potential in biological applications due to its advantages in terms of brightness, biocompatibility, photostability, and positive correlation with concentration. This review provides a comprehensive summary of AIE luminogens applied in imaging of biological structure and dynamic physiological processes, disease diagnosis and treatment, and detection and monitoring of specific analytes, followed by representative works. Discussions on critical issues and perspectives on future directions are also included. This review aims to stimulate the interest of researchers from different fields, including chemistry, biology, materials science, medicine, etc., thus promoting the development of AIE in the fields of life and health

Global Policy Construction in Modular Reinforcement Learning

We propose a modular reinforcement learning algorithm which decomposes a Markov decision process into independent modules. Each module is trained using Sarsa(lambda). We introduce three algorithms for forming global policy from modules policies, and demonstrate our results using a 2D grid world

Recent Development in Phosphonic Acid-Based Organic Coatings on Aluminum

Research on corrosion protection of aluminum has intensified over the past decades due to environmental concerns regarding chromate-based conversion coatings and also the higher material performance requirements in automotive and aviation industries. Phosphonic acid-based organic and organic-inorganic coatings are increasingly investigated as potential replacements of toxic and inefficient surface treatments for aluminum. In this review, we have briefly summarized recent work (since 2000) on pretreatments or coatings based on various phosphonic acids for aluminum and its alloys. Surface characterization methods, the mechanism of bonding of phosphonic acids to aluminum surface, methods for accessing the corrosion behavior of the treated aluminum, and applications have been discussed. There is a clear trend to develop multifunctional phosphonic acids and to produce hybrid organic-inorganic coatings. In most cases, the phosphonic acids are either assembled as a monolayer on the aluminum or incorporated in a coating matrix on top of aluminum, which is either organic or organic-inorganic in nature. Increased corrosion protection has often been observed. However, much work is still needed in terms of their ecological impact and adaptation to the industrially-feasible process for possible commercial exploitation

A PCA-SMO Based Hybrid Classification Model for Predictions in Precision Agriculture

The human population is growing at an extremely rapid rate, the demand of food supplies for the survival and sustainability of life is a gleaming challenge. Each living being in the planet gets bestowed with the healthy food to remain active and healthy. Agriculture is a domain which is extremely important as it provides the fundamental resources for survival in terms of supplying food and thus the economy of the entire world is highly dependent on agricultural production. The agricultural production is often affected by various environmental and geographical factors which are difficult to avoid being part of nature. Thus, it requires proactive mitigation plans to reduce any detrimental effect caused by the imbalance of these factors. Precision agriculture is an approach that incorporates information technology in agriculture management, the needs of crops and farming fields are fulfilled to optimized crop health and resultant crop production. The proposed study involves an ambient intelligence-based implementation using machine learning to classify diseases in tomato plants based on the images of its leaf dataset. To analytically evaluate the performance of the framework, a publicly available plant-village dataset is used which is transformed to appropriate form using one-hot encoding technique to meet the needs of the machine learning algorithm. The transformed data is dimensionally reduced by Principal Component Analysis (PCA) technique and further the optimal parameters are selected using Spider Monkey Optimization (SMO) approach. The most relevant features as selected using the Hybrid PCA-SMO technique fed into a Deep Neural Networks (DNN) model to classify the tomato diseases. The optimal performance of the DNN model after implementing dimensionality reduction by Hybrid PCA-SMO technique reached at 99% accuracy was achieved in training and 94% accuracy was achieved after testing the model for 20 epochs. The proposed model is evaluated based on accuracy and loss rate metrics; it justifies the superiority of the approach