Association of subclinical myocardial injury with arterial stiffness in patients with type 2 diabetes mellitus

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Predictive value of high-sensitivity troponin-I for future adverse cardiovascular outcome in stable patients with type 2 diabetes mellitus

INTRODUCTION: High-sensitivity cardiac troponin I(hs-TnI) and T levels(hs-TnT) are sensitive biomarkers of cardiomyocyte turnover or necrosis. Prior studies of the predictive role of hs-TnT in type 2 diabetes mellitus(T2DM) patients have yielded conflicting results. This study aimed to determine whether hs-TnI, which is detectable in a higher proportion of normal subjects than hsTnT, is associated with a major adverse cardiovascular event(MACE) in T2DM patients. METHODS AND RESULTS: We compared hs-TnI level in stored serum samples from 276 consecutive patients (mean age 65 +/- 10 years; 57% male) with T2DM with that of 115 age-and sex-matched controls. All T2DM patients were prospectively followed up for at least 4 years for incidence of MACE including heart failure(HF), myocardial infarction(MI) and cardiovascular mortality. At baseline, 274(99%) patients with T2DM had detectable hs-TnI, and 57(21%) had elevated hs-TnI (male: 8.5 ng/L, female: 7.6 ng/L, above the 99th percentile in healthy controls). A total of 43 MACE occurred: HF(n = 18), MI(n = 11) and cardiovascular mortality(n = 14). Kaplan-Meier analysis showed that an elevated hs-TnI was associated with MACE, HF, MI and cardiovascular mortality. Although multivariate analysis revealed that an elevated hs-TnI independently predicted MACE, it had limited sensitivity(62.7%) and positive predictive value(38.5%). Contrary to this, a normal hs-TnI level had an excellent negative predictive value(92.2%) for future MACE in patients with T2DM. CONCLUSION: The present study demonstrates that elevated hs-TnI in patients with T2DM is associated with increased MACE, HF, MI and cardiovascular mortality. Importantly, a normal hs-TnI level has an excellent negative predictive value for future adverse cardiovascular events during long-term follow-up.published_or_final_versio

Mode Change of a Gamma-Ray Pulsar, PSR J2021+4026

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Isotope effect on the transition temperature TcT_c in Fe-based superconductors: the current status

The results of the Fe isotope effect (Fe-IE) on the transition temperature $T_c$ obtained up to date in various Fe-based high temperature superconductors are summarized and reanalyzed by following the approach developed in [Phys. Rev. B 82, 212505 (2010)]. It is demonstrated that the very controversial results for Fe-IE on $T_c$ are caused by small structural changes occurring simultaneously with the Fe isotope exchange. The Fe-IE exponent on $T_c$ [$\alpha_{\rm Fe}=-(\Delta T_c/T_c)/(\Delta M/M)$, $M$ is the isotope mass] needs to be decomposed into two components with the one related to the structural changes ($\alpha_{\rm Fe}^{\rm str}$) and the genuine (intrinsic) one ($\alpha_{\rm Fe}^{\rm int}$). The validity of such decomposition is further confirmed by the fact that $\alpha_{\rm Fe}^{\rm int}$ coincides with the Fe-IE exponent on the characteristic phonon frequencies $\alpha_{\rm Fe}^{\rm ph}$ as is reported in recent EXAFS and Raman experiments.Comment: 7 pages, 4 figures. The paper is partially based on the results published in [New J. Phys. 12, 073024 (2010) = arXiv:1002.2510] and [Phys. Rev. B 82, 212505 (2010) = arXiv:1008.4540

Distributions of deposits and hydrogen on the upper and lower TDUs3 target elements of Wendelstein 7-X

Distributions of deposits and hydrogen (H) on the graphite divertor target elements TM4h4 and TM3v5 in the test divertor units 3 (TDUs3) of Wendelstein 7-X (W7-X) are studied. The TM4h4 and TM3v5 are located at the magnetically symmetric positions in the upper and lower divertor. The microstructure of the deposition layer is characterized by a transmission electron microscope (TEM) combined with a focused ion beam (FIB). Metallic deposits such as iron (Fe), molybdenum (Mo), chromium (Cr) are detected in the deposition layer by energy-dispersive x-ray spectroscopy (EDS). The depth-resolved distribution patterns of boron (B) and metallic deposits on upper and lower horizontal (h) divertor target elements TDUs3-TM4h4 as well as upper and lower vertical (v) divertor target elements TDUs3-TM3v5 are clarified by glow discharge optical emission spectrometry (GDOES). Results for both TDUs3-TM4h4 and TDUs3-TM3v5 show that the B deposition regions exhibit higher H retention due to the co-deposition with deposits. On the other hand, up-down asymmetries in B deposition caused by particle drift exist on both TDUs3-TM4h4 and TDUs3-TM3v5. The B deposition amount on upper TDUs3-TM4h4 is 40% smaller than that on lower TDUs3-TM4h4. While for the vertical target elements, the B deposition amount on upper TDUs3-TM3v5 is 35% larger than that on lower TDUs3-TM3v5. Meanwhile, a shift of around 3 cm in B deposition peaks is observed on upper and lower TDUs3-TM4h4 and TDUs3-TM3v5. Results of numerical simulation of carbon deposition/erosion profiles on the target elements using ERO2.0 code and power flux measured by infrared cameras are shown and compared with the above mentioned B profiles

Simulation of multilevel cell spin transfer switching in a full-Heusler alloy spin-valve nanopillar

Author name used in this publication: Shi, S. Q.2012-2013 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

Ion-scale kinetic Alfvén turbulence: MMS measurements of the Alfvén ratio in the magnetosheath

Turbulence in the Earth's magnetosheath at ion kinetic scales is investigated with the magnetospheric multiscale spacecraft. Several possibilities in the wave paradigm have been invoked to explain plasma turbulence at ion kinetic scales such as kinetic Alfvén, slow, or magnetosonic waves. To differentiate between these different plasma waves is a challenging task, especially since some waves, in particular, kinetic slow waves and kinetic Alfvén waves, share some properties making the possibility to distinguishing between them very difficult. Using the excellent time resolution data set provided from both the fluxgate magnetometer and the Fast Plasma Instrument, the ratio of trace velocity fluctuations to the magnetic fluctuations (in Alfvén units), which is termed the Alfvén ratio, can be calculated down to ion kinetic scales. Comparison of the measured Alfvén ratio is performed with respect to the expectation from two‐fluid magnetohydrodynamic theory for the kinetic slow wave and kinetic Alfvén wave. Moreover, the plasma data also allow normalized fluctuation amplitudes of density and magnetic field to be compared differentiating between magnetosonic‐like and kinetic Alfvén‐like turbulence. Using these two different ratios, we can rule out that the fluctuations at ion scales are dominated by magnetosonic‐like fluctuations or kinetic slow‐like fluctuations and show that they are consistent with kinetic Alfvén‐like fluctuations. This suggests that in the wave paradigm, heating in the direction of the parallel magnetic field is predominantly by the Landau damping of the kinetic Alfvén wave

The role of TcdB and TccC subunits in secretion of the photorhabdus Tcd toxin complex

The Toxin Complex (TC) is a large multi-subunit toxin encoded by a range of bacterial pathogens. The best-characterized examples are from the insect pathogens Photorhabdus, Xenorhabdus and Yersinia. They consist of three large protein subunits, designated A, B and C that assemble in a 5:1:1 stoichiometry. Oral toxicity to a range of insects means that some have the potential to be developed as pest control technology. The three subunit proteins do not encode any recognisable export sequences and as such little progress has been made in understanding their secretion. We have developed heterologous TC production and secretion models in E. coli and used them to ascribe functions to different domains of the crucial B+C sub-complex. We have determined that the B and C subunits use a secretion mechanism that is either encoded by the proteins themselves or employ an as yet undefined system common to laboratory strains of E. coli. We demonstrate that both the N-terminal domains of the B and C subunits are required for secretion of the whole complex. We propose a model whereby the N-terminus of the C-subunit toxin exports the B+C sub-complex across the inner membrane while that of the B-subunit allows passage across the outer membrane. We also demonstrate that even in the absence of the B-subunit, that the C-subunit can also facilitate secretion of the larger A-subunit. The recognition of this novel export system is likely to be of importance to future protein secretion studies. Finally, the identification of homologues of B and C subunits in diverse bacterial pathogens, including Burkholderia and Pseudomonas, suggests that these toxins are likely to be important in a range of different hosts, including man

In situ evidence for the structure of the magnetic null in a 3D reconnection event in the Earth's magnetotail

Magnetic reconnection is one of the most important processes in astrophysical, space and laboratory plasmas. Identifying the structure around the point at which the magnetic field lines break and subsequently reform, known as the magnetic null point, is crucial to improving our understanding reconnection. But owing to the inherently three-dimensional nature of this process, magnetic nulls are only detectable through measurements obtained simultaneously from at least four points in space. Using data collected by the four spacecraft of the Cluster constellation as they traversed a diffusion region in the Earth's magnetotail on 15 September, 2001, we report here the first in situ evidence for the structure of an isolated magnetic null. The results indicate that it has a positive-spiral structure whose spatial extent is of the same order as the local ion inertial length scale, suggesting that the Hall effect could play an important role in 3D reconnection dynamics.Comment: 14 pages, 4 figure