PigBiobank: a valuable resource for understanding genetic and biological mechanisms of diverse complex traits in pigs

© The Author(s) 2023. Published by Oxford University Press on behalf of Nucleic Acids Research. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact [email protected] fully unlock the potential of pigs as both agricultural species for animal-based protein food and biomedical models for human biology and disease, a comprehensive understanding of molecular and cellular mechanisms underlying various complex phenotypes in pigs and how the findings can be translated to other species, especially humans, are urgently needed. Here, within the Farm animal Genotype-Tissue Expression (FarmGTEx) project, we build the PigBiobank (http://pigbiobank.farmgtex.org) to systematically investigate the relationships among genomic variants, regulatory elements, genes, molecular networks, tissues and complex traits in pigs. This first version of the PigBiobank curates 71 885 pigs with both genotypes and phenotypes from over 100 pig breeds worldwide, covering 264 distinct complex traits. The PigBiobank has the following functions: (i) imputed sequence-based genotype-phenotype associations via a standardized and uniform pipeline, (ii) molecular and cellular mechanisms underlying trait-associations via integrating multi-omics data, (iii) cross-species gene mapping of complex traits via transcriptome-wide association studies, and (iv) high-quality results display and visualization. The PigBiobank will be updated timely with the development of the FarmGTEx-PigGTEx project, serving as an open-access and easy-to-use resource for genetically and biologically dissecting complex traits in pigs and translating the findings to other species.National Natural Science Foundation of China [32022078]; National Key R&D Program of China [2022YFF1000900]; Local Innovative and Research Teams Project of Guangdong Province [2019BT02N630]; China Agriculture Research System [CARS-35]. Funding for open access charge: National Natural Science Foundation of China [32022078].Peer reviewe

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Two-dimensional circular platinum nanodendrites (~13 nm thick, up to 138.8 nm in diameter) were synthesized by chemical reduction of platinum complexes with ascorbic acid in the presence of block copolymer and pre-formed seeds. The nanodendrites exhibit improved performance toward the oxygen reduction reaction and methanol oxidation reaction compared with platinum black. Keywords: Two-dimensional, Circular Pt nanodendrites, Oxygen reduction reaction, Methanol oxidation reactio

Intermetallic ferric nickel silicide alloy derived from magadiite by magnesiothermic reaction as bifunctional electrocatalyst for overall water splitting

As the cleanest energy source, hydrogen energy is regarded as the most promising fuel. Water electrolysis, as the primary means of hydrogen production, has constantly been the focus of attention in the energy conversion field. Developing eco-friendly, cheap, safe and efficient catalysts for electrochemical water splitting (EWS) is the key challenge. Herein, the intermetallic silicide alloy is first synthesized via a facile magnesiothermic reduction and employed as bifunctional electrocatalysts for EWS. Ferric-nickel silicide (denoted as FeNiSi) alloy is designed and shows a good electrocatalytic performance for EWS. The lattice distortions of FeNiSi enhance the electrocatalytic activity. Besides, the porous structure affords more active sites and improves the reaction kinetics. As a consequence, FeNiSi delivers an excellent performance with overpotential of 308 mV for oxygen evolution reaction (OER) and 386 mV for hydrogen evolution reaction (HER) at 10 mA·cm−2 in 1 M KOH. The stability structure of intermetallic silicide achieves an outstanding durability with an unchanged potential of 1.66 V for overall water splitting at 10 mA·cm−2 for 15 h. This work not only provides a facile method for the synthesis of intermetallic silicide with considerable porous structures, but also develops the potential of intermetallic silicide alloy as bifunctional electrocatalysts for EWS, which opens up a new avenue for the design and application of intermetallic silicide alloy

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We report the synthesis of β-palladium hydride nanodendrites (PdH0.33 NDs). The uniform PdH0.33 NDs are 36.3 ± 5.0 nm in diameter and selectively expose (111) planes decorated with (221) and (331) high-indexed steps. The PdH0.33 NDs show a high mass activity of 0.719 A/mgPd at 0.9 V (vs. reversible hydrogen electrode-RHE) toward alkaline oxygen reduction reaction (ORR), which is 3.7 and 6.3 times that of commercial Pt/C and house-made Pd/C, respectively. This study exemplifies the possibility of using special morphology and lattice H to modify the strain and electronic effect of metal for the optimization of functionalities. Keywords: Palladium hydride, Nanodendrites, Oxygen reduction reaction, Oxygen adsorption energ

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To achieve efficient conversion of renewable energy sources through water splitting, low-cost, earth-abundant, and robust electrocatalysts for the oxygen evolution reaction (OER) and hydrogen evolution reaction (HER) are required. Herein, vertically aligned oxygenated-CoS₂–MoS₂ (O-CoMoS) heteronanosheets grown on flexible carbon fiber cloth as bifunctional electrocatalysts have been produced by use of the Anderson-type (NH₄)₄[Co^IIMo₆O₂₄H₆]·6H₂O polyoxometalate as bimetal precursor. In comparison to different O-FeMoS, O-NiMoS, and MoS₂ nanosheet arrays, the O-CoMoS heteronanosheet array exhibited low overpotentials of 97 and 272 mV to reach a current density of 10 mA cm^–2 in alkaline solution for the HER and OER, respectively. Assembled as an electrolyzer for overall water splitting, O-CoMoS heteronanosheets as both the anode and cathode deliver a current density of 10 mA cm^–2 at a quite low cell voltage of 1.6 V. This O-CoMoS architecture is highly advantageous for a disordered structure, exposure of active heterointerfaces, a “highway” of charge transport on two-dimensional conductive channels, and abundant active catalytic sites from the synergistic effect of the heterostructures, accomplishing a dramatically enhanced performance for the OER, HER, and overall water splitting. This work represents a feasible strategy to explore efficient and stable bifunctional bimetal sulfide electrocatalysts for renewable energy applications

Vertically Aligned Oxygenated-CoS₂–MoS₂ Heteronanosheet Architecture from Polyoxometalate for Efficient and Stable Overall Water Splitting

To achieve efficient conversion of renewable energy sources through water splitting, low-cost, earth-abundant, and robust electrocatalysts for the oxygen evolution reaction (OER) and hydrogen evolution reaction (HER) are required. Herein, vertically aligned oxygenated-CoS₂–MoS₂ (O-CoMoS) heteronanosheets grown on flexible carbon fiber cloth as bifunctional electrocatalysts have been produced by use of the Anderson-type (NH₄)₄[Co^IIMo₆O₂₄H₆]·6H₂O polyoxometalate as bimetal precursor. In comparison to different O-FeMoS, O-NiMoS, and MoS₂ nanosheet arrays, the O-CoMoS heteronanosheet array exhibited low overpotentials of 97 and 272 mV to reach a current density of 10 mA cm^–2 in alkaline solution for the HER and OER, respectively. Assembled as an electrolyzer for overall water splitting, O-CoMoS heteronanosheets as both the anode and cathode deliver a current density of 10 mA cm^–2 at a quite low cell voltage of 1.6 V. This O-CoMoS architecture is highly advantageous for a disordered structure, exposure of active heterointerfaces, a “highway” of charge transport on two-dimensional conductive channels, and abundant active catalytic sites from the synergistic effect of the heterostructures, accomplishing a dramatically enhanced performance for the OER, HER, and overall water splitting. This work represents a feasible strategy to explore efficient and stable bifunctional bimetal sulfide electrocatalysts for renewable energy applications