2,540 research outputs found

    Functional Integral Approach to the Single Impurity Anderson Model

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    Recently, a functional integral representation was proposed by Weller (Weller, W.: phys.~stat.~sol.~(b) {\bf 162}, 251 (1990)), in which the fermionic fields strictly satisfy the constraint of no double occupancy at each lattice site. This is achieved by introducing spin dependent Bose fields. The functional integral method is applied to the single impurity Anderson model both in the Kondo and mixed-valence regime. The f-electron Green's function and susceptibility are calculated using an Ising-like representation for the Bose fields. We discuss the difficulty to extract a spectral function from the knowledge of the imaginary time Green's function. The results are compared with NCA calculations.Comment: 11 pages, LaTeX, figures upon request, preprint No. 93/10/

    Unitary relation between a harmonic oscillator of time-dependent frequency and a simple harmonic oscillator with and without an inverse-square potential

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    The unitary operator which transforms a harmonic oscillator system of time-dependent frequency into that of a simple harmonic oscillator of different time-scale is found, with and without an inverse-square potential. It is shown that for both cases, this operator can be used in finding complete sets of wave functions of a generalized harmonic oscillator system from the well-known sets of the simple harmonic oscillator. Exact invariants of the time-dependent systems can also be obtained from the constant Hamiltonians of unit mass and frequency by making use of this unitary transformation. The geometric phases for the wave functions of a generalized harmonic oscillator with an inverse-square potential are given.Comment: Phys. Rev. A (Brief Report), in pres

    Consistent alleviation of abiotic stress with silicon addition: a meta-analysis

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    1. Hundreds of single species studies have demonstrated the facility of silicon (Si) to alleviate diverse abiotic stresses in plants. Understanding of the mechanisms of Si-mediated stress alleviation is progressing, and several reviews have brought information together. A quantitative assessment of the alleviative capacity of Si, however, which could elucidate plant Si function more broadly, was lacking. 2. We combined the results of 145 experiments, predominantly on agricultural species, in a meta-analysis to statistically assess the responses of stressed plants to Si supply across multiple plant families and abiotic stresses. We interrogated our database to determine whether stressed plants increased in dry mass and net assimilation rate, oxidative stress markers were reduced, antioxidant responses were increased and whether element uptake showed consistent changes when supplied with Si. 3. We demonstrated that across plant families and stress types, Si increases dry weight, assimilation rate and chlorophyll biosynthesis and alleviates oxidative damage in stressed plants. In general, results indicated that plant family (as a proxy for accumulator type) and stress type had significant explanatory power for variation in responses. The consistent reduction in oxidative damage was not mirrored by consistent increases in antioxidant production, indicative of the several different stress alleviation mechanisms in which Si is involved. Silicon addition increased K in shoots, decreased As and Cd in roots and Na and Cd in shoots. Silicon addition did not affect Al, Ca or Mn concentration in shoots and roots of stressed plants. Plants had significantly lower concentrations of Si accumulated in shoots but not in roots when stressed. 4. Meta-analyses showed consistent alleviation by Si of oxidative damage caused by a range of abiotic stresses across diverse species. Our findings indicate that Si is likely to be a useful fertilizer for many crops facing a spectrum of abiotic stresses. Similarities in responses across families provide strong support for a role of Si in the alleviation of abiotic stress in natural systems, where it has barely been explored. We suggest this role may become more important under a changing climate and more experiments using non-agricultural species are now needed

    Superfluidity vs Bose-Einstein condensation in a Bose gas with disorder

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    We investigate the phenomenon of Bose-Einstein condensation and superfluidity in a Bose gas at zero temperature with disorder. By using the Diffusion Monte-Carlo method we calculate the superfluid and the condensate fraction of the system as a function of density and strength of disorder. In the regime of weak disorder we find agreement with the analytical results obtained within the Bogoliubov model. For strong disorder the system enters an unusual regime where the superfluid fraction is smaller than the condensate fraction.Comment: 4 pages, 4 Postscript figure

    Solidification behavior of intensively sheared hypoeutectic Al-Si alloy liquid

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    The official published version of this article can be found at the link below.The effect of the processing temperature on the microstructural and mechanical properties of Al-Si (hypoeutectic) alloy solidified from intensively sheared liquid metal has been investigated systematically. Intensive shearing gives a significant refinement in grain size and intermetallic particle size. It also is observed that the morphology of intermetallics, defect bands, and microscopic defects in high-pressure die cast components are affected by intensive shearing the liquid metal. We attempt to discuss the possible mechanism for these effects.Funded by the EPSRC

    Molecular cytogenetic aberrations in patients with multiple myeloma studied by interphase fluorescence in situ hybridization

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    Background: Multiple myeloma (MM) is an incurable hematological disorder characterized by the accumulation of malignant plasma cells within the bone marrow (BM). The clinical heterogeneity of MM is dictated by the cytogenetic aberrations present in the clonal plasma cells (PCs). Cytogenetic studies in MM are hampered by the hypoproliferative nature of plasma cells in MM. Therefore, fluorescence in situ hybridization (FISH) analysis combined with magnetic-activated cell sorting (MACS) is an attractive alternative for evaluation of numerical and structural chromosomal changes in MM. Methods: Interphase FISH studies with three different specific probes for the regions containing 13q14.3 (D13S319), 14q32 (IGHC/IGHV) and 1q12(CEP1 ) were performed in 48 MM patients. Interphase FISH studies with LSI IGH/CCND1, LSI IGH/FGFR3, and LSI IGH/MAF probes were used to detect t(11;14)(q13;q32), t(4;14)(p16;q32), and t(14;16)(q32;q23) in patients with 14q32 rearrangement. Results: Molecular cytogenetic aberrations were found in 40 (83.3%) of the 48 MM patients. 13 patients (27.1%) simultaneously had 13q deletion/monosomy 13 [del(13q14)], illegitimate IGH rearrangement and chromosome 1 abnormality. Del(13q14) was detected in 21 cases (43.7%), and illegitimate IGH rearrangements in 29 (60.4%) including 6 with t(11;14) and 5 with t(4;14). None of 9 patients with illegitimate IGH rearrangements and without t(11;14) or t(4;14) we detected had t(14;16) (q32;q23). 24 of the 48 MM patients (50%) had chromosome 1 abnormalities. Among 21 patients with del(13q14), 15 patients had Amp1q12;16 had IgH rearrangements. Whereas, among 27 cases without del(13q14), 8 had Amp1q12; 13 had IgH rearrangements. There was a strong association between del(13q14) and Amp1q12(c2 = 8.26, Ρ€ < 0.01), and between del(13q14) and IgH rearrangement(c2 = 3.88, p < 0.05). Conclusion: 13q deletion/monosomy 13, IGH rearrangement and chromosome 1 abnormality are frequent in MM. They are not randomly distributed, but strongly interconnected. Interphase FISH technique combined with MACS using CD138-specific antibody is a highly sensitive technique at detecting molecular cytogenetic aberrations in MM.ОбоснованиС: мноТСствСнная ΠΌΠΈΠ΅Π»ΠΎΠΌΠ° (MM) β€” Π½Π΅ΠΈΠ·Π»Π΅Ρ‡ΠΈΠΌΠΎΠ΅ гСматологичСскоС Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠ΅, Ρ…Π°Ρ€Π°ΠΊΡ‚Π΅Ρ€ΠΈΠ·ΠΈΡ€ΡƒΡŽΡ‰Π΅Π΅ΡΡ Π½Π°ΠΊΠΎΠΏΠ»Π΅Π½ΠΈΠ΅ΠΌ злокачСствСнных плазматичСских ΠΊΠ»Π΅Ρ‚ΠΎΠΊ Π² костном ΠΌΠΎΠ·Π³Π΅ (КM). ΠšΠ»ΠΈΠ½ΠΈΡ‡Π΅ΡΠΊΠ°Ρ Π³Π΅Ρ‚Π΅Ρ€ΠΎΠ³Π΅Π½Π½ΠΎΡΡ‚ΡŒ MM опрСдСляСтся цитогСнСтичСскими абСррациями, ΠΏΡ€ΠΈΡΡƒΡ‚ΡΡ‚Π²ΡƒΡŽΡ‰ΠΈΠΌΠΈ Π² ΠΊΠ»ΠΎΠ½Π΅ плазматичСских ΠΊΠ»Π΅Ρ‚ΠΎΠΊ (ПК). ЦитогСнСтичСскиС исслСдования MM ослоТнСны Π³ΠΈΠΏΠΎΠΏΡ€ΠΎΠ»ΠΈΡ„Π΅Ρ€Π°Ρ‚ΠΈΠ²Π½Ρ‹ΠΌΠΈ особСнностями ПК. Π’ связи с этим флуорСсцСнтная гибридизация in situ (FISH) Π² ΠΊΠΎΠΌΠ±ΠΈΠ½Π°Ρ†ΠΈΠΈ с сортировкой ΠΊΠ»Π΅Ρ‚ΠΎΠΊ, Π°ΠΊΡ‚ΠΈΠ²ΠΈΡ€ΠΎΠ²Π°Π½Π½Ρ‹Ρ… ΠΌΠ°Π³Π½ΠΈΡ‚Π½Ρ‹ΠΌΠΈ полями (MACS) прСдставляСтся достойной Π°Π»ΡŒΡ‚Π΅Ρ€Π½Π°Ρ‚ΠΈΠ²ΠΎΠΉ ΠΌΠ΅Ρ‚ΠΎΠ΄Π°ΠΌ ΠΎΡ†Π΅Π½ΠΊΠΈ Ρ‚ΠΎΡ‡Π΅Ρ‡Π½Ρ‹Ρ… ΠΈ структурных ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠΉ хромосом ΠΏΡ€ΠΈ MM. ΠœΠ΅Ρ‚ΠΎΠ΄Ρ‹: ΠΈΠ½Ρ‚Π΅Ρ€Ρ„Π°Π·Π½Ρ‹Π΅ исслСдования ΠΌΠ΅Ρ‚ΠΎΠ΄ΠΎΠΌ FISH с использованиСм Ρ‚Ρ€Π΅Ρ… Ρ€Π°Π·Π»ΠΈΡ‡Π½Ρ‹Ρ… спСцифичСских Π·ΠΎΠ½Π΄ΠΎΠ² для участков, содСрТащих 13q14.3 (D13S319), 14q32 (IGHC/IGHV) ΠΈ 1q12(CEP1), ΠΏΡ€ΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΈ Ρƒ 48 Π±ΠΎΠ»ΡŒΠ½Ρ‹Ρ… с MM. Π˜Π½Ρ‚Π΅Ρ€Ρ„Π°Π·Π½Ρ‹Π΅ исслСдования ΠΌΠ΅Ρ‚ΠΎΠ΄ΠΎΠΌ FISH с использованиСм Π·ΠΎΠ½Π΄ΠΎΠ² LSI IGH/CCND1, LSI IGH/FGFR3 ΠΈ LSI IGH/MAF примСняли для Π΄Π΅Ρ‚Π΅ΠΊΡ†ΠΈΠΈ t(11;14)(q13;q32), t(4;14)(p16;q32), ΠΈ t(14;16)(q32;q23) Ρƒ ΠΏΠ°Ρ†ΠΈΠ΅Π½Ρ‚ΠΎΠ² с пСрСстройкой 14q32. Π Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Ρ‹: молСкулярныС цитогСнСтичСскиС Π°Π±Π΅Ρ€Ρ€Π°Ρ†ΠΈΠΈ выявляли Ρƒ 40 (83,3%) ΠΈΠ· 48 Π±ΠΎΠ»ΡŒΠ½Ρ‹Ρ… с MM. Π£ 13 ΠΏΠ°Ρ†ΠΈΠ΅Π½Ρ‚ΠΎΠ² (27,1%) ΠΎΠ΄Π½ΠΎΠ²Ρ€Π΅ΠΌΠ΅Π½Π½ΠΎ ΠΎΠΏΡ€Π΅Π΄Π΅Π»Π΅Π½Ρ‹ 13q дСлСция/моносомия 13 [del(13q14)], аномальная пСрСстройка IGH ΠΈ аномалия хромосомы 1. Del(13q14) Π΄Π΅Ρ‚Π΅ΠΊΡ‚ΠΈΡ€ΠΎΠ²Π°Π»ΠΈ Π² 21 случаС (43,7%), Π° Π°Π½ΠΎΠΌΠ°Π»ΡŒΠ½Ρ‹Π΅ пСрСстройки IGH β€” Π² 29 (60,4%), Π² Ρ‚ΠΎΠΌ числС Ρƒ 6 ΠΏΠ°Ρ†ΠΈΠ΅Π½Ρ‚ΠΎΠ² с t(11;14) ΠΈ 5 с t(4;14). Ни Ρƒ ΠΎΠ΄Π½ΠΎΠ³ΠΎ ΠΈΠ· 9 Π±ΠΎΠ»ΡŒΠ½Ρ‹Ρ… с Π°Π½ΠΎΠΌΠ°Π»ΡŒΠ½Ρ‹ΠΌΠΈ пСрСстройками IGH ΠΈ Π±Π΅Π· t(11;14) ΠΈΠ»ΠΈ t(4;14) Π½Π΅ выявляли Ρ‚Ρ€Π°Π½ΡΠ»ΠΎΠΊΠ°Ρ†ΠΈΡŽ t(14;16) (q32;q23). Π£ 24 ΠΈΠ· 48 ΠΏΠ°Ρ†ΠΈΠ΅Π½Ρ‚ΠΎΠ² с MM (50%) опрСдСляли Π°Π½ΠΎΠΌΠ°Π»ΠΈΠΈ хромосомы 1. Π’ Π³Ρ€ΡƒΠΏΠΏΠ΅ ΠΈΠ· 21 Π±ΠΎΠ»ΡŒΠ½Ρ‹Ρ… с del(13q14) Π² 15 случаях имСлись пСрСстройки IgH Amp1q12;16. Π’ Ρ‚ΠΎ ΠΆΠ΅ врСмя ΠΈΠ· 27 случаСв Π±Π΅Π· del(13q14) Ρƒ 8 ΡΠΎΠ΄Π΅Ρ€ΠΆΠ°Π»ΠΈΡΡŒ Amp1q12; Π² 13 случаях ΠΎΡ‚ΠΌΠ΅Ρ‡Π°Π»ΠΈ пСрСстройки IgH. ВыявлСна взаимосвязь ΠΌΠ΅ΠΆΠ΄Ρƒ del(13q14) ΠΈ Amp1q12(Ο‡2 = 8,26, p < 0,01) ΠΈ ΠΌΠ΅ΠΆΠ΄Ρƒ del(13q14) ΠΈ пСрСстройками IgH (Ο‡2 = 3,88, p < 0,05). Π’Ρ‹Π²ΠΎΠ΄Ρ‹: 13q Π΄Π΅Π»Π΅Ρ†ΠΈΡŽ/моносомию 13, пСрСстройку IGH ΠΈ аномалию хромосомы 1 часто ΠΎΡ‚ΠΌΠ΅Ρ‡Π°ΡŽΡ‚ ΠΏΡ€ΠΈ MM, ΠΏΡ€ΠΈΡ‡Π΅ΠΌ ΠΈΡ… распрСдСлСниС Π½Π΅ случайно ΠΈ тСсно взаимосвязано. Π˜Π½Ρ‚Π΅Ρ€Ρ„Π°Π·Π½Ρ‹ΠΉ Π°Π½Π°Π»ΠΈΠ· FISH Π² ΠΊΠΎΠΌΠ±ΠΈΠ½Π°Ρ†ΠΈΠΈ с MACS с использованиСм CD138-спСцифичных Π°Π½Ρ‚ΠΈΡ‚Π΅Π» являСтся Π²Ρ‹ΡΠΎΠΊΠΎΡ‡ΡƒΠ²ΡΡ‚Π²ΠΈΡ‚Π΅Π»ΡŒΠ½Ρ‹ΠΌ ΠΌΠ΅Ρ‚ΠΎΠ΄ΠΎΠΌ Π΄Π΅Ρ‚Π΅ΠΊΡ†ΠΈΠΈ молСкулярных цитогСнСтичСских Π°Π±Π΅Ρ€Ρ€Π°Ρ†ΠΈΠΉ ΠΏΡ€ΠΈ MM

    Disease survey of cereal crops in Saskatchewan in 2013

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    Non-Peer ReviewedCereal crops in Saskatchewan can suffer a number of diseases that reduce yield and quality. A disease survey was conducted in 2013 to identify pathogenic agents and assess disease severity on oat, canaryseed, barley and winter and spring wheat. Crown rust was detected at trace levels in four of 32 oat crops and the most common leaf spotting pathogens were Pyrenophora avenae and Stagnospora avenae, similar to previous years. On canaryseed, Septoria triseti was observed from plating of leaf samples and appeared to be highest in west-central SK and lowest in the north-east. Fusarium avenaceum was identified from plating of seeds in four of 26 crops, but only at low levels. In barley, only two crops were affected by stripe rust, but leaf spots symptoms observed on most crops, most commonly caused by Cochliobolus sativus and Pyrenophora teres; Septoria passerinii was identified in a few samples. Severe stripe rust infection was observed in seven of 89 winter wheat crops, but 60 crops were stripe rust-free. In winter wheat fusarium head blight was generally low in most regions of SK, except near Outlook, where severity was much higher. In spring wheat, stripe rust infection was observed in eight of 17 crops and was severe in one crop

    Numerical Simulation and Experimental Study on the Interface Bonding of Stainless Steel Clad Plate

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    The rolling temperature and rate of thickness reduction directly affect the interface bonding quality, mechanical properties and microstructure of stainless steel clad plate. In order to obtain reasonable rolling process parameters, the multi-pass rolling processes of Q345R/316L stainless steel clad plate were simulated by the DEFORM software package. The distributions of stress, strain, and microstructure fields of the clad plate at different rolling temperatures and reduction rates were investigated. The bonding state of the interface was determined and the change rules governing the grain size of the rolled substrate layer also were analyzed. Vacuum hot-rolling tests were carried out to characterize the microstructure and mechanical properties. It was found that the higher the rolling temperature, the lower was the reduction rate needed to realize the interface bonding. However, too high temperatures produce a higher fraction of coarse grains, which affects the overall mechanical properties of the clad plate. It was concluded from the tests and numerical results that rolling temperature of 1150Β°C and reduction rate exceeding 50%, stainless allow one to produce steel clad plates with high interface bonding quality and excellent microstructure.Показано, Ρ‡Ρ‚ΠΎ Ρ‚Π΅ΠΌΠΏΠ΅Ρ€Π°Ρ‚ΡƒΡ€Π° ΠΏΡ€ΠΎΠΊΠ°Ρ‚ΠΊΠΈ ΠΈ ΡΡ‚Π΅ΠΏΠ΅Π½ΡŒ обТатия ΠΎΠΊΠ°Π·Ρ‹Π²Π°ΡŽΡ‚ влияниС Π½Π° силу сцСплСния Π½Π° повСрхности Ρ€Π°Π·Π΄Π΅Π»Π°, мСханичСскиС свойства ΠΈ микроструктуру пластины, ΠΏΠ»Π°ΠΊΠΈΡ€ΠΎΠ²Π°Π½Π½ΠΎΠΉ Π½Π΅Ρ€ΠΆΠ°Π²Π΅ΡŽΡ‰Π΅ΠΉ ΡΡ‚Π°Π»ΡŒΡŽ. ΠŸΡ€ΠΎΡ†Π΅ΡΡ ΠΏΡ€ΠΎΠΊΠ°Ρ‚ΠΊΠΈ Π·Π° Ρ‡Π΅Ρ‚Ρ‹Ρ€Π΅ пропуска для пластины, ΠΏΠ»Π°ΠΊΠΈΡ€ΠΎΠ²Π°Π½Π½ΠΎΠΉ Π½Π΅Ρ€ΠΆΠ°Π²Π΅ΡŽΡ‰Π΅ΠΉ ΡΡ‚Π°Π»ΡŒΡŽ Q345R/316L, ΠΌΠΎΠ΄Π΅Π»ΠΈΡ€ΠΎΠ²Π°Π»ΠΈ с ΠΏΠΎΠΌΠΎΡ‰ΡŒΡŽ ΠΏΡ€ΠΎΠ³Ρ€Π°ΠΌΠΌΡ‹ DEFORM, Ρ‡Ρ‚ΠΎ ΠΏΠΎΠ·Π²ΠΎΠ»ΠΈΠ»ΠΎ Ρ€Π°ΡΡΡ‡ΠΈΡ‚Π°Ρ‚ΡŒ Π΅Π³ΠΎ Ρ€Π°Π±ΠΎΡ‡ΠΈΠ΅ ΠΏΠ°Ρ€Π°ΠΌΠ΅Ρ‚Ρ€Ρ‹. ИсслСдовано распрСдСлСниС ΠΏΠΎΠ»Π΅ΠΉ напряТСний, Π΄Π΅Ρ„ΠΎΡ€ΠΌΠ°Ρ†ΠΈΠΉ ΠΈ микроструктуры пластины ΠΏΡ€ΠΈ Ρ€Π°Π·Π»ΠΈΡ‡Π½ΠΎΠΉ Ρ‚Π΅ΠΌΠΏΠ΅Ρ€Π°Ρ‚ΡƒΡ€Π΅ ΠΏΡ€ΠΎΠΊΠ°Ρ‚ΠΊΠΈ ΠΈ стСпСни обТатия. ΠžΠΏΡ€Π΅Π΄Π΅Π»Π΅Π½Π° сила сцСплСния Π½Π° повСрхности Ρ€Π°Π·Π΄Π΅Π»Π°, ΠΏΡ€ΠΎΠ°Π½Π°Π»ΠΈΠ·ΠΈΡ€ΠΎΠ²Π°Π½ грануломСтричСский состав ΠΊΠ°Ρ‚Π°Π½ΠΎΠ³ΠΎ подслоя ΠΏΡ€ΠΈ Ρ€Π°Π·Π»ΠΈΡ‡Π½Ρ‹Ρ… Ρ‚Π΅ΠΌΠΏΠ΅Ρ€Π°Ρ‚ΡƒΡ€Π°Ρ…. ΠŸΡ€ΠΎΠ²Π΅Π΄Π΅Π½Ρ‹ испытания ΠΎΠ±Ρ€Π°Π·Ρ†ΠΎΠ², ΠΏΠΎΠ»ΡƒΡ‡Π΅Π½Π½Ρ‹Ρ… горячСй Π²Π°ΠΊΡƒΡƒΠΌΠ½ΠΎΠΉ ΠΏΡ€ΠΎΠΊΠ°Ρ‚ΠΊΠΎΠΉ, для ΠΎΡ†Π΅Π½ΠΊΠΈ микроструктуры ΠΈ мСханичСских свойств. УстановлСно, Ρ‡Ρ‚ΠΎ Ρ‡Π΅ΠΌ Π²Ρ‹ΡˆΠ΅ Ρ‚Π΅ΠΌΠΏΠ΅Ρ€Π°Ρ‚ΡƒΡ€Π° ΠΏΡ€ΠΎΠΊΠ°Ρ‚ΠΊΠΈ, Ρ‚Π΅ΠΌ Π½ΠΈΠΆΠ΅ ΡΡ‚Π΅ΠΏΠ΅Π½ΡŒ обТатия, нСобходимая для обСспСчСния сцСплСния Π½Π° повСрхности Ρ€Π°Π·Π΄Π΅Π»Π°. Однако Π±ΠΎΠ»Π΅Π΅ высокиС Ρ‚Π΅ΠΌΠΏΠ΅Ρ€Π°Ρ‚ΡƒΡ€Ρ‹ Π²Ρ‹Π·Ρ‹Π²Π°ΡŽΡ‚ ΡƒΠ²Π΅Π»ΠΈΡ‡Π΅Π½ΠΈΠ΅ Π΄ΠΎΠ»ΠΈ Π³Ρ€ΡƒΠ±Ρ‹Ρ… Π·Π΅Ρ€Π΅Π½, Ρ‡Ρ‚ΠΎ ΠΎΠΊΠ°Π·Ρ‹Π²Π°Π΅Ρ‚ влияниС Π½Π° мСханичСскиС свойства пластины. Π­ΠΊΡΠΏΠ΅Ρ€ΠΈΠΌΠ΅Π½Ρ‚Π°Π»ΡŒΠ½ΠΎ ΠΈ числСнно ΠΏΠΎΠΊΠ°Π·Π°Π½ΠΎ, Ρ‡Ρ‚ΠΎ Ρ‚Π΅ΠΌΠΏΠ΅Ρ€Π°Ρ‚ΡƒΡ€Π° ΠΏΡ€ΠΎΠΊΠ°Ρ‚ΠΊΠΈ Π² 1150Β°Π‘ ΠΈ ΡΡ‚Π΅ΠΏΠ΅Π½ΡŒ обТатия Π±ΠΎΠ»Π΅Π΅ 50% ΠΎΠ±Π΅ΡΠΏΠ΅Ρ‡ΠΈΠ²Π°ΡŽΡ‚ Π½Π΅ΠΎΠ±Ρ…ΠΎΠ΄ΠΈΠΌΡƒΡŽ силу сцСплСния ΠΈ ΠΊΠ°Ρ‡Π΅ΡΡ‚Π²Π΅Π½Π½ΡƒΡŽ микроструктуру ΠΏΠ»Π°ΠΊΠΈΡ€ΠΎΠ²Π°Π½Π½ΠΎΠΉ пластин

    Ultrasound Super-Resolution Imaging for the Differential Diagnosis of Thyroid Nodules: A Pilot Study

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    Objective: Ultrasound imaging provides a fast and safe examination of thyroid nodules. Recently, the introduction of superresolution imaging technique shows the capability of breaking the Ultrasound diffraction limit in imaging the micro-vessels. The aim of this study was to evaluate its feasibility and value for the differentiation of thyroid nodules. Methods: In this study, B-mode, contrast-enhanced ultrasound, and color Doppler flow imaging examinations were performed on thyroid nodules in 24 patients. Super-resolution imaging was performed to visualize the microvasculature with finer details. Microvascular flow rate (MFR) and micro-vessel density (MVD) within thyroid nodules were computed. The MFR and MVD were used to differentiate the benign and malignant thyroid nodules with pathological results as a gold standard. Results: Super-resolution imaging (SRI) technique can be successfully applied on human thyroid nodules to visualize the microvasculature with finer details and obtain the useful clinical information MVD and MFR to help differential diagnosis. The results suggested that the mean value of the MFR within benign thyroid nodule was 16.76 Β± 6.82 mm/s whereas that within malignant thyroid was 9.86 Β± 4.54 mm/s. The mean value of the MVD within benign thyroid was 0.78 while the value for malignant thyroid region was 0.59. MFR and MVD within the benign thyroid nodules were significantly higher than those within the malignant thyroid nodules respectively (p < 0.01). Conclusions: This study demonstrates the feasibility of ultrasound super-resolution imaging to show micro-vessels of human thyroid nodules via a clinical ultrasound platform. The important imaging markers, such as MVD and MFR, can be derived from SRI to provide more useful clinical information. It has the potential to be a new tool for aiding differential diagnosis of thyroid nodules
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