Magnetothermoelectric DC conductivities from holography models with hyperscaling factor in Lifshitz spacetime

We investigate an Einstein-Maxwell-Dilaton-Axion holographic model and obtain two branches of a charged black hole solution with a dynamic exponent and a hyperscaling violation factor when a magnetic field presents. The magnetothermoelectric DC conductivities are then calculated in terms of horizon data by means of holographic principle. We find that linear temperature dependence resistivity and quadratic temperature dependence inverse Hall angle can be achieved in our model. The well-known anomalous temperature scaling of the Nernst signal and the Seebeck coefficient of cuprate strange metals are also discussed.Comment: 1+23 pages, 4 figures, references adde

Whole transcriptome sequencing identifies tumor-specific mutations in human oral squamous cell carcinoma

Background: The accumulation of somatic mutations in genes and molecular pathways is a major factor in the evolution of oral squamous cell carcinoma (OSCC), which sparks studies to identify somatic mutations with clinical potentials. Recently, massively parallel sequencing technique has started to revolutionize biomedical studies, due to the rapid increase in its throughput and drop in cost. Hence sequencing of whole transcriptome (RNA-Seq) becomes a superior approach in cancer studies, which enables the detection of somatic mutations and accurate measurement of gene expression simultaneously. Methods: We used RNA-Seq data from tumor and matched normal samples to investigate somatic mutation spectrum in OSCC. Results: By applying a sophisticated bioinformatic pipeline, we interrogated two tumor samples and their matched normal tissues and identified 70,472 tumor somatic mutations in protein-coding regions. We further identified 515 significantly mutated genes (SMGs) and 156 tumor-specific disruptive genes (TDGs), with six genes in both sets, including ANKRA2, GTF2H5, STOML1, NUP37, PPP1R26, and TAF1L. Pathway analysis suggested that SMGs were enriched in cell adhesion pathways, which are frequently indicated in tumor development. We also found that SMGs tend to be differentially expressed between tumors and normal tissues, implying a regulatory role of accumulation of genetic aberrations in these genes. Conclusions: Our finding of known tumor genes proves of the utility of RNA-Seq in mutation screening, and functional analysis of genes detected here would help understand the molecular mechanism of OSCC

Poly[[triaqua­(μ3-pyridine-2,4,6-tri­car­boxyl­ato)gadolinium(III)] monohydrate]

The title compound, {[Gd(C8H2NO6)(H2O)3]·H2O}n, was obtained in water under hydro­thermal conditions. The GdIII ions are nine-coordinated by two O and one N atoms from one pyridine-2,4,6-tricarboxyl­ate ligand, two O atoms from another ligand, one O atom from a third ligand and three coordinated water mol­ecules. Each ligand binds three metal centers. Two-dimensional layers are formed through the Gd—O bonds and the layers are linked by O—H⋯O hydrogen bonds, forming a three-dimensional network

Top Quark Forward-Backward Asymmetry and Same-Sign Top Quark Pairs

The top quark forward-backward asymmetry measured at the Tevatron collider shows a large deviation from standard model expectations. Among possible interpretations, a non-universal $Z^\prime$ model is of particular interest as it naturally predicts a top quark in the forward region of large rapidity. To reproduce the size of the asymmetry, the couplings of the $Z^\prime$ to standard model quarks must be large, inevitably leading to copious production of same-sign top quark pairs at the energies of the Large Hadron Collider (LHC). We explore the discovery potential for $tt$ and $ttj$ production in early LHC experiments at 7-8 TeV and conclude that if {\it no} $tt$ signal is observed with 1 fb$^{-1}$ of integrated luminosity, then a non-universal $Z^\prime$ alone cannot explain the Tevatron forward-backward asymmetry.Comment: Tevatron limit from same-sign tt search adde

Sexual and reproductive health correlates of polysubstance use among female adolescents who sell sex in the southwest of China

Background Substance use and adverse sexual and reproductive health (SRH) outcomes continue to be significant threats to female adolescents' health and wellbeing, particularly to these marginalized subpopulations. Our research aimed to tackle knowledge gaps regarding the prevalence of concurrent substance use including alcohol, tobacco, illicit drug among Chinese adolescent female sex workers (AFSWs), while to assess the correlates between substance use and SRH risks; the needs for comprehensive SRH services were also examined in this study. Methods A cross-sectional study enrolled 310 AFSWs aged 15-19 years by using cluster sampling method in Kunming, China. Descriptive analysis was employed to characterize the participants who were regular-alcohol users, regular-tobacco users, illicit drug users and polysubstance users. Multivariable logistic regression analysis was performed to detect the SRH correlates of regular-alcohol use, regular-tobacco use, illicit drugs and polysubstance use respectively. Results There is a high prevalence of regular-alcohol drinking (83%, 257/310) among AFSWs, with 44% (136/310) smoking cigarettes regularly and 9% using illicit drug (27/310) in the past year. In multivariate analysis, AFSWs who had middle and high school education, had higher monthly income, experienced of sexual and gender based violence (SGBV) and prior abortion, and regular-tobacco smoking were associated with increased odds of regular-alcohol drinking; engaging in unprotected sex while drunk, having STIs symptoms and using illicit drugs were significantly associated with regular-tobacco smoking; while AFSWs who had an illicit drug using- intimate partner, experienced forced sexual initiation, accessed unsafe medical providers for STIs treatment were associate with increased odds of illicit drug use. Moreover, 35% (105/298) AFSWs sought unsafe medical care for STIs treatment, or no treatment at all, among them, majority were using polysubstance (87%; 91/105). Conclusions Our findings reveal combined threats of substance use to AFSWs' SRH and wellbeing in China, this study emphasises that the coordinated efforts are needed to integrate SRH promotion and harm reduction service across sectors, and not only fragmented measures. An effective response should include an agreed framework, indicators and targets supported by political will, solid leadership and policy reform to deal with AFSWs' overlapping vulnerabilities in a systematic way

Focal Spot, Winter 1983/84

https://digitalcommons.wustl.edu/focal_spot_archives/1036/thumbnail.jp