What Do They Mean by "Health Informatics"? Health Informations Posts Compared to Program Standards

There is a lack of alignment between and within the competencies and skills required by health informatics (HI) related jobs and those present in academic curriculum frameworks. This study uses computational topic modeling for gap analysis of career needs vs. curriculum objectives. The seven AMIA-CAHIIM-accepted core knowledge domains were used to categorize a corpus of HI-related job postings (N = 475) from a major United States-based job posting website. Computational modeling-generated topics were created and then compared and matched to the seven core knowledge domains. The HI-defining core domain, representing the intersection of health, technology and social/behavioral sciences matched only 45.9% of job posting content. Therefore, the authors suggest that bidirectional communication between academia and industry is needed in order to better align educational objectives to the demands of the job market

A Novel Pipeline for Targeting Breast Cancer Patients on Twitter for Clinical Trial Recruitment

Background and Preliminary Exploration: Breast cancer is the leading form of cancer in women, estimated to reach the incidence rate of 246,660 in 2016 in the US population. Scientist have developed new therapies for mitigating the disease and side effects in recent years through conducting randomized clinical trials as the gold standard clinical research method. However, recruiting individuals into clinical trials including breast cancer patients has remained a significant challenge. Our preliminary analysis on ClinicalTrial.gov registry showed that the majority of terminated clinical trials were due to recruitment challenges. Out of 525 terminated trials on breast cancer patients registered in the database, 230 (43.8%) of the terminations happened due to low or slow accrual, 34 (6.5%) due to lack of funding, and 31 (5.9%) due to toxicity concerns. Objectives: In this study, we developed and assess a scalable framework to identify Twitter users who have breast cancer based on personal health mentions on Twitter. In fact, we are looking for “fingerprints” of patients’ health status on Twitter, a microblogging social networking service. This method could provide a new avenue for contacting potential study candidates for recruitment. Methods: We analyzed the tweets of users who were following at least one of the top 40 twitter accounts where breast cancer patients gather. The rationale behind this approach is that cancer patients are following certain Twitter accounts to access support from other patients, doctors, or healthcare institutions. Consequently, these top twitter accounts provide a central point in which to find actual patients with breast cancer. We retrieved users’ tweets from Twitter API, and processed through the framework to match cancer relevant words and phrases individually and in combinations (caner, benign, malignant, etc.), possessive terms (I, my, has, have, etc.), and supporting attributes (mass, tumor, hair loss, etc.) to determine if the user has been diagnosed with cancer. The performance of the pipeline was measured in terms of sensitivity and specificity of detecting actual breast cancer patients. Results: We retrieved 25,870,106 tweets of 40 cancer community followers on Twitter. After excluding “retweets” and non-related breast cancer messages, we selected 81,429 tweets for further processing. The developed text processing pipeline could find total of 462 tweets based on the predefined sets of rules, representing 218 unique users. Our new method of Twitter data retrieval and text processing could identify breast cancer patients with remarkable sensitivity of 88.7% and specificity of 91.0%

Temperature-Sensitive Point Selection and Thermal Error Model Adaptive Update Method of CNC Machine Tools

The thermal error of CNC machine tools can be reduced by compensation, where a thermal error model is required to provide compensation values. The thermal error model adaptive update method can correct the thermal error model by supplementing new data, which fundamentally solves the problem of model robustness. Certain problems associated with this method in temperature-sensitive point (TSP) selection and model update algorithms are investigated in this study. It was found that when the TSPs were selected frequently, the selection results may be different, that is, there was a variability problem in TSPs. Further, it was found that the variability of TSPs is mainly due to some problems with the TSP selection method, (1) the conflict between the collinearity among TSPs and the correlation of TSPs with thermal error is ignored, (2) the stability of the correlation is not considered. Then, a stable TSP selection method that can choose more stable TSPs with less variability was proposed. For the model update algorithm, this study proposed a novel regression algorithm which could effectively combine the new data with the old model. It has advantages for a model update, (1) fewer data are needed for the model update, (2) the model accuracy is greatly improved. The effectiveness of the proposed method was verified by 20 batches of thermal error measurement experiments in the real cutting state of the machine tool

Prediction of blasting mean fragment size using support vector regression combined with five optimization algorithms

The main purpose of blasting operation is to produce desired and optimum mean size rock fragments. Smaller or fine fragments cause the loss of ore during loading and transportation, whereas large or coarser fragments need to be further processed, which enhances production cost. Therefore, accurate prediction of rock fragmentation is crucial in blasting operations. Mean fragment size (MFS) is a crucial index that measures the goodness of blasting designs. Over the past decades, various models have been proposed to evaluate and predict blasting fragmentation. Among these models, artificial intelligence (AI)-based models are becoming more popular due to their outstanding prediction results for multi-influential factors. In this study, support vector regression (SVR) techniques are adopted as the basic prediction tools, and five types of optimization algorithms, i.e. grid search (GS), grey wolf optimization (GWO), particle swarm optimization (PSO), genetic algorithm (GA) and salp swarm algorithm (SSA), are implemented to improve the prediction performance and optimize the hyper-parameters. The prediction model involves 19 influential factors that constitute a comprehensive blasting MFS evaluation system based on AI techniques. Among all the models, the GWO-v-SVR-based model shows the best comprehensive performance in predicting MFS in blasting operation. Three types of mathematical indices, i.e. mean square error (MSE), coefficient of determination (R2) and variance accounted for (VAF), are utilized for evaluating the performance of different prediction models. The R2, MSE and VAF values for the training set are 0.8355, 0.00138 and 80.98, respectively, whereas 0.8353, 0.00348 and 82.41, respectively for the testing set. Finally, sensitivity analysis is performed to understand the influence of input parameters on MFS. It shows that the most sensitive factor in blasting MFS is the uniaxial compressive strength. © 2021 Institute of Rock and Soil Mechanics, Chinese Academy of Science

Self-Assembly-Directed Cancer Cell Membrane Insertion of Synthetic Analogues for Permeability Alteration

Inspired by the metamorphosis of pore-forming toxins from soluble inactive monomers to cytolytic trans-membrane assemblies, we developed self-assembly-directed membrane insertion of synthetic analogues for permeability alteration. An expanded pi-conjugation-based molecular precursor with an extremely high rigidity and a long hydrophobic length that is comparable to the hydrophobic width of plasma membrane was synthesized for membrane-inserted self-assembly. Guided by the cancer biomarker expression in vitro, the soluble precursors transform into hydrophobic monomers forming assemblies inserted into the fluid phase of the membrane exclusively. Membrane insertion of rigid synthetic analogues destroys the selective permeability of the plasma membrane gradually. It eventually leads to cancer cell death, including drug resistant cancer cells

Design and assessment of a reconfigurable behavioral assistive robot: a pilot study

IntroductionFor patients with functional motor disorders of the lower limbs due to brain damage or accidental injury, restoring the ability to stand and walk plays an important role in clinical rehabilitation. Lower limb exoskeleton robots generally require patients to convert themselves to a standing position for use, while being a wearable device with limited movement distance.MethodsThis paper proposes a reconfigurable behavioral assistive robot that integrates the functions of an exoskeleton robot and an assistive standing wheelchair through a novel mechanism. The new mechanism is based on a four-bar linkage, and through simple and stable conformal transformations, the robot can switch between exoskeleton state, sit-to-stand support state, and wheelchair state. This enables the robot to achieve the functions of assisted walking, assisted standing up, supported standing and wheelchair mobility, respectively, thereby meeting the daily activity needs of sit-to-stand transitions and gait training. The configuration transformation module controls seamless switching between different configurations through an industrial computer. Experimental protocols have been developed for wearable testing of robotic prototypes not only for healthy subjects but also for simulated hemiplegic patients.ResultsThe experimental results indicate that the gait tracking effect during robot-assisted walking is satisfactory, and there are no sudden speed changes during the assisted standing up process, providing smooth support to the wearer. Meanwhile, the activation of the main force-generating muscles of the legs and the plantar pressure decreases significantly in healthy subjects and simulated hemiplegic patients wearing the robot for assisted walking and assisted standing-up compared to the situation when the robot is not worn.DiscussionThese experimental findings demonstrate that the reconfigurable behavioral assistive robot prototype of this study is effective, reducing the muscular burden on the wearer during walking and standing up, and provide effective support for the subject's body. The experimental results objectively and comprehensively showcase the effectiveness and potential of the reconfigurable behavioral assistive robot in the realms of behavioral assistance and rehabilitation training

Looking and Listening: Audio Guided Text Recognition

Text recognition in the wild is a long-standing problem in computer vision. Driven by end-to-end deep learning, recent studies suggest vision and language processing are effective for scene text recognition. Yet, solving edit errors such as add, delete, or replace is still the main challenge for existing approaches. In fact, the content of the text and its audio are naturally corresponding to each other, i.e., a single character error may result in a clear different pronunciation. In this paper, we propose the AudioOCR, a simple yet effective probabilistic audio decoder for mel spectrogram sequence prediction to guide the scene text recognition, which only participates in the training phase and brings no extra cost during the inference stage. The underlying principle of AudioOCR can be easily applied to the existing approaches. Experiments using 7 previous scene text recognition methods on 12 existing regular, irregular, and occluded benchmarks demonstrate our proposed method can bring consistent improvement. More importantly, through our experimentation, we show that AudioOCR possesses a generalizability that extends to more challenging scenarios, including recognizing non-English text, out-of-vocabulary words, and text with various accents. Code will be available at https://github.com/wenwenyu/AudioOCR

Unraveling the Global Warming Mitigation Potential from Recycling Subway‐Related Excavated Soil and Rock in China Via Life Cycle Assessment

Many cities across China are investing in subway projects, resulting in much subway construction activity, which has experienced a surge over the past decade. The construction activities inevitably cause a dramatic quantity of subway-related excavated soil and rock (ESR). How to manage it with minimal environmental impact on our urban ecosystem remains an open question. This present study evaluates global warming potential (GWP, expressed by CO eq.) from different ESR recycling and landfilling scenarios via a life cycle assessment model based on primary field investigation combined with the LCA software database. The study results illustrate that recycling ESR can significantly reduce greenhouse gas emissions. In comparison with traditional construction materials, the scenarios found that a cumulative amount of 1.1-1.5 Mt (Million tonnes) of CO eq. emissions could have been mitigated by using ESR generated between 2010 and 2018 to produce baking-free bricks and recycled baked brick. Using cost-benefit analysis, potential economic benefits from recycled sand and baking-free bricks are found to reach 9 million USD annually. The findings of this study could provide better recycling options for ESR-related stakeholders. It is important to mention is that there still much work to be done before this recycling work can be popularized in China. This article is protected by copyright. All rights reserved. [Abstract copyright: This article is protected by copyright. All rights reserved.