34 research outputs found

    An analysis of the content of world history workbooks on a senior high school level

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    Thesis (Ed.M.)--Boston University, 1948. This item was digitized by the Internet Archive

    Intergroup contact and the potential for post-conflict reconciliation: Studies in Northern Ireland and South Africa.

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    With surveys of Protestants and Catholics in Northern Ireland, and Whites and Blacks in South Africa, this research examines how both contact quality and exposure to intergroup conflict predict attitudes, beliefs, and behaviors relevant to intergroup reconciliation. Across both studies, contact of higher quality predicted more positive intergroup attitudes, trust, more positive perceptions of outgroup intentions in working toward peace, and greater engagement in reconciliation efforts. These effects were observed when controlling for exposure to conflict-related violence in one’s neighborhood growing up, and the extent to which one has personally suffered due to the conflict. Implications of these findings for future work on intergroup contact and reconciliation efforts are discussed

    Relative stereociliary motion in a hair bundle opposes amplification at distortion frequencies

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    Direct gating of mechanoelectrical-transduction channels by mechanical force is a basic feature of hair cells that assures fast transduction and underpins the mechanical amplification of acoustic inputs. But the associated nonlinearity - the gating compliance - inevitably distorts signals. Because reducing distortion would make the ear a better detector, we sought mechanisms with that effect. Mimicking in vivo stimulation, we used stiff probes to displace individual hair bundles at physiological amplitudes and measured the coherence and phase of the relative stereociliary motions with a dual-beam differential interferometer. Although stereocilia moved coherently and in phase at the stimulus frequencies, large phase lags at the frequencies of the internally generated distortion products indicated dissipative relative motions. Tip links engaged these relative modes and decreased the coherence in both stimulated and free hair bundles. These results show that a hair bundle breaks into a highly dissipative serial arrangement of stereocilia at distortion frequencies, precluding their amplification.Comment: 33 pages in total, including the main article with one table and three figures, as well as the supplemental information that itself contains two figure

    Structure and mechanics of supporting cells in the guinea pig organ of Corti.

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    The mechanical properties of the mammalian organ of Corti determine its sensitivity to sound frequency and intensity, and the structure of supporting cells changes progressively with frequency along the cochlea. From the apex (low frequency) to the base (high frequency) of the guinea pig cochlea inner pillar cells decrease in length incrementally from 75-55 µm whilst the number of axial microtubules increases from 1,300-2,100. The respective values for outer pillar cells are 120-65 µm and 1,500-3,000. This correlates with a progressive decrease in the length of the outer hair cells from >100 µm to 20 µm. Deiters'cell bodies vary from 60-50 µm long with relatively little change in microtubule number. Their phalangeal processes reflect the lengths of outer hair cells but their microtubule numbers do not change systematically. Correlations between cell length, microtubule number and cochlear location are poor below 1 kHz. Cell stiffness was estimated from direct mechanical measurements made previously from isolated inner and outer pillar cells. We estimate that between 200 Hz and 20 kHz axial stiffness, bending stiffness and buckling limits increase, respectively,~3, 6 and 4 fold for outer pillar cells, ~2, 3 and 2.5 fold for inner pillar cells and ~7, 20 and 24 fold for the phalangeal processes of Deiters'cells. There was little change in the Deiters'cell bodies for any parameter. Compensating for effective cell length the pillar cells are likely to be considerably stiffer than Deiters'cells with buckling limits 10-40 times greater. These data show a clear relationship between cell mechanics and frequency. However, measurements from single cells alone are insufficient and they must be combined with more accurate details of how the multicellular architecture influences the mechanical properties of the whole organ

    Hair Cell Bundles: Flexoelectric Motors of the Inner Ear

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    Microvilli (stereocilia) projecting from the apex of hair cells in the inner ear are actively motile structures that feed energy into the vibration of the inner ear and enhance sensitivity to sound. The biophysical mechanism underlying the hair bundle motor is unknown. In this study, we examined a membrane flexoelectric origin for active movements in stereocilia and conclude that it is likely to be an important contributor to mechanical power output by hair bundles. We formulated a realistic biophysical model of stereocilia incorporating stereocilia dimensions, the known flexoelectric coefficient of lipid membranes, mechanical compliance, and fluid drag. Electrical power enters the stereocilia through displacement sensitive ion channels and, due to the small diameter of stereocilia, is converted to useful mechanical power output by flexoelectricity. This motor augments molecular motors associated with the mechanosensitive apparatus itself that have been described previously. The model reveals stereocilia to be highly efficient and fast flexoelectric motors that capture the energy in the extracellular electro-chemical potential of the inner ear to generate mechanical power output. The power analysis provides an explanation for the correlation between stereocilia height and the tonotopic organization of hearing organs. Further, results suggest that flexoelectricity may be essential to the exquisite sensitivity and frequency selectivity of non-mammalian hearing organs at high auditory frequencies, and may contribute to the “cochlear amplifier” in mammals

    Dynamic Analysis of Shells

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    Shell structures are indispensable in virtually every industry. However, in the design, analysis, fabrication, and maintenance of such structures, there are many pitfalls leading to various forms of disaster. The experience gained by engineers over some 200 years of disasters and brushes with disaster is expressed in the extensive archival literature, national codes, and procedural documentation found in larger companies. However, the advantage of the richness in the behavior of shells is that the way is always open for innovation. In this survey, we present a broad overview of the dynamic response of shell structures. The intention is to provide an understanding of the basic themes behind the detailed codes and stimulate, not restrict, positive innovation. Such understanding is also crucial for the correct computation of shell structures by any computer code. The physics dictates that the thin shell structure offers a challenge for analysis and computation. Shell response can be generally categorized by states of extension, inextensional bending, edge bending, and edge transverse shear. Simple estimates for the magnitudes of stress, deformation, and resonance in the extensional and inextensional states are provided by ring response. Several shell examples demonstrate the different states and combinations. For excitation frequency above the extensional resonance, such as in impact and acoustic excitation, a fine mesh is needed over the entire shell surface. For this range, modal and implicit methods are of limited value. The example of a sphere impacting a rigid surface shows that plastic unloading occurs continuously. Thus, there are no short cuts; the complete material behavior must be included

    Number of microtubules plotted against Greenwood frequency along the cochlear duct.

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    <p>Inner (a) and outer (b) pillar cells contained more microtubules in the basal, higher frequency regions. There was no obvious relationship with frequency for numbers of microtubules in the Deiters' cell bodies (c) or phalangeal processes (d). Vertical and horizontal lines indicate measurement uncertainty as determined by two standard deviations about the mean from repeated measurement.</p
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