The Europeanization of the political system and the public administration in Germany

No abstractThis article is an analysis of the main patterns of institutional continuity and change that characterize the German federal political system under the influence of ‘Europeanization’. It shows the different degrees of Europeanization to which the German political institutions and public policies have already adapted. Introducing some guiding theoretical approaches that have been applied to raise the analytical validity of Europeanization, it attempts to explain the range and the degree to which the German state and its domestic polities, politics and public policies have been integrated into the EU governance system. After analyzing the core institutional features of the German federal system which generally resist European integration, it presents some evidence on the adjustments made to the (reunified) German intergovernmental system, designed to further stimulate European integration. Finally, it presents a brief summary of the lessons learnt from ‘Europeanizing German federalism’ in order to examine whether typical patterns explaining the Europeanization of the EU member states can be identified

The Europeanization of the political system and the public administration in Germany

No abstractThis article is an analysis of the main patterns of institutional continuity and change that characterize the German federal political system under the influence of ‘Europeanization’. It shows the different degrees of Europeanization to which the German political institutions and public policies have already adapted. Introducing some guiding theoretical approaches that have been applied to raise the analytical validity of Europeanization, it attempts to explain the range and the degree to which the German state and its domestic polities, politics and public policies have been integrated into the EU governance system. After analyzing the core institutional features of the German federal system which generally resist European integration, it presents some evidence on the adjustments made to the (reunified) German intergovernmental system, designed to further stimulate European integration. Finally, it presents a brief summary of the lessons learnt from ‘Europeanizing German federalism’ in order to examine whether typical patterns explaining the Europeanization of the EU member states can be identified

Zur Genese des Kompetenzzentrums

Der Autor beschreibt die Entstehung des Bologna-Zentrums der Hochschulrektorenkonferenz in Deutschland in folgenden Punkten: I. Voraussetzung: Bedarfsanalyse, II. Die Projektidee, und III. Von der Beantragung zur Durchführung des Förderprogramms. (DIPF/ ssch

Does culture matter? The relevance of culture in politics and governance in the Euro-Mediterranean zone

Inhaltsverzeichnis: El Hassan bin Talal: Preface (5-6); Andreas Wimmer: Introduction (7-10); Indra de Soysa, Peter Zervakis: Culture and governance in the Mediterranean - a rational and overview (11-16); Lawrence E. Harrison: The relevance of culture in democratic governance. Lessons from the western hemisphere (17-30); Klaus von Beyme: Culture in politics and governance - European experiences (31-36); Mohammed Arkoun: Penser l'espace Mediterranean (37-68); Erich Weede: Muslim and western civilization - is co-prosperity and peace possible? (69-86); Ergun Oezbudun: Political culture and democracy in Turkey (87-98); Paul Salem: The crisis of political culture in the Arab world - a conflict of paradigms (99-110); Dimitris K. Xenakis, Dimitris Chryssochoou: Euro-Mediterranean formations - cultural imperatives of system change (111-148); Stephan Calleya: Cross-cultural currents in the Mediterranean - what prospects (149-158); Franck Biancheri: Politics and governance in the Mediterranean (159-162); Ludger Kuehnhardt: The Mediterranean - new directions of research and policy-making (163-178)German title: Spielt Kultur eine Rolle? die Bedeutung von Kultur fuer Politik und Regieren im europaeischen MittelmeerraumAvailable from http://www.zei.de/download/zei dp/dp c111 soysa.pdf / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEDEGerman

Recurrent ETNK1 mutations in atypical chronic myeloid leukemia

Despite the recent identification of recurrent SETBP1 mutations in atypical chronic myeloid leukemia (aCML), a complete description of the somatic lesions responsible for the onset of this disorder is still lacking. To find additional somatic abnormalities in aCML, we performed whole-exome sequencing on 15 aCML cases. In 2 cases (13.3%), we identified somatic missense mutations in the ETNK1 gene. Targeted resequencing on 515 hematological clonal disorders revealed the presence of ETNK1 variants in 6 (8.8%) of 68 aCML and 2 (2.6%) of 77 chronic myelomonocytic leukemia samples. These mutations clustered in a small region of the kinase domain, encoding for H243Y and N244S (1/8 H243Y; 7/8 N244S). They were all heterozygous and present in the dominant clone. The intracellular phosphoethanolamine/phosphocholine ratio was, on average, 5.2-fold lower in ETNK1-mutated samples ( P < .05). Similar results were obtained using myeloid TF1 cells transduced with ETNK1 wild type, ETNK1-N244S, and ETNK1-H243Y, where the intracellular phosphoethanolamine/phosphocholine ratio was significantly lower in ETNK1-N244S (0.76 \ub1 0.07) and ETNK1-H243Y (0.37 \ub1 0.02) than in ETNK1-WT (1.37 \ub1 0.32; P = .01 and P = .0008, respectively), suggesting that ETNK1 mutations may inhibit the catalytic activity of the enzyme. In summary, our study shows for the first time the evidence of recurrent somatic ETNK1 mutations in the context of myeloproliferative/myelodysplastic disorders