Bioactive bioflavonoids from Platonia insignis (bacuri) residues as added value compounds

Platonia insignis fruit, popularly known as bacuri, is traditionally used in folk medicine for its anti-inflammatory and antioxidant properties. Therefore, this study determined the chemical composition and biological activities of the bacuri’s shell and seeds extracts, considered residues from its consumption and industrial uses. Four biflavonoids (GB-2a, GB-1a, morelloflavone, and volkensiflavone) were identified in the extracts by high-performance liquid chromatography-diode array detection (HPLC-DAD), liquid chromatography tandem mass spectrometry (LC-MS/MS), and liquid chromatography-solid phase extraction-nuclear magnetic resonance (LC-SPE-NMR) techniques. Morelloflavone was identified as the main compound in the shell ethyl acetate extract, being responsible for the high in vitro antioxidant (50% effective concentration (EC50) ranging from 8.0-10.5 µg mL−1 in different protocols), anti-glycant (80%), and moderate inhibition of nitric oxide (1.56 µg mL−1 for > 90% cell viability) activities. This extract showed promising in vivo anti-inflammatory activity evaluated through the paw edema protocol after its incorporation into a liquid-crystalline drug carrier system, reducing the edema by up to 31%. The results demonstrated the potential of the fruit for the development of drugs of natural origin and corroborated to add economic value to these discarded residues

Lactone derivatives produced by a Phaeoacremonium sp., an endophytic fungus from Senna spectabilis

Three new isoaigialones, A, B, and C (1–3), along with aigialone (4), were isolated from the crude EtOAc extract of a Phaeoacremonium sp., an endophytic fungus obtained from the leaves of Senna spectabilis. The structures of these compounds were elucidated based on the analysis of spectroscopic data. Compounds 2 and 4 were active against the phytopathogenic fungi Cladosporium cladosporioides and C. sphaerospermum. This is the first report of metabolites produced by an Phaeoacremonium sp., associated with S. spectabilis

Biologically Active Eremophilane-Type Sesquiterpenes from Camarops sp., an Endophytic Fungus Isolated from Alibertia macrophylla

Two new eremophilane-type sesquiterpenes, xylarenones F (3) and G (4), have been isolated from solid substrate cultures of a Camarops sp. endophytic fungus isolated from Alibertia macrophylla, together with the known compounds xylarenones C (1) and D (2). The structures and relative configurations of 1-4 were elucidated by extensive NMR and HRESIMS spectroscopic analysis. Due to their effects on the respiratory burst of neutrophils, which included inhibition of the reactive oxygen species production, these sesquiterpenes exhibited potential anti-inflammatory and antioxidant properties.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES

Biologically Active Eremophilane-Type Sesquiterpenes from <i>Camarops</i> sp., an Endophytic Fungus Isolated from <i>Alibertia macrophylla</i>

Two new eremophilane-type sesquiterpenes, xylarenones F (<b>3</b>) and G (<b>4</b>), have been isolated from solid substrate cultures of a <i>Camarops</i> sp. endophytic fungus isolated from <i>Alibertia macrophylla</i>, together with the known compounds xylarenones C (<b>1</b>) and D (<b>2</b>). The structures and relative configurations of <b>1</b>–<b>4</b> were elucidated by extensive NMR and HRESIMS spectroscopic analysis. Due to their effects on the respiratory burst of neutrophils, which included inhibition of the reactive oxygen species production, these sesquiterpenes exhibited potential anti-inflammatory and antioxidant properties

Lactone Derivatives Produced by a <i>Phaeoacremonium</i> sp., an Endophytic Fungus from <i>Senna spectabilis</i>

Three new isoaigialones, A, B, and C (<b>1</b>–<b>3</b>), along with aigialone (<b>4</b>), were isolated from the crude EtOAc extract of a <i>Phaeoacremonium</i> sp., an endophytic fungus obtained from the leaves of <i>Senna spectabilis</i>. The structures of these compounds were elucidated based on the analysis of spectroscopic data. Compounds <b>2</b> and <b>4</b> were active against the phytopathogenic fungi <i>Cladosporium cladosporioides</i> and <i>C. sphaerospermum</i>. This is the first report of metabolites produced by an <i>Phaeoacremonium</i> sp., associated with <i>S. spectabilis.</i