Examination of foramen tympanicum: an anatomical study using cone-beam computed tomography

Background: The foramen tympanicum (FT) is an osseous dehiscence of the temporal bone and usually closes by the age of 5 years. The foramen is located posteromedial to the temporomandibular joint and anteroinferior of the external auditory canal. The aim of this study is to define the prevalence, location and size of the foramen. Materials and methods: We retrospectively examined 200 cone-beam computed tomography (CBCT) images (400 ears). We used a CBCT dental imaging system (GALILEOS, Sirona Dental Systems, Bensheim, Germany) working at 15–30 mA and 98 kV. We noted size and location (unilateral and bilateral) of the present FT. Results: Foramen tympanicum was determined in 11.5% of 200 patients (they had FT at least on one side of the head). This was bilateral in 5 (2.5%) patients. Prevalence of the FT was significintly higher in females (8%) than in males (3.5%). FT was found more frequently on the left side (7.5%) than on the right side (4%). Mean axial diameter was 1.13 mm (range 0.23–4.43 mm), and mean sagittal diameter was 1.44 mm (range 0.22–3.99 mm). Conclusions: Considering that FT was present in 11.75% of patients, radiologists and clinicians should be aware of the possible presence of this defect. It is known that this developmental dehiscence may cause herniation of temporomandibular joint, formation of salivary otorrhea, and spread of tumour or infection to the infratemporal fossa from external auditory canal. This study showed that CBCT may be preferred for imaging these conditions. (Folia Morphol 2018; 77, 2: 335–339

Corrigendum: The Gambian Bone and Muscle Ageing Study: Baseline Data From a Prospective Observational African Sub-Saharan Study.

[This corrects the article on p. 219 in vol. 8, PMID: 28912754.]

Emulsifying properties of plant-derived polypeptide and their conjugates: a self-consistent-field calculation study of the impact of hydrolysis

By considering the hydrolysates of soy protein produced by trypsin as an example, the emulsion stabilizing properties of plant-based protein fragments have been investigated theoretically. We apply Self-Consistent-Field (SCF) calculations to determine the colloidal interactions induced between a pair of droplets stabilized by adsorbed layers of various soy protein fragments. The study is extended to conjugates of such polypeptides, formed by covalent bonding with a suitable hydrophilic sidechain (e.g. a polysaccharide). Our results show that the relatively longer fragments, with a greater number of hydrophobic amino acids, will display a stronger degree of adsorption affinity compared to the smaller hydrolysates, even where the latter may have a higher overall ratio of hydrophobic residues. This suggested that the degree of protein hydrolysis should be carefully controlled and limited to modest values to avoid the generation of a large number of short polypeptides, while still sufficient to improve solubility. While the emulsion stabilizing performance of a protein fragment type is strongly dependent on the conformation it adopts on the interface, we find this to be less critical for the conjugated polypeptides. However, we argue that with increasing degree of hydrolysis, many small fragments will not have the chance to form bonds with polysaccharides. It is demonstrated that the abundance of these unreacted polypeptides in the system severely reduces the efficiency of the conjugated longer protein fragments, preventing their presence on the surface of the droplets through competitive adsorption process

Optical identification and follow-up observations of SRGA J213151.5+491400 -- a new magnetic cataclysmic variable discovered with SRG Observatory

We report results of optical identification and multi-wavelength study of a new polar-type magnetic cataclysmic variable (MCV), SRGA J213151.5+491400, discovered by Spectrum Roentgen-Gamma ($SRG$) observatory in the course of the all-sky survey. We present optical data from telescopes in Turkey (RTT-150 and T100 at the T\"UBITAK National Observatory), and in Russia (6-m and 1-m at SAO RAS), together with the X-ray data obtained with $ART-XC$ and $eROSITA$ telescopes aboard $SRG$ and the $NICER$ observatory. We detect SRGA J213151.5+491400 in a high state in 2020 (17.9 mag) that decreases about 3 mag into a low state (21 mag) in 2021. We find only one significant period using optical photometric time series analysis which reveals the white dwarf spin/orbital period to be 0.059710(1) days (85.982 min). The long slit spectroscopy in the high state yields a power law continuum increasing towards the blue with a prominent He II line along with the Balmer line emissions with no cyclotron humps; consistent with MCV nature. Doppler Tomography confirms the polar nature revealing ballistic stream accretion along with magnetic stream during the high state. These characteristics show that the new source is a polar-type MCV. $SRG$ $ART-XC$ detections yield an X-ray flux of (4.0-7.0)$\times$10$^{-12}$ erg cm$^2$ s$^{-1}$ in the high state. $eROSITA$ detects a dominating hot plasma component (kT$_{\rm{max}}$ $>$ 21 keV in the high state) declining to (4.0-6.0)$\times$10$^{-13}$ erg cm$^2$ s$^{-1}$ in 2021 (low state). The $NICER$ data obtained in the low state reveal a two-pole accretor showing a soft X-ray component at (6-7)$\sigma$ significance with a blackbody temperature of 15-18 eV. A soft X-ray component has never been detected for a polar in the low state before.Comment: 16 pages, 4 Tables and 15 Figures. Accepted for publication in A&A as it stand

Optical Coherence Tomography in the UK Biobank Study – Rapid Automated Analysis of Retinal Thickness for Large Population-Based Studies

Purpose: To describe an approach to the use of optical coherence tomography (OCT) imaging in large, population-based studies, including methods for OCT image acquisition, storage, and the remote, rapid, automated analysis of retinal thickness. Methods: In UK Biobank, OCT images were acquired between 2009 and 2010 using a commercially available “spectral domain” OCT device (3D OCT-1000, Topcon). Images were obtained using a raster scan protocol, 6 mm x 6 mm in area, and consisting of 128 B-scans. OCT image sets were stored on UK Biobank servers in a central repository, adjacent to high performance computers. Rapid, automated analysis of retinal thickness was performed using custom image segmentation software developed by the Topcon Advanced Biomedical Imaging Laboratory (TABIL). This software employs dual-scale gradient information to allow for automated segmentation of nine intraretinal boundaries in a rapid fashion. Results: 67,321 participants (134,642 eyes) in UK Biobank underwent OCT imaging of both eyes as part of the ocular module. 134,611 images were successfully processed with 31 images failing segmentation analysis due to corrupted OCT files or withdrawal of subject consent for UKBB study participation. Average time taken to call up an image from the database and complete segmentation analysis was approximately 120 seconds per data set per login, and analysis of the entire dataset was completed in approximately 28 days. Conclusions: We report an approach to the rapid, automated measurement of retinal thickness from nearly 140,000 OCT image sets from the UK Biobank. In the near future, these measurements will be publically available for utilization by researchers around the world, and thus for correlation with the wealth of other data collected in UK Biobank. The automated analysis approaches we describe may be of utility for future large population-based epidemiological studies, clinical trials, and screening programs that employ OCT imaging