A rapid and non-invasive method for measuring the peak positive pressure of HIFU fields by a laser beam

Based on the acousto-optic interaction, we propose a laser deflection method for rapidly, non-invasively and quantitatively measuring the peak positive pressure of HIFU fields. In the characterization of HIFU fields, the effect of nonlinear propagation is considered. The relation between the laser deflection length and the peak positive pressure is derived. Then the laser deflection method is assessed by comparing it with the hydrophone method. The experimental results show that the peak positive pressure measured by laser deflection method is little higher than that obtained by the hydrophone, confirming that they are in reasonable agreement. Considering that the peak pressure measured by hydrophones is always underestimated, the laser deflection method is assumed to be more accurate than the hydrophone method due to the absence of the errors in hydrophone spatial-averaging measurement and the influence of waveform distortion on hydrophone corrections. Moreover, noting that the Lorentz formula still remains applicable to high-pressure environments, the laser deflection method exhibits a great potential for measuring HIFU field under high-pressure amplitude. Additionally, the laser deflection method provides a rapid way for measuring the peak positive pressure, without the scan time, which is required by the hydrophones

Heat Conduction In A Layered Structure With An Interface Crack Using The Dual Phase Lag Model

In this paper, the transient heat conduction in a layered composite with an insulated interface crack parallel to the boundaries is investigated by using the dual phase lag (DPL) model. Fourier and Laplace transforms are applied and the mixed boundary value problem for the cracked structure under temperature impact is reduced to solving a singular integral equation. The temperature field in time domain is obtained and the intensity factor of temperature gradient is defined. Numerical studies show that overshoot phenomenon may occur due to the combined effect of the insulated crack and application of the DPL heat conduction model. The thermal conductivity and the phase lag parameters have strong influence on the dynamic intensity factor of temperature gradients. The results obtained by the dual phase lag model can be reduced to that by the hyperbolic model and that by the parabolic model

The selective synthesis of single-crystalline CdS nanobelts and nanowires by thermal evaporation at lower temperature

CdS nanobelts and nanowires were successfully synthesized by simple thermal evaporation of CdS powder at a temperature as low as 650 degrees C, using pure H-2 as a carrier gas. The morphology of the products could be conveniently controlled by adjusting the deposition parameters. Electron microscopy studies of the materials showed that the single-crystalline CdS nanowires have a diameter of 200 nm and a length of tens of micrometres, and the nanobelts are 100 - 200 nm in width, 30 nm in thickness and tens of micrometres in length. High-resolution transmission electron microscopy demonstrated that the nanobelts, which are different from the nanowires growing along the [0001] direction, have three types of growth direction: [2 (1) over bar(1) over bar0], [01 (1) over bar0] and [0001]. It is demonstrated that a reductive carrier gas, such as hydrogen, plays an important role in the whole growth process of CdS nanowires and nanobelts

Anti-cancer natural products isolated from chinese medicinal herbs

In recent years, a number of natural products isolated from Chinese herbs have been found to inhibit proliferation, induce apoptosis, suppress angiogenesis, retard metastasis and enhance chemotherapy, exhibiting anti-cancer potential both in vitro and in vivo. This article summarizes recent advances in in vitro and in vivo research on the anti-cancer effects and related mechanisms of some promising natural products. These natural products are also reviewed for their therapeutic potentials, including flavonoids (gambogic acid, curcumin, wogonin and silibinin), alkaloids (berberine), terpenes (artemisinin, β-elemene, oridonin, triptolide, and ursolic acid), quinones (shikonin and emodin) and saponins (ginsenoside Rg3), which are isolated from Chinese medicinal herbs. In particular, the discovery of the new use of artemisinin derivatives as excellent anti-cancer drugs is also reviewed

A rapid and non-invasive method for measuring the peak positive pressure of HIFU fields by a laser beam

Based on the acousto-optic interaction, we propose a laser deflection method for rapidly, non-invasively and quantitatively measuring the peak positive pressure of HIFU fields. In the characterization of HIFU fields, the effect of nonlinear propagation is considered. The relation between the laser deflection length and the peak positive pressure is derived. Then the laser deflection method is assessed by comparing it with the hydrophone method. The experimental results show that the peak positive pressure measured by laser deflection method is little higher than that obtained by the hydrophone, confirming that they are in reasonable agreement. Considering that the peak pressure measured by hydrophones is always underestimated, the laser deflection method is assumed to be more accurate than the hydrophone method due to the absence of the errors in hydrophone spatial-averaging measurement and the influence of waveform distortion on hydrophone corrections. Moreover, noting that the Lorentz formula still remains applicable to high-pressure environments, the laser deflection method exhibits a great potential for measuring HIFU field under high-pressure amplitude. Additionally, the laser deflection method provides a rapid way for measuring the peak positive pressure, without the scan time, which is required by the hydrophones

Micromechanics modelling of ductile fracture

This book summarizes research advances in micromechanics modelling of ductile fractures made in the past two decades. The ultimate goal of this book is to reach manufacturing frontline designers and materials engineers by providing a user-oriented, theoretical background of micromechanics modeling. Accordingly, the book is organized in a unique way and presents a vigorous damage percolation model developed by the authors over the last ten years. This model overcomes almost all difficulties of the existing models and can be used to completely accommodate ductile damage development within a single, measured microstructure frame. Related void damage criteria including nucleation, growth and coalescence are then discussed in detail: how they are improved, when and where they are used in the model, and how the model performs in comparison with the existing models. Sample forming simulations are provided to illustrate the model’s performance

Molecular Dynamics Simulations Correlating Mechanical Property Changes of Alumina with Atomic Voids under Triaxial Tension Loading

The functionalization of nanoporous ceramics for applications in healthcare and defence necessitates the study of the effects of geometric structures on their fundamental mechanical properties. However, there is a lack of research on their stiffness and fracture strength along diverse directions under multi-axial loading conditions, particularly with the existence of typical voids in the models. In this study, accurate atomic models and corresponding properties were meticulously selected and validated for further investigation. Comparisons were made between typical material geometric and elastic properties with measured results to ensure the reliability of the selected models. The mechanical behavior of nanoporous alumina under multiaxial stretching was explored through molecular dynamics simulations. The results indicated that the stiffness of nanoporous alumina ceramics under uniaxial tension was greater, while the fracture strength was lower compared to that under multiaxial loading. The fracture of nanoporous ceramics under multi-axial stretching, was mainly dominated by void and crack extension, atomic bond fracture, and cracking with different orientations. Furthermore, the effects of increasing strain rates on the void volume fraction were found to be similar across different initial radii. It was also found that the increasing tension loading rates had greater effects on decreasing the fracture strain. These findings provide additional insight into the fracture mechanisms of nanoporous ceramics under complex loading states, which can also contribute to the development of higher-scale models in the future