Artist in Residence: Solo Marimba Recital Program

Program listing performers and works performe

An epigenetic switch regulates the ontogeny of AXL-positive/EGFR-TKi-resistant cells by modulating miR-335 expression.

Despite current advancements in research and therapeutics, lung cancer remains the leading cause of cancer-related mortality worldwide. This is mainly due to the resistance that patients develop against chemotherapeutic agents over the course of treatment. In the context of non-small cell lung cancers (NSCLC) harboring EGFR-oncogenic mutations, augmented levels of AXL and GAS6 have been found to drive resistance to EGFR tyrosine kinase inhibitors such as Erlotinib and Osimertinib in certain tumors with mesenchymal-like features. By studying the ontogeny of AXL-positive cells, we have identified a novel non-genetic mechanism of drug resistance based on cell-state transition. We demonstrate that AXL-positive cells are already present as a subpopulation of cancer cells in Erlotinib-naïve tumors and tumor-derived cell lines and that the expression of AXL is regulated through a stochastic mechanism centered on the epigenetic regulation of miR-335. The existence of a cell-intrinsic program through which AXL-positive/Erlotinib-resistant cells emerge infers the need of treating tumors harboring EGFR-oncogenic mutations upfront with combinatorial treatments targeting both AXL-negative and AXL-positive cancer cells

Rethinking Press Freedom and the Politics of Information: Lessons from 19th-Century Mexico

In 1820, a revolution abolished the Mexican Inquisition and inaugurated freedom of the press as the new law of the land. Dr. Zeltsman explores the lively debates triggered by this legal transformation. These debates swirled around the printers who controlled access to Mexico’s printing presses and had suddenly become gatekeepers to an emerging world of free expression. Today, as powerful social media platforms like Facebook and Twitter inspire similar discussions around the world, the case of Mexico helps us think through the relationship among media purveyors, individual rights, politics, and society. No

Sara Zeltsman, DO 2020

Philadelphia DO Class of 2020 portrait.https://digitalcommons.pcom.edu/portraits_2020/1252/thumbnail.jp

Complicated pediatric subglottic granular cell tumor with extensive intraluminal and extraluminal invasion

Subglottic granular cell tumors (GCT) are rare, potentially life threatening benign tumors. Complete resection is necessary, yet care must be taken to preserve laryngeal function. We present the first description of a pediatric subglottic GCT with extensive invasion beyond the confines of the subglottis to include the vocal folds and central neck. Urgent endoscopic debulking avoided tracheotomy and facilitated extubation. Later, complete resection required hemithyroidectomy, laryngofissure and partial cricotracheal resection. We conclude that endoscopic debulking is an appropriate initial treatment. Transmural extension should be suspected in tumors larger than 1 cm and warn of the need for tracheal resection. (C) 2014 Elsevier Ireland Ltd. All rights reserved

During the COVID-19 epidemic, Georgia Southern professors adjust to online teaching

Georgia Southern faculty members, Scott Beck, Corrina Zeltsman, Robert Costomiris, Julie de Chantal, and Robert Dunham provided quotes for this article.https://digitalcommons.georgiasouthern.edu/teach-secondary-facmedia/1017/thumbnail.jp

Impact That Day of the Week has on Length of Stay for Video-assisted Lobectomy.

We aimed to analyze the effect that the day of the week for video-assisted thoracoscopic surgery lobectomy has on length of stay . A retrospective review identified all patients who underwent video-assisted thoracoscopic surgery lobectomy at a single institution from January 2016 to July 2017. In total, 208 patients were divided into 2 groups based on timing of their operation: Operations performed on Monday, Tuesday, or Wednesday were defined as early in the week and those performed on Thursday or Friday were defined as late in the week. We then propensity-matched 81 pairs of patients and analyzed perioperative data and short-term clinical outcomes. A total of 208 patients underwent video-assisted thoracic surgery lobectomy during the study period. Length of stay was significantly decreased by 2.0 days (