Towards Differential Static Magnetic Localization of Commercial Capsule Endoscopes: An Evaluation Using Different Ring and Cylindrical Magnets

Capsule endoscopy is a promising diagnostic tool for the entire gastrointestinal tract. Since a patient swallows the capsules, their size must be sufficiently small. The principal built-in components are cameras, silver-oxide batteries, light emitting diodes, and an antenna for transmitting the video. For diagnosis and treatment, the precise localization of the capsules for specific video frames is required. Recently, static magnetic localization of these capsules with an integrated permanent magnet showed promising results. However, in the state-of-the-art, relatively large magnets compared to the small capsules were used. Therefore, in this extended paper, the localization performance of a recently proposed optimized differential static magnetic localization method for different sized disc and ring magnets was evaluated. The ring magnets were designed for integration with the two batteries of commercial capsules. The magnets were evaluated in static and dynamic scenarios to evaluate the performance of the method in a patient's daily life. It was revealed that the mean position and orientation errors did not exceed 5 mm and 4∘, respectively, for all applied magnets except for the 1.5 and 3 mm long disc magnets. Moreover, the results indicated that the ferromagnetic batteries of capsule endoscopes increase the localization performance when they are centered within a diametrical ring magnet. Overall, it was revealed that the localization performance of the optimized differential method is significantly better than the state-of-the-art even when the magnet volume is significantly reduced compared to previous work. Therefore, it was concluded that 5 mm long disc magnet or a ring magnet are excellent candidates for integration into a commercial capsule for magnetic localization and yield the advantage of being passive magnetic sources.</p

Child-computer interaction, ubiquitous technologies, and big data

In this forum we celebrate research that helps to successfully bring the benefits of computing technologies to children, older adults, people with disabilities, and other populations that are often ignored in the design of mass-marketed products. The children’s technology landscape is changing quickly. The ubiquity of interactive technologies means children can access them just about anytime, anywhere. At the same time, these technologies constantly collect data from and about children, bringing them into the age of big data, voluntarily or not. These developments have the potential to significantly change children’s relationship to technology and the long-term impact of technology use. To discuss these changes, the child-computer-interaction community held a special interest group (SIG) meeting during the CHI 2018 conference

Towards Steering Magnetic Nanoparticles in Drug Targeting Using a Linear Halbach Array

Magnetic nanoparticles offer numerous promising biomedical applications, e.g. magnetic drug targeting. Here, magnetic drug carriers inside the human body are directed towards tumorous tissue by an external magnetic field. However, the success of the treatment strongly depends on the amount of drug carriers, reaching the desired tumor region. This steering process is still an open research topic. In this paper, the previous study of a linear Halbach array is extended by an additional Halbach array with different magnetization angles between two adjacent magnets and investigated numerically using COMSOL Multiphysics. The Halbach arrays are arranged with permanent magnets and generate a relatively large region of a moderately homogeneous, high magnetic field while having a strong gradient. This results in a strong magnetic force, trapping many particles at the magnets. Afterwards, to avoid particle agglomeration, the Halbach array is flipped to its weak side. Therefore, the magnetic flux density, its gradient and the resulting magnetic force are computed for the different Halbach arrays with different constellations of magnetization directions. Since the calculation of the gradient can lead to high errors due to the used mesh in Comsol, the gradient was derived analytically by investigating two different fitting functions. Overall, the array with a 90∘ shifted magnetization performs best, changing the magnetic sides of the array easily and deflecting more particles. Besides, the results revealed that the magnetic force dominates directly underneath the magnets compared to the other existing forces on the SPIONS. Summarized, the results depict that the magnetic force and, thus, the region where the particles are able to get washed out, can be adjusted using low-cost permanent magnets.</p

Evidence for a grounding line fan at the onset of a basal channel under the ice shelf of Support Force Glacier, Antarctica, revealed by reflection seismics

Curvilinear channels on the surface of an ice shelf indicate the presence of large channels at the base. Modelling studies have shown that where these surface expressions intersect the grounding line, they coincide with the likely outflow of subglacial water. An understanding of the initiation and the ice–ocean evolution of the basal channels is required to understand the present behaviour and future dynamics of ice sheets and ice shelves. Here, we present focused active seismic and radar surveys of a basal channel, ∼950 m wide and ∼200 m high, and its upstream continuation beneath Support Force Glacier, which feeds into the Filchner Ice Shelf, West Antarctica. Immediately seaward from the grounding line, below the basal channel, the seismic profiles show an ∼6.75 km long, 3.2 km wide and 200 m thick sedimentary sequence with chaotic to weakly stratified reflections we interpret as a grounding line fan deposited by a subglacial drainage channel directly upstream of the basal channel. Further downstream the seabed has a different character; it consists of harder, stratified consolidated sediments, deposited under different glaciological circumstances, or possibly bedrock. In contrast to the standard perception of a rapid change in ice shelf thickness just downstream of the grounding line, we find a flat topography of the ice shelf base with an almost constant ice thickness gradient along-flow, indicating only little basal melting, but an initial widening of the basal channel, which we ascribe to melting along its flanks. Our findings provide a detailed view of a more complex interaction between the ocean and subglacial hydrology to form basal channels in ice shelves

Faunistic Composition, Ecological Properties and Zoogeographical Composition of the Family Elateridae (Coleoptera) of the Central Anatolian Region of Turkey

The focus of this study was to understand the faunistic composition, ecological properties and zoogeographical composition of Elateridae (Coleoptera) of the Central Anatolian region. 72 species belonging to seven subfamilies and 25 genera were identified. The major part of the Elateridae fauna of the Central Anatolian region is formed by the subfamilies Elaterinae and Cardiophorinae. The genus Cardiophorus was the most species-rich genus. The species composition of the Elateridae fauna of the Central Anatolian region is partially consistent with known Elateridae fauna of Turkey. The Central Anatolian region shares most species with the European part of the Western Palaearctic as does the Elateridae fauna of Turkey. Detailed localities of nine species are given for the first time for Turkey, with emphasis on the Central Anatolian region

Sleep in pituitary insufficient patients compared to patients with depression and healthy controls at baseline and after challenge with CRH

Sleep disturbances are prevalent in both patients with pituitary insufficiency and with depression. The role of corticotropin releasing hormone (CRH), involved in sleep regulation, has not been fully clarified. Pituitary insufficiency is an ideal model for studying sleep-endocrine effects since no consecutive hormone releases and feedback effects occur after hormone administration. 11 male patients with a chronic insufficiency of the anterior pituitary gland (PI) and under stable hormonal substitution were studied during three consecutive nights in the sleep laboratory. The first night served for adapting to laboratory setting, during the second night placebo was administered and during the third night 4 x 50 mu g CRH were injected in pulsatile fashion. Sleep parameters were additionally compared with those of 15 healthy male controls (C) and 15 male patients with depression (D). CRH administration was associated with a numerical increase of wake time (115 +/- 15 to 131 +/- 13 min) and a decrease of REM sleep (89 +/- 8 to 80 +/- 8 min), REM latency (69 +/- 14 to 55 +/- 9 min) and slow wave sleep (66 +/- 16 to 57 +/- 15 min). Yet, none of these changes reached statistical significance. PI showed a worse sleep profile as compared to both control groups, e.g. indicated by a significantly lower sleep efficiency index (PI:0.80 +/- 0.03 vs. C:0.94 +/- 0.01 vs. D:0.87 +/- 0.03). In conclusion sleep-EEG changes after CRH in PI patients resemble those found in in part in patients with depression. Sleep in anterior pituitary insufficiency was impaired despite full hormonal substitution possibly suggesting an alteration of the receptor organisation of brain structures involved in sleep regulation