Enhancing the Administrator-School Counselor Relationship

This paper explores several published articles reporting on the relationship between administration and school counselors in the United States. The paper provides evidence of past and current administration perceptions of the school counseling position and explains how these perceptions have affected the school counseling profession, position, and roles within the school system. The paper also suggests steps that school counselors should take to promote an environment of understanding and respect for their new vision role within the school, specifically the use of the model and standards set by the American School Counselor Association (ASCA). In addition, this paper emphasizes the importance of the relationship between administration and school counselors while also examining research-based suggestions and guidelines for the two parties to follow that develop and enhance this relationship

IM toolbox for the present and future to support data synthesis activities, An

The SGS-LTER research site was established in 1980 by researchers at Colorado State University as part of a network of long-term research sites within the US LTER Network, supported by the National Science Foundation. Scientists within the Natural Resource Ecology Lab, Department of Forest and Rangeland Stewardship, Department of Soil and Crop Sciences, and Biology Department at CSU, California State Fullerton, USDA Agricultural Research Service, University of Northern Colorado, and the University of Wyoming, among others, have contributed to our understanding of the structure and functions of the shortgrass steppe and other diverse ecosystems across the network while maintaining a common mission and sharing expertise, data and infrastructure.This poster displays four examples of topics and tools currently being implemented and developed by information management staff at the Shortgrass Steppe LTER, across the LTER Network and within USDA Agricultural Research Service (ARS). These tools are necessary in order to synthesize similar data sets from different researchers, agencies, and institutions. These tools were designed provide to support to Principal Investigators, educators, students, and policy makers that need to synthesize information to make better decisions about planning their research, coursework and land management strategies. The four areas to be presented are Geographical Information Systems (GIS) and Remote Sensing, standardization of metadata using Ecological Metadata Language (EML), integration of relational database management systems for different agencies, and the creation of useful dynamic web pages. GIS and Remote Sensing are powerful tools that allow researchers to analyze, model, and predict ecological factors and outcomes that shape the shortgrass steppe by integrating spatial and non-spatial data collected at the field site. EML consists of a number of modules that define an extensible mark-up language (XML) that creates a standard syntax for ecological metadata. This concept allows for sharing of standard metadata and data across not only the LTER Network, but throughout the broader ecological community. SGS is researching new database technologies to managing the growing amount of standard non-spatial data from the ARS and LTER as well as GIS and Remote Sensed data. This also will address the need for multi-user data access and database integration with the SGS website. An SGS Website was launched 8 years ago to provide general site information as well as detailed research information. The web site will be enhanced over the next year to improve query tools, submit metadata online, improve integration with various ecological research databases, and implement the EML standards

Through the looking glass: what do we see, what have we learned, what can we share? Information management at the Shortgrass Steppe Long Term Ecological Research site

The SGS-LTER research site was established in 1980 by researchers at Colorado State University as part of a network of long-term research sites within the US LTER Network, supported by the National Science Foundation. Scientists within the Natural Resource Ecology Lab, Department of Forest and Rangeland Stewardship, Department of Soil and Crop Sciences, and Biology Department at CSU, California State Fullerton, USDA Agricultural Research Service, University of Northern Colorado, and the University of Wyoming, among others, have contributed to our understanding of the structure and functions of the shortgrass steppe and other diverse ecosystems across the network while maintaining a common mission and sharing expertise, data and infrastructure.This poster displays the development of a successful information management system at a Long Term Ecological Research (LTER) site that has a rich history of data collection and management. Over sixty years of data from three separate projects are incorporated into the Shortgrass Steppe (SGS) LTER information management system and databases. People with different strengths and expertise ranging from clerical administrator, programmer, to ecologist, have filled the role of Information Manager (IM) at the SGS-LTER. Today the information management needs of the SGS are provided by a team of IMs with various levels of expertise in a wide variety of domains from information technology administration to education and outreach. It is critical for IMs at any long-term research site to understand how information and data were managed in the past and what recent changes have been added to the system, in order to effectively implement a management plan for the future. We are able to evaluate the effectiveness of different approaches to information management and have a commitment to share our successes with the information management community

Monitoring physical and psychosocial symptom trajectories in ovarian cancer patients receiving chemotherapy

<p>Abstract</p> <p>Background</p> <p>Diagnosis and treatment of ovarian cancer (OC) entail severe symptom burden and a significant loss of quality of life (QOL). Somatic and psychological impairments may persist well beyond active therapy. Although essential for optimal symptom management as well as for the interpretation of treatment outcomes, knowledge on the course of QOL-related issues is scarce. This study aimed at assessing the course of depressive symptoms, anxiety, fatigue and QOL in patients with OC over the course of chemotherapy until early after-care.</p> <p>Methods</p> <p>23 patients were assessed longitudinally (eight time points) with regard to symptom burden (depression, anxiety, fatigue, and QOL) by means of patient-reported outcome instruments (HADS, MFI-20, EORTC QLQ-C30/-OV28) and clinician ratings (HAMA/D) at each chemotherapy cycle and at the first two aftercare visits.</p> <p>Results</p> <p>Statistically significant decrease over time was found for depressive symptoms and anxiety as well as for all fatigue scales. With regard to QOL, results indicated significant increase for 11 of 15 QOL scales, best for Social (effect size = 1.95; <it>p </it>< 0.001), Emotional (e.s. = 1.62; <it>p </it>< 0.001) and Physical Functioning (e.s. = 1.47; <it>p </it>< 0.001). Abdominal Symptoms (e.s. = 1.01; <it>p </it>= 0.009) decreased, Attitudes towards Disease and Treatment (e.s. = 1.80; <it>p </it>< 0.001) improved significantly over time. Analysis of Sexual Functioning was not possible due to a high percentage of missing responses (61.9%).</p> <p>Conclusions</p> <p>The present study underlines the importance of longitudinal assessment of QOL in order to facilitate the identification of symptom burden in OC patients. We found that patients show high levels of fatigue, anxiety and depressive symptoms and severely impaired QOL post-surgery (i.e. at start of chemotherapy) but condition improves considerably throughout chemotherapy reaching nearly general population symptoms levels until aftercare.</p

Dubious effects of methadone as an "anticancer" drug on ovarian cancer cell-lines and patient-derived tumor-spheroids

Background. The opioid agonist D, L-methadone exerts analgesic effects via the mu opioid receptor, encoded by OPRM1 and therefore plays a role in chronic pain management. In preclinical tumor-models D,L-methadone shows apoptotic and chemo-sensitizing effects and was therefore hyped as an off-label "anticancer" drug without substantiation from clinical trials. Its effects in ovarian cancer (OC) are completely unexplored. Methods. We analyzed OPRM1-mRNA expression in six cisplatin-sensitive, two cisplatin-resistant OC cell-lines, 170 OC tissue samples and 12 non-neoplastic control tissues. Pro-angiogenetic, cytotoxic and apoptotic effects of D,L-methadone were evaluated in OC cell-lines and four patient-derived tumor-spheroid models. Results. OPRM1 was transcriptionally expressed in 69% of OC-tissues and in three of eight OC cell-lines. D, L-methadone exposure significantly reduced cell-viability in five OC cell-lines irrespective of OPRM1 expression. D, L-methadone, applied alone or combined with cisplatin, showed no significant effects on apoptosis or VEGF secretion in cell-lines. Notably, in two of the four sphero id models, treatment with D, L-methadone significantly enhanced cell growth (by up to 121%), especially after long-term exposure. This is consistent with the observed attenuation of the inhibitory effects of cisplatin in three spheroid models when adding D, L-methadone. The effect of methadone treatment on VEGF secretion in tumor-spheroids was inconclusive. Conclusions. Our study demonstrates that certain OC samples express OPRM1, which, however, is not a prerequisite for D, L-methadone function. As such, D,L-methadone may exert also detrimental effects by stimulating the growth of certain OC-cells and abrogating cisplatin's therapeutic effect. (C) 2022 The Authors. Published by Elsevier Inc.Peer reviewe

A conditionally replicating adenovirus with strict selectivity in killing cells expressing epidermal growth factor receptor

AbstractVirotherapy of cancer using oncolytic adenoviruses has shown promise in both preclinical and clinical settings. One important challenge to reach the full therapeutic potential of oncolytic adenoviruses is accomplishing efficient infection of cancer cells and avoiding uptake by normal tissue through tropism modification. Towards this goal, we constructed and characterized an oncolytic adenovirus, carrying mutated capsid proteins to abolish the promiscuous adenovirus native tropism and encoding a bispecific adapter molecule to target the virus to the epidermal growth factor receptor (EGFR). The new virus displayed a highly selective targeting profile, with reduced infection of EGFR-negative cells and efficient killing of EGFR-positive cancer cells including primary EGFR-positive osteosarcoma cells that are refractory to infection by conventional adenoviruses. Our method to modify adenovirus tropism might thus be useful to design new oncolytic adenoviruses for more effective treatment of cancer