Political party development in post-war societies: the institutionalization of parties and party systems in El Salvador and Cambodia

This thesis argues that civil war has a significant, lasting impact on the formation, development and institutionalization of parties and party systems. Through in-depth examination of the cases of El Salvador and Cambodia it shows that dominant party systems and uneven institutionalization of individual political parties prevalent in post-war societies can to a not insignificant extent be attributed to war-related factors such as war-time origins of parties, the way in which war ended, the nature of the peace agreement, and post-war design of electoral, media and other public institutions. Its focus on party and party system institutionalization is rooted in the Western-oriented party politics literature, which suggests that the nature of electoral competition, the impact of societal cleavages and the workings of formal political institutions are primary explanatory factors. By contrast, this thesis argues that in non-Western developing countries affected by civil war, war-related factors and post-war security, socio-economic and political conditions are equally if not more important for understanding post-war party development. Through a structured focused comparison of party and party system institutionalization in El Salvador and Cambodia based on extensive interviews and field research, the thesis demonstrates that the war-time origins of the main Salvadoran and Cambodian parties have left a deep imprint on their organizational structures and leadership style, just as war-time political exclusion set the tone for unbalanced party competition after the war. Although El Salvador’s party system is more institutionalized than Cambodia’s and there are many other differences, there are also clear cross-national patterns of unequal individual party institutionalization and ruling party dominance that are a product of the war. Given that institutionalized parties and a competitive party system are important ingredients for a healthy democracy these findings are important for understanding the challenges and prospects of democratization in these and other post-war countries

Individual atrasentan exposure is associated with long-term kidney and heart failure outcomes in patients with type 2 diabetes and chronic kidney disease

Atrasentan, an endothelin receptor antagonist, showed clinically significant albuminuria reduction with minimal signs of fluid retention in phase 2 trials. We evaluated whether plasma exposure was associated with long-term outcomes for kidney protection and heart failure in the phase 3 SONAR trial (n=3668) in type 2 diabetics with chronic kidney disease. A population pharmacokinetic model was used to estimate plasma exposure of atrasentan 0.75 mg/day. Parametric time-to-event models were used to quantify the association between plasma exposure and long-term outcomes. Mean atrasentan plasma exposure was 41.4 ng.h/mL (2.5th to 97.5th P: 14.2 to 139.9). Compared to placebo, a mean atrasentan exposure translated in a hazard ratio of 0.76 (95% CI: 0.28-0.85) for kidney events and 1.13 (95% CI: 1.03-2.20) for heart failure events. At the mean atrasentan exposure the kidney protective effect was larger than the increase in heart failure supporting the atrasentan 0.75 mg/day dose in this population

Whole brain 7T-fMRI during pelvic floor muscle contraction in male subjects

Aim: The primary aim of this study is to demonstrate that 7-tesla functional magnetic resonance imaging (7T-fMRI) can visualize the neural representations of the male pelvic floor in the whole brain of a single subject. Methods: In total, 17 healthy male volunteers (age 20-47) were scanned in a 7T-MRI scanner (Philips Achieva). The scanning protocol consisted of two functional runs using a multiband echo planar imaging sequence and a T1-weighted scan. The subjects executed two motor tasks, one involving consecutive pelvic floor muscle contractions (PFMC) and a control task with tongue movements. Results: In single subjects, results of both tasks were visualized in the cortex, putamen, thalamus, and the cerebellum. Activation was seen during PFMC in the superomedial and inferolateral primary motor cortex (M1), supplementary motor area (SMA), insula, midcingulate gyrus (MCG), putamen, thalamus, and in the anterior and posterior lobes of the cerebellum. During tongue movement, activation was seen in the inferolateral M1, SMA, MCG, putamen, thalamus, and anterior and posterior lobes of the cerebellum. Tongue activation was found in the proximity of, but not overlapping with, the PFMC activation. Connectivity analysis demonstrated differences in neural networks involved in PFMC and tongue movement. Conclusion: This study demonstrated that 7T-fMRI can be used to visualize brain areas involved in pelvic floor control in the whole brain of single subjects and defined the specific brain areas involved in PFMC. Distinct differences between brain mechanisms controlling the pelvic floor and tongue movements were demonstrated using connectivity analysis

SLAIN2 links microtubule plus end–tracking proteins and controls microtubule growth in interphase

SLAIN2’s interactions with multiple different microtubule plus end–tracking proteins stimulate processive microtubule polymerization and ensure proper microtubule organization

Increase in BNP in response to endothelin-receptor antagonist atrasentan is associated with incident heart failure

Objectives: The purpose of this study was to assess if early changes in B-type natriuretic peptide (BNP) and body weight during atrasentan treatment predict heart failure (HF) risk. Background: The endothelin receptor antagonist atrasentan reduced the risk of kidney failure in patients with type 2 diabetes mellitus and chronic kidney disease (CKD) in the SONAR (Study of Diabetic Nephropathy with Atrasentan) trial, although with a numerically higher incidence of HF hospitalization. Methods: Participants with type 2 diabetes and CKD entered an open-label enrichment phase to assess response to atrasentan 0.75 mg/day. Participants without substantial fluid retention (>3 kg body weight increase or BNP increase to >300 pg/mL), were randomized to atrasentan 0.75 mg/day or placebo. Cox proportional hazards regression was used to assess the effects of atrasentan vs placebo on the prespecified safety outcome of HF hospitalizations. Results: Among 3,668 patients, 73 (4.0%) participants in the atrasentan and 51 (2.8%) in the placebo group developed HF (HR: 1.39; 95% CI: 0.97-1.99; P = 0.072). In a multivariable analysis, HF risk was associated with higher baseline BNP (HR: 2.32; 95% CI: 1.81-2.97) and percent increase in BNP during response enrichment (HR: 1.46; 95% CI: 1.08-1.98). Body weight change was not associated with HF. Exclusion of patients with at least 25% BNP increase during enrichment attenuated the risk of HF with atrasentan (HR: 1.02; 95% CI: 0.66-1.56) while retaining nephroprotective effects (HR: 0.58; 95% CI: 0.44-0.78). Conclusions: In patients with type 2 diabetes and CKD, baseline BNP and early changes in BNP in response to atrasentan were associated with HF hospitalization, highlighting the importance of natriuretic peptide monitoring upon initiation of atrasentan treatment. (Study Of Diabetic Nephropathy With Atrasentan [SONAR]; NCT01858532)

The Long-Lived Disks in the Eta Chamaeleontis Cluster

We present IRS spectra and revised MIPS photometry for the 18 members of the Eta Chamaeleontis cluster. Aged 8 Myr, the Eta Cha cluster is one of the few nearby regions within the 5-10 Myr age range, during which the disk fraction decreases dramatically and giant planet formation must come to an end. For the 15 low-mass members, we measure a disk fraction ~50%, high for their 8 Myr age, and 4 of the 8 disks lack near-IR excesses, consistent with the empirical definition of "transition'' disks. Most of the disks are comparable to geometrically flat disks. The comparison with regions of different ages suggests that at least some of the "transition" disks may represent the normal type of disk around low-mass stars. Therefore, their flattened structure and inner holes may be related to other factors (initial masses of the disk and the star, environment, binarity), rather than to pure time evolution. We analyze the silicate dust in the disk atmosphere, finding moderate crystalline fractions (~10-30%) and typical grain sizes ~1-3 micron, without any characteristic trend in the composition. These results are common to other regions of different ages, suggesting that the initial grain processing occurs very early in the disk lifetime (<1 Myr). Large grain sizes in the disk atmosphere cannot be used as a proxy for age, but are likely related to higher disk turbulence. The dust mineralogy varies between the 8-12micron and the 20-30 micron features, suggesting high temperature dust processing and little radial mixing. Finally, the analysis of IR and optical data on the B9 star Eta Cha reveals that it is probably surrounded by a young debris disk with a large inner hole, instead of being a classical Be star.Comment: 35 pages, 6 tables, 8 figures; Accepted by Ap

Correction:How the COVID-19 pandemic highlights the necessity of animal research (vol 30, pg R1014, 2020)

(Current Biology 30, R1014–R1018; September 21, 2020) As a result of an author oversight in the originally published version of this article, a number of errors were introduced in the author list and affiliations. First, the middle initials were omitted from the names of several authors. Second, the surname of Dr. van Dam was mistakenly written as “Dam.” Third, the first name of author Bernhard Englitz was misspelled as “Bernard” and the surname of author B.J.A. Pollux was misspelled as “Pullox.” Finally, Dr. Keijer's first name was abbreviated rather than written in full. These errors, as well as various errors in the author affiliations, have now been corrected online

Domestic elites and external actors in post-conflict democratisation: mapping interactions and their impact

Following the end of the Cold War, post-conflict democratisation has rarely occurred without a significant international involvement. This contribution argues that an explanation of the outcomes of post-conflict democratisation requires more than an examination of external actors, their mission mandates or their capabilities and deficiencies. In addition, there is a need to study domestic elites, their preferences and motivations, as well as their perceptions of and their reactions to external interference. Moreover, the patterns of external–internal interactions may explain the trajectory of state-building and democracy promotion efforts. These issues deserve more attention from both scholars and practitioners in the fields of peace- and state-building, democracy promotion, regime transition and elite research. Analyses of external actors and domestic elites in post-conflict democratisation should therefore address three principal issues: (1) the identification of relevant domestic elites in externally induced or monitored state-building and democratisation processes, (2) the dynamics of external–domestic interactions and (3) the impact of these interactions on the outcomes of post-conflict democratisation

Canon deel 12: Milieueconomie

De milieueconomie behelst de economische analyse van milieu en natuurlijke hulpbronnen, en het volledig inpassen van milieu en natuurlijke hulpbronnen in een economische analyse. Het vak heeft zich sinds het einde van de jaren zestig ontwikkeld tot een volwaardige tak van de economische wetenschap. Dit wordt geillustreerd door een groot aantal studieboeken, handboeken en internationale tijdschriften