European Union Instruments and Strategies for Sustainable Urban Mobility: Exploiting PUMS and ITS to Develop an Efficient Car Sharing Proposal

Abstract In the last decade, a big European effort has been made in terms of research, strategies and initiatives to boost new forms of sustainable urban mobility to replace individual transport. Among the other instruments identified to achieve this goal the European Commission emphasises integrated planning at all mobility levels, to be realised through the writing of the PUMS, and its management and through Intelligent Transport Systems (ITS). Under these two conditions, car sharing is expected to become an efficient sustainable transport service, able to limit the use of private cars and to facilitate multi-modality for public transport

PUMS E ITS: LE STRATEGIE DEL PROGRAMMA UE HORIZON2020 PER UNA MOBILITA' "SMART"

Nowadays, the need to develop and boost new forms of sustainable urban mobility to replace urban transport is a key iusse, addressed by European Commission with a big effort in terms of research, strategies and initiatives. In this context, two relevant instruments identified to reach this goal are integrated planning at all the mobility levels and its management. The former may be realized through the processing of PUMS (Urban Plan of Sustainable Mobility), while the latter through Intelligent Transport Systems (ITS). Among the other sustainable transport services, car sharing is expected to become efficient and is expected to limit the use of private cars, thus facilitating multi-modal for public transports. The present text deals with a presentation of the state-of.art practices in terms of car sharing, particularly referring to the case of Turin. DOI: http://dx.medra.org/10.19254/LaborEst.12.10           

STATISTICHE CULTURALI – IL CENSIMENTO DEL PATRIMONIO CULTURALE NELL’AREA TIRRENICA DELLA PROVINCIA DI REGGIO CALABRIA

The finding study is a dissemination tool of tangible and intangible heritage of a part of Reggio Calabria’s province. The area under examination, which includes the towns of the Tyrrhenian area of the province, except for the chief town, covers an area of 1111.76 Km2, for a total of 43 municipalities; for each of them the study has identified the relevant elements or attractors (environmental, physical and socio-economic resources). The combined analysis of economic, social, cultural and environmental studies, mapped on the territory, has allowed to understand the critical points where the gap is wider between the coastal areas, leaders in tourism, and the inner ones. The promotion of cultural heritage contributes to society well-being, not only as an action of protection, but also as a sustainable answer to the job application and as a regeneration and revitalization strategy of social contexts such as inner areas.  DOI: http://dx.medra.org/10.19254/LaborEst.13.0

L’ANALISI SOCIO-ECONOMICA A SUPPORTO DEI PROCESSI DECISIONALI: IL CASO DELL’AREA TIRRENICA DELLA CITTA’ METROPOLITANA DI REGGIO CALABRIA

The paper is part of an applied research study on the Tirreno Reggino for the implementation of a development model based on endogenous resources of the area. In the first step, the principal cultural (tangible and intangible) attractors have been analysed, giving back a framework of those resources considered as key elements to structure the demand for Cultural tourism and a potential new brand: the Cultural Landscape of the Tirreno Reggino. This paper represents the second step of a study, analysing the demographic trends, employment, local production systems and tourism, describing the socio-economic structure, and possible development paths of the case study area. The paper contributes to the implementation of an effective context analysis, as a scientific basis for a systemic local development proposal ina a highly fragile environment.DOI: http://dx.medra.org/10.19254/LaborEst.14.0

Hepatocellular carcinoma recurrence after direct-acting antiviral therapy: an individual patient data meta-analysis

Objective: The benefit of direct-acting antivirals (DAAs) against HCV following successful treatment of hepatocellular carcinoma (HCC) remains controversial. This meta-analysis of individual patient data assessed HCC recurrence risk following DAA administration. Design: We pooled the data of 977 consecutive patients from 21 studies of HCV-related cirrhosis and HCC, who achieved complete radiological response after surgical/locoregional treatments and received DAAs (DAA group). Recurrence or death risk was expressed as HCC recurrence or death per 100 person-years (100PY). Propensity score-matched patients from the ITA.LI.CA. cohort (n=328) served as DAA-unexposed controls (no-DAA group). Risk factors for HCC recurrence were identified using random-effects Poisson. Results: Recurrence rate and death risk per 100PY in DAA-treated patients were 20 (95% CI 13.9 to 29.8, I2=74.6%) and 5.7 (2.5 to 15.3, I2=54.3), respectively. Predictive factors for recurrence were alpha-fetoprotein logarithm (relative risk (RR)=1.11, 95% CI 1.03 to 1.19; p=0.01, per 1 log of ng/mL), HCC recurrence history pre-DAA initiation (RR=1.11, 95% CI 1.07 to 1.16; p<0.001), performance status (2 vs 0, RR=4.35, 95% CI 1.54 to 11.11; 2 vs 1, RR=3.7, 95% CI 1.3 to 11.11; p=0.01) and tumour burden pre-HCC treatment (multifocal vs solitary nodule, RR=1.75, 95% CI 1.25 to 2.43; p<0.001). No significant difference was observed in RR between the DAA-exposed and DAA-unexposed groups in propensity score-matched patients (RR=0.64, 95% CI 0.37 to 1.1; p=0.1). Conclusion: Effects of DAA exposure on HCC recurrence risk remain inconclusive. Active clinical and radiological follow-up of patients with HCC after HCV eradication with DAA is justified

Papillary lesions of the breast: A molecular progression?

Introduction. Breast papillary lesions represent a heterogeneous group of tumors ranging from benign to malignant, including several intermediate forms. Malignant papillary tumors are rare and their molecular characterization is still limited. A few studies pointed to the presence of specific genetic alterations that could be relevant both for diagnostic purposes and to elucidate tumour development and progression. In order to look into the issue, we compared LOH relative frequencies of four microsatellite markers located on chromosome 16 in a set of morphologically different papillary breast lesions. LOH at TP53 locus was also analyzed throughout lesions. Materials and methods. Fifteen cases were analyzed. Sections including a malignant papillary lesion, a benign lesion (when available), and normal breast tissue were selected. Fifteen malignant and twelve benign areas were microdissected using the Leica laser microdissection system (AS LMD). After DNA extraction samples were tested for the following markers: TP53, D16S423, D16S310, DS163210 and D16S476, and analyzed on ABI PRISM 3100 (Applied Biosystems, Foster city CA). Results. Fourteen malignant lesions and twelve paired benign areas appeared to be informative for at least one of the four markers on chromosome 16. In particular, LOH at loci 16p13 and 16q21 was detected in both benign and malignant lesions, whereas LOH at locus 16q23 was limited to malignant lesions. Nine malignant and seven benign lesions were informative for LOH at TP53 locus, that was found to be significantly associated (p=0.01) with the malignant phenotype. Conclusions. Our data suggest an involvement of chromosome 16 mutations in the early steps of breast papillary tumorigenesis. TP53 deletion and possibly LOH at 16q23 appear to play a role as progression factors, being they significantly associated with malignant transformation of breast papilloma. © Springer 2005

Application of Principal Component Analysis to Elucidate Experimental and Theoretical Information

Principal Component Analysis has been widely used in different scientific areas and fordifferent purposes. The versatility and potentialities of this unsupervised method for dataanalysis, allowed the scientific community to explore its applications in different fields. Evenwhen the principles of PCA are the same in what algorithms and fundamentals concerns, thestrategies employed to elucidate information from a specific data set (experimental and/ortheoretical), mainly depend on the expertise and needs of each researcher.In this chapter, we will describe how PCA has been used in three different theoretical andexperimental applications, to explain the relevant information of the data sets. Theseapplications provide a broad overview about the versatility of PCA in data analysis andinterpretation. Our main goal is to give an outline about the capabilities and strengths ofPCA to elucidate specific information. The examples reported include the analysis ofmatured distilled beverages, the determination of heavy metals attached to bacterialsurfaces and interpretation of quantum chemical calculations. They were chosen asrepresentative examples of the application of three different approaches for data analysis:the influence of data pre-treatments in the scores and loadings values, the use of specificoptical, chemical and/or physical properties to qualitatively discriminate samples, and theuse of spatial orientations to group conformers correlating structures and relative energies.This reason fully justifies their selection as case studies. This chapter also pretends to be areference for those researchers that, not being in the field, may use these methodologies totake the maximum advantage from their experimental results.Fil: Araujo Andrade, Cuauhtémoc. Universidad Autónoma de Zacatecas; MéxicoFil: Frausto Reyes, Claudio. Universidad Autónoma de Zacatecas; MéxicoFil: Gerbino, Oscar Esteban. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Investigación y Desarrollo en Criotecnología de Alimentos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigación y Desarrollo en Criotecnología de Alimentos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Investigación y Desarrollo en Criotecnología de Alimentos; ArgentinaFil: Mobili, Pablo. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Investigación y Desarrollo en Criotecnología de Alimentos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigación y Desarrollo en Criotecnología de Alimentos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Investigación y Desarrollo en Criotecnología de Alimentos; ArgentinaFil: Tymczyszyn, Emma Elizabeth. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Investigación y Desarrollo en Criotecnología de Alimentos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigación y Desarrollo en Criotecnología de Alimentos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Investigación y Desarrollo en Criotecnología de Alimentos; ArgentinaFil: Esparza Ibarra, Edgar L.. Universidad Autónoma de Zacatecas; MéxicoFil: Ivanov Tsonchev, Rumen. Universidad Autónoma de Zacatecas; MéxicoFil: Gomez Zavaglia, Andrea. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Investigación y Desarrollo en Criotecnología de Alimentos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigación y Desarrollo en Criotecnología de Alimentos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Investigación y Desarrollo en Criotecnología de Alimentos; Argentin