135 research outputs found
The automated computation of tree-level and next-to-leading order differential cross sections, and their matching to parton shower simulations
We discuss the theoretical bases that underpin the automation of the
computations of tree-level and next-to-leading order cross sections, of their
matching to parton shower simulations, and of the merging of matched samples
that differ by light-parton multiplicities. We present a computer program,
MadGraph5_aMC@NLO, capable of handling all these computations -- parton-level
fixed order, shower-matched, merged -- in a unified framework whose defining
features are flexibility, high level of parallelisation, and human intervention
limited to input physics quantities. We demonstrate the potential of the
program by presenting selected phenomenological applications relevant to the
LHC and to a 1-TeV collider. While next-to-leading order results are
restricted to QCD corrections to SM processes in the first public version, we
show that from the user viewpoint no changes have to be expected in the case of
corrections due to any given renormalisable Lagrangian, and that the
implementation of these are well under way.Comment: 158 pages, 27 figures; a few references have been adde
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O-GlcNAc modification blocks the aggregation and toxicity of the protein α-synuclein associated with Parkinson's disease.
Several aggregation-prone proteins associated with neurodegenerative diseases can be modified by O-linked N-acetyl-glucosamine (O-GlcNAc) in vivo. One of these proteins, α-synuclein, is a toxic aggregating protein associated with synucleinopathies, including Parkinson's disease. However, the effect of O-GlcNAcylation on α-synuclein is not clear. Here, we use synthetic protein chemistry to generate both unmodified α-synuclein and α-synuclein bearing a site-specific O-GlcNAc modification at the physiologically relevant threonine residue 72. We show that this single modification has a notable and substoichiometric inhibitory effect on α-synuclein aggregation, while not affecting the membrane binding or bending properties of α-synuclein. O-GlcNAcylation is also shown to affect the phosphorylation of α-synuclein in vitro and block the toxicity of α-synuclein that was exogenously added to cells in culture. These results suggest that increasing O-GlcNAcylation may slow the progression of synucleinopathies and further support a general function for O-GlcNAc in preventing protein aggregation
Model-independent extraction of matrix elements from top-quark measurements at hadron colliders
Current methods to extract the quark-mixing matrix element from
single-top production measurements assume that : top quarks decay into quarks with 100% branching fraction,
s-channel single-top production is always accompanied by a quark and
initial-state contributions from and quarks in the -channel
production of single top quarks are neglected. Triggered by a recent
measurement of the ratio
performed by the D0 collaboration, we consider a extraction method
that takes into account non zero d- and s-quark contributions both in
production and decay. We propose a strategy that allows to extract consistently
and in a model-independent way the quark mixing matrix elements ,
, and from the measurement of and from single-top
measured event yields. As an illustration, we apply our method to the Tevatron
data using a CDF analysis of the measured single-top event yield with two jets
in the final state one of which is identified as a -quark jet. We constrain
the matrix elements within a four-generation scenario by combining
the results with those obtained from direct measurements in flavor physics and
determine the preferred range for the top-quark decay width within different
scenarios.Comment: 36 pages, 17 figure
Les Houches 2015: Physics at TeV Colliders Standard Model Working Group Report
This Report summarizes the proceedings of the 2015 Les Houches workshop on
Physics at TeV Colliders. Session 1 dealt with (I) new developments relevant
for high precision Standard Model calculations, (II) the new PDF4LHC parton
distributions, (III) issues in the theoretical description of the production of
Standard Model Higgs bosons and how to relate experimental measurements, (IV) a
host of phenomenological studies essential for comparing LHC data from Run I
with theoretical predictions and projections for future measurements in Run II,
and (V) new developments in Monte Carlo event generators.Comment: Proceedings of the Standard Model Working Group of the 2015 Les
Houches Workshop, Physics at TeV Colliders, Les Houches 1-19 June 2015. 227
page
Radial versus femoral access in patients with acute coronary syndromes undergoing invasive management: a randomised multicentre trial.
Summary Background It is unclear whether radial compared with femoral access improves outcomes in unselected patients with acute coronary syndromes undergoing invasive management. Methods We did a randomised, multicentre, superiority trial comparing transradial against transfemoral access in patients with acute coronary syndrome with or without ST-segment elevation myocardial infarction who were about to undergo coronary angiography and percutaneous coronary intervention. Patients were randomly allocated (1:1) to radial or femoral access with a web-based system. The randomisation sequence was computer generated, blocked, and stratified by use of ticagrelor or prasugrel, type of acute coronary syndrome (ST-segment elevation myocardial infarction, troponin positive or negative, non-ST-segment elevation acute coronary syndrome), and anticipated use of immediate percutaneous coronary intervention. Outcome assessors were masked to treatment allocation. The 30-day coprimary outcomes were major adverse cardiovascular events, defined as death, myocardial infarction, or stroke, and net adverse clinical events, defined as major adverse cardiovascular events or Bleeding Academic Research Consortium (BARC) major bleeding unrelated to coronary artery bypass graft surgery. The analysis was by intention to treat. The two-sided α was prespecified at 0·025. The trial is registered at ClinicalTrials.gov, number NCT01433627. Findings We randomly assigned 8404 patients with acute coronary syndrome, with or without ST-segment elevation, to radial (4197) or femoral (4207) access for coronary angiography and percutaneous coronary intervention. 369 (8·8%) patients with radial access had major adverse cardiovascular events, compared with 429 (10·3%) patients with femoral access (rate ratio [RR] 0·85, 95% CI 0·74-0·99; p=0·0307), non-significant at α of 0·025. 410 (9·8%) patients with radial access had net adverse clinical events compared with 486 (11·7%) patients with femoral access (0·83, 95% CI 0·73-0·96; p=0·0092). The difference was driven by BARC major bleeding unrelated to coronary artery bypass graft surgery (1·6% vs 2·3%, RR 0·67, 95% CI 0·49-0·92; p=0·013) and all-cause mortality (1·6% vs 2·2%, RR 0·72, 95% CI 0·53-0·99; p=0·045). Interpretation In patients with acute coronary syndrome undergoing invasive management, radial as compared with femoral access reduces net adverse clinical events, through a reduction in major bleeding and all-cause mortality. Funding The Medicines Company and Terumo. © 2015 Elsevier Ltd
Chemoproteomics reveals Toll-like receptor fatty acylation
Partial funding for Open Access provided by The Ohio State University Open Access Fund.Background: Palmitoylation is a 16-carbon lipid post-translational modification that increases protein hydrophobicity.
This form of protein fatty acylation is emerging as a critical regulatory modification for multiple aspects of cellular
interactions and signaling. Despite recent advances in the development of chemical tools for the rapid identification
and visualization of palmitoylated proteins, the palmitoyl proteome has not been fully defined. Here we sought to
identify and compare the palmitoylated proteins in murine fibroblasts and dendritic cells.
Results: A total of 563 putative palmitoylation substrates were identified, more than 200 of which have not been
previously suggested to be palmitoylated in past proteomic studies. Here we validate the palmitoylation of several new
proteins including Toll-like receptors (TLRs) 2, 5 and 10, CD80, CD86, and NEDD4. Palmitoylation of TLR2, which was
uniquely identified in dendritic cells, was mapped to a transmembrane domain-proximal cysteine. Inhibition of TLR2
S-palmitoylation pharmacologically or by cysteine mutagenesis led to decreased cell surface expression and a decreased
inflammatory response to microbial ligands.
Conclusions: This work identifies many fatty acylated proteins involved in fundamental cellular processes as well as cell
type-specific functions, highlighting the value of examining the palmitoyl proteomes of multiple cell types. Spalmitoylation
of TLR2 is a previously unknown immunoregulatory mechanism that represents an entirely novel avenue
for modulation of TLR2 inflammatory activity.This work was supported by funding from the NIH/NIAID (grant R00AI095348 to J.S.Y.), the NIH/NIGMS (R01GM087544 to HCH), and the Ohio State University Public Health Preparedness for Infectious Diseases (PHPID) program. NMC is supported by the Ohio State University Systems and Integrative Biology Training Program (NIH/NIGMS grant T32GM068412). BWZ is a fellow of the National Science Foundation Graduate Research Fellowship Program (DGE-0937362)
Top-quark mass effects in double and triple Higgs production in gluon-gluon fusion at NLO
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