1,051 research outputs found
Complementary and alternative medicine (CAM) in pediatric rheumatology: an European perspective
To analyse the use of complementary and alternative medicine (CAM) in children with rheumatic diseases, treated at a paediatric rheumatology centre in Italy
A new FSA approach for in situ -ray spectroscopy
An increasing demand of environmental radioactivity monitoring comes both
from the scientific community and from the society. This requires accurate,
reliable and fast response preferably from portable radiation detectors. Thanks
to recent improvements in the technology, -spectroscopy with sodium
iodide scintillators has been proved to be an excellent tool for in-situ
measurements for the identification and quantitative determination of
-ray emitting radioisotopes, reducing time and costs. Both for
geological and civil purposes not only K, U, and Th have
to be measured, but there is also a growing interest to determine the
abundances of anthropic elements, like Cs and I, which are used
to monitor the effect of nuclear accidents or other human activities.
The Full Spectrum Analysis (FSA) approach has been chosen to analyze the
-spectra. The Non Negative Least Square (NNLS) and the energy
calibration adjustment have been implemented in this method for the first time
in order to correct the intrinsic problem related with the
minimization which could lead to artifacts and non physical results in the
analysis.
A new calibration procedure has been developed for the FSA method by using in
situ -spectra instead of calibration pad spectra. Finally, the new
method has been validated by acquiring -spectra with a 10.16 cm x 10.16
cm sodium iodide detector in 80 different sites in the Ombrone basin, in
Tuscany. The results from the FSA method have been compared with the laboratory
measurements by using HPGe detectors on soil samples collected in the different
sites, showing a satisfactory agreement between them. In particular, the
Cs isotopes has been implemented in the analysis since it has been
found not negligible during the in-situ measurements.Comment: accepted by Science of Total Environment: 8 pages, 10 figures, 3
table
Genetic similarities among Modenese, Romagnola and three Veneto chicken breeds
A recent Italian poultry study (Zanon et al., 2001) showed, in the last decades, the presence of 90 poultry breeds (53 of them are chicken's), they represent a historical and cultural patrimony, and a genetic source of biodiversity
A Very Low Resource Language Speech Corpus for Computational Language Documentation Experiments
Most speech and language technologies are trained with massive amounts of
speech and text information. However, most of the world languages do not have
such resources or stable orthography. Systems constructed under these almost
zero resource conditions are not only promising for speech technology but also
for computational language documentation. The goal of computational language
documentation is to help field linguists to (semi-)automatically analyze and
annotate audio recordings of endangered and unwritten languages. Example tasks
are automatic phoneme discovery or lexicon discovery from the speech signal.
This paper presents a speech corpus collected during a realistic language
documentation process. It is made up of 5k speech utterances in Mboshi (Bantu
C25) aligned to French text translations. Speech transcriptions are also made
available: they correspond to a non-standard graphemic form close to the
language phonology. We present how the data was collected, cleaned and
processed and we illustrate its use through a zero-resource task: spoken term
discovery. The dataset is made available to the community for reproducible
computational language documentation experiments and their evaluation.Comment: accepted to LREC 201
Spinal motoneuron synaptic plasticity after axotomy in the absence of inducible nitric oxide synthase
<p>Abstract</p> <p>Background</p> <p>Astrocytes play a major role in preserving and restoring structural and physiological integrity following injury to the nervous system. After peripheral axotomy, reactive gliosis propagates within adjacent spinal segments, influenced by the local synthesis of nitric oxide (NO). The present work investigated the importance of inducible nitric oxide synthase (iNOS) activity in acute and late glial responses after injury and in major histocompatibility complex class I (MHC I) expression and synaptic plasticity of inputs to lesioned alpha motoneurons.</p> <p>Methods</p> <p><it>In vivo </it>analyses were carried out using C57BL/6J-iNOS knockout (iNOS<sup>-/-</sup>) and C57BL/6J mice. Glial response after axotomy, glial MHC I expression, and the effects of axotomy on synaptic contacts were measured using immunohistochemistry and transmission electron microscopy. For this purpose, 2-month-old animals were sacrificed and fixed one or two weeks after unilateral sciatic nerve transection, and spinal cord sections were incubated with antibodies against classical MHC I, GFAP (glial fibrillary acidic protein - an astroglial marker), Iba-1 (an ionized calcium binding adaptor protein and a microglial marker) or synaptophysin (a presynaptic terminal marker). Western blotting analysis of MHC I and nNOS expression one week after lesion were also performed. The data were analyzed using a two-tailed Student's <it>t </it>test for parametric data or a two-tailed Mann-Whitney <it>U </it>test for nonparametric data.</p> <p>Results</p> <p>A statistical difference was shown with respect to astrogliosis between strains at the different time points studied. Also, MHC I expression by iNOS<sup>-/- </sup>microglial cells did not increase at one or two weeks after unilateral axotomy. There was a difference in synaptophysin expression reflecting synaptic elimination, in which iNOS<sup>-/- </sup>mice displayed a decreased number of the inputs to alpha motoneurons, in comparison to that of C57BL/6J.</p> <p>Conclusion</p> <p>The findings herein indicate that iNOS isoform activity influences MHC I expression by microglial cells one and two weeks after axotomy. This finding was associated with differences in astrogliosis, number of presynaptic terminals and synaptic covering of alpha motoneurons after lesioning in the mutant mice.</p
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