Selamento Marginal em Lesões Cervicais Não Cariosas Escleróticas

TCC (graduação) - Universidade Federal de Santa Catarina. Centro de Ciências da Saúde. Odontologia.Lesões não cariosas, originadas por erosão, abrasão ou abfração, provocam na polpa uma reação adversa que resulta na hipermineralização da dentina, deixando-a esclerótica. Este trabalho revisou publicações científicas que abordassem o tratamento restaurador de lesões cervicais não cariosas com presença de dentina esclerótica, como o intuito de sugerir quais sistemas adesivos teriam melhor desempenho no selamento marginal dessas restaurações. Realizou-se uma busca nas bases de dados PubMed, Lilacs e Scienc Direct, combinando os descritores sclerotic dentin e adhesive. Os artigos encontrados apontaram lesões cervicais como o melhor substrato para testar a eficiência dos sistemas adesivos. Mostraram grande aceitação por parte dos autores e eficiência clínica dos adesivos autocondicionantes no selamento marginal de lesões escleróticas, pois há baixa taxa de falhas e coloração marginal dessas restaurações. No entanto, muitos autores ressaltam a necessidade de se desenvolverem mais pesquisas na área, principalmente para investigar o sucesso clínico a longo prazo.Non-carious cervical lesions are caused by erosion, abrasion or abfraction, and they stimulate an adverse reaction in the pulp resulting in hypermineralized dentin, leaving it sclerotic. This paper reviewed scientific publications that approached the restorative treatment of non-carious cervical lesions in the presence of sclerotic dentin, in order to suggest which adhesive system would perform better in marginal sealing of these restorations. We conducted a research in the databases PubMed, Lilacs and Scienc Direct, with the keywords sclerotic dentin and adhesive. The articles found pointed cervical lesions as the best substrate to test the efficiency of adhesive systems. They showed great acceptance by authors and clinical efficiency of the self-etching adhesives on the microleakage of sclerotic lesions, and there are low failure rate and marginal staining in these restorations. However, many authors emphasize the need to develop further research in this area, mainly about long-term results

Millennials invisíveis: onde está essa geração no mercado de trabalho?

TCC (graduação) - Universidade Federal de Santa Catarina. Centro de Comunicação e Expressão. Jornalismo.Este Trabalho de Conclusão de Curso é um vídeo documentário que retrata a realidade da geração de jovens nascidos entre 1989 e 2001 relacionado ao mercado de trabalho e relações com a tecnologia e informação. Através de uma ótica socioeconômica, analisamos as diferentes realidades de jovens que têm hoje entre 18 e 30 anos de idade, questionando quais espaços ocupam no mercado de trabalho e quais oportunidades que têm de acordo com as condições econômicas e sociais

Medium-sized to large mammals of Serra do Tombador, Cerrado of Brazil

The Cerrado is the second largest biome of Brazil and one of the most threatened, mainly due to habitat conversion and agricultural expansion. At the same time, the fauna of the Cerrado is poorly known. In this study, undertaken from April to July of 2012, we provide a checklist of the medium-sized to large mammals recorded by camera traps in the Reserva Particular do Patrimônio Natural Serra do Tombador, a private protected area located in northern Goiás state. With a total effort of 2,340 camera-days, we recorded 17 species including rare and threatened species, among them jaguar (Panthera onca), giant armadillo (Priodontes maximus), tapir (Tapirus terrestris) and giant anteater (Myrmecophaga tridactyla). Our results suggest that the surveyed protected area has importance in the conservation of mammals in the Cerrado

Clinical phenotypic variability in an Italian family bearing the IVS6+ 5_8delGTGA mutation in PGRN gene

Background Frontotemporal dementia (FTD) is a complex presenile disorder characterized by behavioural changes and executive functions, expression of fronto-temporal degeneration. Hereditary FTD accounts for 20-30% of cases and, in the past decade, mutations in the microtubule associated protein tau (MAPT)gene were identified as a main genetic causes of familial FTD. In 2006, mutations in the gene encoding progranulin (PGRN) were reported, to account for a wide part of the familial FTD cases. Clinically, an high phenotypic variability within and among the kindreds is reported in the familial FTD associated with PGRN mutations and occasionally the memory deficits are the first symptoms, resembling Alzheimer's disease (AD). We report an Italian family with dementia associated with a PGRN mutation characterized by a deletion of 4 base pairs inside the intron 6 of the gene, leading to haploin sufficiency In our kindred, all three affected patients carried the mutation, but presented very different clinical phenotypes, evoking FTD, AD and rapidly-progressive dementia mimicking prion disease. Methods Informations on the members of the first, second and third generations were obtained conducting interviews with relatives, while for the three patients studied, the clinical evidence of dementia symptoms and their characterization was documented directly with sequential neurological examinations, cognitive assessments and neuroimaging. Blood sample collection and DNA extraction from peripheral blood lymphocytes for genetic analysis were performed after written informed consent of the patients. Results In our pedigree, the PGRN mutated patients are affected by dementia with three different clinical pictures: FTD, AD and rapidly progressive dementia mimicking prion disease. Neuropsychological examinations supported these diagnoses, documenting generalized deficits of cortical functions in AD patient and deficits in executive functions and in language in FTD patient. Regarding neuroimaging, in the same two cases MRI results do not correspond to the clinical diagnosis. Conclusions These findings confirms the marked heterogeneity of the clinico-radiological features in patients with PGNR mutations and underline the need of considering mutations of this gene as causes of familial dementing diseases with atypical or uncommon features or discrepancies between the clinical and the neuroimaging findings

Rat subcutaneous tissue response to calcium silicate containing different arsenic concentrations

Objective: To evaluate the response of rat subcutaneous tissue in implanted polyethylene tubes that were filled with GMTA Angelus and Portland cements containing different arsenic concentrations. Material and Methods: Atomic absorption spectrophotometry was utilized to obtain the values of the arsenic concentration in the materials. Thirty-six rats were divided into 3 groups of 12 animals for each experimental period. Each animal received two implants of polyethylene tubes filled with different test cements and the lateral of the tubes was used as a control group. After 15, 30 and 60 days of implantation, the animals were killed and the specimens were prepared for descriptive and morphometric analysis considering: inflammatory cells, collagen fibers, fibroblasts, blood vessels and other components. The results were analyzed utilizing the Kuskal-Wallis test and the Dunn's Multiple test for comparison (

Analysis of the reaction of subcutaneous tissues in rats and the antimicrobial activity of calcium hydroxide paste used in association with different substances

The aim of this study was to evaluate the subcutaneous tissue response in rats and the antimicrobial activity of intracanal calcium hydroxide dressings mixed with different substances against E. faecalis. Fifty four rats were divided into three experimental groups according to the vehicle in the calcium hydroxide treatment: 0.4% chlorohexidine in propylene glycol (PG),Casearia sylvestris Sw in PG and calcium hydroxide+PG (control group). The pastes were placed into polyethylene tubes and implanted into the subcutaneous tissue. After 7, 14 and 30 days, the samples were processed and histologically evaluated (hematoxylin and eosin). The tissue surface in contact with the material was analyzed, and the quantitative analysis determined the volume density occupied by the inflammatory infiltrate (giant cells, polymorphonuclear cells and mononuclear cells), fibroblasts, collagen fibers and blood vessels. For the antimicrobial analysis, 20 dentin blocks infected with E. faecalis were treated with calcium hydroxide pastes in different vehicles; 0.4% chlorhexidine in PG, PG, extract fromCasearia sylvestris Sw in PG and a positive control (infection and without medication) for 7 days. The efficiency of the pastes was evaluated by the live/dead technique and confocal microscopy. The results showed that 0.4% chlorhexidine induced a higher inflammatory response than the other groups. The Casearia sylvestris Sw extract showed satisfactory results in relation to the intensity of the inflammatory response. In the microbiological test, there were no statistical differences between the evaluated intracanal dressings and the percentage of bacterial viability was between 33 and 42%. The control group showed an 86% viability. Antimicrobial components such as chlorhexidine or Casearia sylvestris Sw did not improve the antimicrobial activity against E. faecalis in comparison to the calcium hydroxide+PG treatment. In addition, the incorporation of chlorhexidine in the calcium hydroxide paste promoted the highest inflammatory response

Ocotea nutans (Nees) Mez (Lauraceae): chemical composition, antioxidant capacity and biological properties of essential oil

The present study was undertaken to assess the potential uses of the essential oil obtained from Ocotea nutans (Nees) Mez. The hydrodistilled essential oil from O. nutans leaves was analyzed by gas chromatography-mass spectrometry. Fifty-eight compounds representing 87,29% of the total leaf essential oil components were identified, of which biciclogermacrene(11.41%), germacrene-D (4.89%), bisabolol11-ol(3.73%) and spathulenol (3.71%) were the major compounds. The essential oil from O. nutans were tested for antibacterial activity using the minimum inhibitory concentracion (MIC) method, Artemia salina method, larvicidal activity in Aedes aegypti, and antioxidant capacity.The antioxidant activity measured by the phosphomolybdenum complex and Prussian blue method had positive results. The minimum inhibitory concentration for the microorganisms tested allowed moderate inhibitionfor Enterococcus faecalis(MIC=500 µg/mL). Artemia salina were toxic to the organisms in the study (LC50= 71,70 μg /mL). The essential oil showed remarkable larvicidal activity potencial (LC50= 250 µg/mL). The present results showed that O. nutans essential oil has potential biological uses

Laccases in food processing: Current status, bottlenecks and perspectives

Background: Laccases (benzenediol:oxygen oxidoreductases, EC 1.10.3.2) catalyze the oxidation of a wide variety of organic and inorganic substrates, typically p-diphenols with a concomitant reduction of oxygen (O2) to water. Several molecules naturally occurring in foods and beverages (e.g., phenols, carbohydrates, unsatured fatty acids and thiol-containing proteins) can be modified by laccases. Hence, the interaction between laccase and these molecules can and has been widely explored by the food industry for various technological purposes. Scope and approach: The present work aims at providing a critical review on the current uses of laccases in food processing, at discussing the main bottlenecks for its popularization, and at presenting future perspectives. Both scientific reports and patents, covering preferably the last five years, were considered. Key findings and conclusions: Several traditional uses of laccases in food processing including baking, beverage, and dairy industries were detailed. Special efforts were developed, however, in analyzing future perspectives. The latter includes the application of laccases in the synthesis of new compounds with functional properties, such as antioxidant and antimicrobial activities. No less attention was devoted to the recent developments in the field of crosslinking of polymers, such as proteins and polysaccharides. Scaling up of the production of the laccase itself and especially of the novel products derived from its applications in the food sector will be essential for cost reduction and, consequently, for market expansion.This work was supported by the National Council of Scientific and Technological Development (CNPq, Proc. 404898/2016-5). R.C.G. Corrêa is a research grant recipient of Cesumar Institute of Science Technology and Innovation (ICETI). C.G. Kato (Proc. 151189/2019-6), E. Backes (Proc. 304406/2019-8), R.M. Peralta, R.A. Peralta, R.F. Peralta Muniz Moreira and A. Bracht are research grant recipients from CNPq.info:eu-repo/semantics/publishedVersio