Picolinate cross-bridged cyclam, chelate with metallic cations and use thereof

PCT/EP2014074415 - 2014-11-12The present invention relates to chelates resulting from the complexation of picolinate cross-bridged cyclams of formula (I), wherein the substituents L1-L4 and R1-R4 are defined as in the claims, with metallic cations. The invention further relates to picolinate cross-bridged cyclam ligands of formula (I). Another object of the invention is the use of chelates of the invention in nuclear medicine and the use of ligands of the invention in cations detection or epuration of effluents

Picolinate cross-bridged cyclam, chelate with metallic cations and use thereof

PCT/EP2014074415 - 2014-11-12The present invention relates to chelates resulting from the complexation of picolinate cross-bridged cyclams of formula (I), wherein the substituents L1-L4 and R1-R4 are defined as in the claims, with metallic cations. The invention further relates to picolinate cross-bridged cyclam ligands of formula (I). Another object of the invention is the use of chelates of the invention in nuclear medicine and the use of ligands of the invention in cations detection or epuration of effluents

Porphyrines de bismuth (aspects fondamentaux et appliqués)

Le bismuth possède deux radio-isotopes (212bi et 213bi) qui présentent des propriétés radio-physiques très prometteuses pour une application en radioimmunothérapie (RIT). Ainsi, plusieurs familles de ligands ont été étudiées afin de complexer les radio-isotopes du bismuth et permettre le couplage du complexe forme avec l anticorps qui apporte la spécificité de cible dans l organisme. Parmi ces ligands figurent les porphyrines. Cependant, les complexes porphyriniques du bismuth sont peu stables et possèdent des cinétiques de formation très lentes compte tenu de la période des radio-isotopes de cet élément. Afin d améliorer la performance des porphyrines en vue d une application en RIT, nous avons synthétisé diverses séries de porphyrines fonctionnalisées. Ces fonctionnalisations ont permis d obtenir des complexes plus stables avec une cinétique de complexation plus rapide tout en offrant la possibilité d introduire des fonctions de couplage avec l anticorps.RENNES1-BU Sciences Philo (352382102) / SudocSudocFranceF

Coordination of bismuth and lead in porphyrins: Towards an in-situ generator for α-radiotherapy?

International audienc

Recent advances in metalloporphyrin-based catalyst design towards carbon dioxide reduction: from bio-inspired second coordination sphere modifications to hierarchical architectures

International audienceResearch in the development of new molecular catalysts for the selective transformation of CO2 to reduced forms of carbon is attracting enormous interest from chemists. Molecular catalyst design hinges on the elaboration of ligand scaffolds to manipulate the electronic and structural properties for the fine tuning of the reactivity pattern. A cornucopia of ligand sets have been designed along this line and more and more are being reported. In this quest, the porphyrin molecular platform has been under intensive focus due to the unmatched catalytic properties of metalloporphyrins. There have been rapid advances in this particular field during the last few years wherein both electronic and structural aspects in the second coordination spheres have been addressed to shift the overpotential and improve the catalytic rates and product selectivity. Metalloporphyrins have also attracted much attention in terms of the elaboration of hybrid materials for heterogeneous catalysis. Here too, some promising activities have made metalloporphyrin derivatives serious candidates for technological implementation. This review collects the recent advances centred around the chemistry of metalloporphyrins for the reduction of CO2

Bismuth insertion in functionalized porphyrins: influence of the structure delivering substituted malonic acid groups

International audienc

Pre-shaped Aromatic Picket Porphyrins Bearing Neutral Oxygen Donors and Their Bismuth Complexes: Synthesis and Coordination Studies

International audienc

Shaping the Electrocatalytic Performance of Metal Complexes for CO2 Reduction

International audienceThe mass scale catalytic transformation of carbon dioxide (CO2) into reduced forms of carbon is an imperative to address the ever-increasing anthropogenic emission. Understanding the mechanistic routes leading to the multi-electron-proton conversion of CO2 provides handles for chemists to overcome the kinetically and thermodynamically hard challenges and further optimize these processes. Through extensive electrochemical investigations, Prof. J-M. Savéant and coworkers have made accessible to chemists invaluable electro-analytical tools to address and position the electrocatalytic performance of molecular catalysts grounded on a theoretical basis. Furthermore, he has bequeathed lessons to future generations on ways to improve the catalytic activity and on the electrocatalytic zone we must target. As a tribute to his accomplishments, we recall here a few aspects on the tuning of iron porphyrin catalysts by playing on electronic effects, proton delivery, hydrogen bonding and electrostatic interactions and its implications to other catalytic systems