The Great Wave: Margaret Thatcher, The Neo-liberal Age, and the Transformation of Modern Britain

Margaret Thatcher was Prime Minister of Great Britain from 1979-1990. During this period she implemented policies that profoundly changed British society, politics, and its economy through neoliberal policies. This work seeks to analyze those policies and its impact on Great Britain. From Thatcher’s economic policies of neoliberalism, social policies toward the unemployed, and her foreign policy of national reinvigoration, this work seeks to provide a panoramic analysis of Thatcher’s premiership and its long term impact on Britain.This work will also seek to argue that Thatcher and her policies were both revolutionary in their thinking and contributed to realigning British political thought. It is because of this these profound changes that these policies were so controversial as it shaped the modern political debate within Great Britain as this work seeks to demonstrate. This work will also argue further that Thatcher’s policies and their impact are still being felt today in Britain and and will likely continue to do so due to the sheer transformative nature of those policies this work will analyze

Sinister Intentions and Devastating Results: Intervention and Duration of Civil Conflict

In the post-Second World War era, intra-state conflict has become an increasingly prominent feature of the international system. Accompanying the increase in civil conflicts has been interventions by third-parties seeking to influence the outcome of those civil conflicts. This has had a decisive impact on the duration of civil conflict that this work seeks to analyze in detail. Using duration of civil conflict as the dependent variable and intervention as the independent variable, this work will seek to demonstrate empirically that intervention in civil conflict has a significant impact on prolonging the duration of the conflict and can contribute to complicating efforts to reach peace settlements ending civil conflict. This work seeks to achieve this by analyzing the motives of states for intervening and how it contextualizes intervention and its impact on duration and types of third-party interventions that impact duration. It will do this through analyzing relevant scholarship regarding these topics and how they impact intervention and duration of civil conflict

The Great Misread: Life and Death in Islam and Its Relation to the West

Details of death in the Islamic faith and how it is related to the two major monotheistic religions of the West, Judaism and Christianity

Modeling of controlled flexible structures with impulsive loads

The characteristic wave approach is developed as an alternative to modal methods which may lead to significant errors in the presence of impulsive or concentrated loads. The method is applied to periodic structures. Some special phenomena like cumulation effects and transitions to ergodicity are analyzed

Chaos motion in robot manipulators

It is shown that a simple two-link planar manipulator exhibits a phenomenon of global instability in a subspace of its configuration space. A numerical example, as well as results of a graphic simulation, is given

Complexity of the XY antiferromagnet at fixed magnetization

We prove that approximating the ground energy of the antiferromagnetic XY model on a simple graph at fixed magnetization (given as part of the instance specification) is QMA-complete. To show this, we strengthen a previous result by establishing QMA-completeness for approximating the ground energy of the Bose-Hubbard model on simple graphs. Using a connection between the XY and Bose-Hubbard models that we exploited in previous work, this establishes QMA-completeness of the XY model

Periodic and discrete Zak bases

Weyl's displacement operators for position and momentum commute if the product of the elementary displacements equals Planck's constant. Then, their common eigenstates constitute the Zak basis, each state specified by two phase parameters. Upon enforcing a periodic dependence on the phases, one gets a one-to-one mapping of the Hilbert space on the line onto the Hilbert space on the torus. The Fourier coefficients of the periodic Zak bases make up the discrete Zak bases. The two bases are mutually unbiased. We study these bases in detail, including a brief discussion of their relation to Aharonov's modular operators, and mention how they can be used to associate with the single degree of freedom of the line a pair of genuine qubits.Comment: 15 pages, 3 figures; displayed abstract is shortened, see the paper for the complete abstrac

Mechanism for Multiple Ligand Recognition by the Human Transferrin Receptor

Transferrin receptor 1 (TfR) plays a critical role in cellular iron import for most higher organisms. Cell surface TfR binds to circulating iron-loaded transferrin (Fe-Tf) and transports it to acidic endosomes, where low pH promotes iron to dissociate from transferrin (Tf) in a TfR-assisted process. The iron-free form of Tf (apo-Tf) remains bound to TfR and is recycled to the cell surface, where the complex dissociates upon exposure to the slightly basic pH of the blood. Fe-Tf competes for binding to TfR with HFE, the protein mutated in the iron-overload disease hereditary hemochromatosis. We used a quantitative surface plasmon resonance assay to determine the binding affinities of an extensive set of site-directed TfR mutants to HFE and Fe-Tf at pH 7.4 and to apo-Tf at pH 6.3. These results confirm the previous finding that Fe-Tf and HFE compete for the receptor by binding to an overlapping site on the TfR helical domain. Spatially distant mutations in the TfR protease-like domain affect binding of Fe-Tf, but not iron-loaded Tf C-lobe, apo-Tf, or HFE, and mutations at the edge of the TfR helical domain affect binding of apo-Tf, but not Fe-Tf or HFE. The binding data presented here reveal the binding footprints on TfR for Fe-Tf and apo-Tf. These data support a model in which the Tf C-lobe contacts the TfR helical domain and the Tf N-lobe contacts the base of the TfR protease-like domain. The differential effects of some TfR mutations on binding to Fe-Tf and apo-Tf suggest differences in the contact points between TfR and the two forms of Tf that could be caused by pH-dependent conformational changes in Tf, TfR, or both. From these data, we propose a structure-based model for the mechanism of TfR-assisted iron release from Fe-Tf

Collaborative Opportunistic Navigation

Aerospace Engineering and Engineering Mechanic