Model Based System Engineering for the development of System on Chip

Abstract. Model Based System Engineering (MBSE) has been utilized in auto manufacturing industries, airplane manufacturing and maintenance, and factory process automation industries. These are some of the complex fields. As SoC design is a complex process and requires years of work, MBSE can reduce time, complexity, reuse, and maintenance costs. It seems a fruitful idea/decision to take MBSE into use in SoC design depending on the previously mentioned elements. System on Chip (SoC) is obtaining the interest of many big companies. Therefore, MBSE will represent a huge competitive advantage once it is taken fully into the systems engineering roles of SoC. The existence of geographically dispersed teams, complexity of systems, interdisciplinarity, personalized system description, and their integration can be enabled by MBSE. As an emerging paradigm for the systems of the 21st century, MBSE paved the way for creating successful systems (for the companies) that are end to end connected. This research focuses on making use of MBSE in SoC. The thesis will show how SoC processes can be implemented in one complete model with top to bottom approach. Firstly, the traditional systems engineering approach has been explained with its tools and examples. Secondly, the need for taking up MBSE by the systems engineers is expressed. This contains the applications, use in modern systems, and benefits of MBSE. Moreover, MBSE methodology tools, languages, and their use in SoC is illustrated with examples. As SoC development is a huge and complex process; therefore, a small component of the chip has been taken in consideration for the purpose of understanding and making of the thesis. MBSE is a model-based approach hence a language needs to be present to produce these models and that language is SysML and OPD/OPL. SysML language and MagicDraw tool is used for expressing the architecture of the system. MagicDraw supports several external evaluators for evaluation of expressions and MATLAB is one of them. With MagicDraw we can do simulations, input parameters, and analyze data by processing on it using algorithms developed in MATLAB

Nitric oxide production by Biomphalaria glabrata haemocytes: effects of Schistosoma mansoni ESPs and regulation through the extracellular signal-regulated kinase pathway

BACKGROUND: Schistosoma mansoni uses Biomphalaria glabrata as an intermediate host during its complex life cycle. In the snail, the parasite initially transforms from a miracidium into a mother sporocyst and during this process excretory-secretory products (ESPs) are released. Nitric oxide (NO) and its reactive intermediates play an important role in host defence responses against pathogens. This study therefore aimed to determine the effects of S. mansoni ESPs on NO production in defence cells (haemocytes) from schistosome-susceptible and schistosome-resistant B. glabrata strains. As S. mansoni ESPs have previously been shown to inhibit extracellular signal-regulated kinase (ERK) phosphorylation (activation) in haemocytes from susceptible, but not resistant, B. glabrata the regulation of NO output by ERK in these cells was also investigated. RESULTS: Haemocytes from resistant snails challenged with S. mansoni ESPs (20 mug/ml) over 5 h displayed an increase in NO production that was 3.3 times greater than that observed for unchallenged haemocytes; lower concentrations of ESPs (0.1-10 mug/ml) did not significantly increase NO output. In contrast, haemocytes from susceptible snails showed no significant change in NO output following challenge with ESPs at any concentration used (0.1-20 mug/ml). Western blotting revealed that U0126 (1 muM or 10 muM) blocked the phosphorylation (activation) status of ERK in haemocytes from both snail strains. Inhibition of ERK signalling by U0126 attenuated considerably intracellular NO production in haemocytes from both susceptible and resistant B. glabrata strains, identifying ERK as a key regulator of NO output in these cells. CONCLUSION: S. mansoni ESPs differentially influence intracellular NO levels in susceptible and resistant B. glabrata haemocytes, possibly through modulation of the ERK signalling pathway. Such effects might facilitate survival of S. mansoni in its intermediate host

Response of sunflower hybrids to management practices under irrigated arid-environment

Two field experiments were established at Research Farm, Bahauddin Zakariya University, (BZU) Multan, Pakistan, during the spring season of 2009 to study the interactive effect of sunflower (Helianthus annuus L.) hybrids in terms of growth, fraction of intercepted radiation (Fi), intercepted photo-synthetically active radiation (PAR), yield components and oil contents to planting geometries and nitrogen rates. Experiment 1 comprised nine treatments having combinations of three hybrids (H1 = 19012; H2 = Hysun-33; H3 = DK-4040) and three planting geometries (PG1 = flat sowing; PG2 = ridge sowing; PG3 = bed sowing) while, experiment 2 comprised 16 treatments having combinations of four hybrids (H1 = 00989; H2 = 01087; H3 = 00997; H4 = 010226) and four nitrogen rates (N0 = control; N1 = 75; N2 = 150 and N3 = 225 kg ha-1). The results revealed that, the ontogeny maximum plant height ranged from 32 to 216 cm and from 36 to 299 cm in experiments 1 and 2, respectively. The ontogeny maximum number of leaves plant-1 were 21, 32, 28, 21 and 14 in experiment 1 and 20, 33, 29, 20 and 9 in experiment 2, respectively on respective harvest dates. The ontogeny maximum head diameter was 17, 22 and 25 cm and 20, 21 and 29 cm on respective dates for experiments 1 and 2, respectively. The ontogeny Fi values for experiments 1 and 2, ranged from 0.11 to 0.99 and from 0.09 to 0.99, respectively. The cumulative intercepted PAR ranged from 492 to 812 MJ m-2 and from 627 to 897 MJ m-2 in experiments 1 and 2, respectively. The achene weight ranged from 69.7 to 127.5g and from 65.4 to 93.4g in experiments 1 and 2, respectively. The number of achenes head-1 ranged from 919 to 1868 and 925 to 1678 for experiments 1 and 2, respectively. The achene oil contents ranged from 38.1 to 43.1% and 34.5 to 47.6% for experiments 1 and 2, respectively. However, average oil contents value was 41% for both experiments. From the results, the use of higher nitrogen rates and ridge or bed sowing techniques are recommended for the management practices for the newly developed sunflower hybrids farmers.Keywords: Sunflower hybrids, planting geometries, nitrogen rates, intercepted PA

Implementation of Parallel Synchronization Method of Generators for Power & Cost Saving in University of Gujrat

In the current economic and political scenario of Pakistan where new projects of Electrical generation seems impossible, one should adopt such means so as to minimize the power consumption via load management. In this paper a relatively better Electrical power system is proposed for University of Gujrat (UOG) power system. UOG runs its all generators whether it is full load or merely a load of 20 percent as a standby power. It is suggested that if generators system is synchronized and connected in parallel, it can not only minimize the cost, number of personnel required but also increase the reliability of the system. ETAP software is used for simulation and results show that by adopting this method generation cost can be reduced up to 30 percent which is indeed a huge figure. Losses and cable parameters were calculated using this software and found this proposal quite feasible

Overlapping Residual Herbicides for Control of Photosystem (PS) II- and 4-Hydroxyphenylpyruvate Dioxygenase (HPPD)-Inhibitor-Resistant Palmer amaranth (\u3ci\u3eAmaranthus palmeri\u3c/i\u3e S. Watson) in Glyphosate-Resistant Maize

A Palmer amaranth (Amaranthus palmeri S. Watson) biotype has evolved resistance to photosystem (PS) II- (atrazine) and 4-hydroxyphenylpyruvate dioxygenase (HPPD)-inhibiting herbicides (mesotrione, tembotrione, and topramezone) in maize seed production field in Nebraska, USA. The objectives of this study were to determine the effect of soil residual pre-emergence (PRE) herbicides followed by (fb) tank-mixture of residual and foliar active post-emergence (POST) herbicides on PS-II- and HPPD-inhibitor-resistant Palmer amaranth control, maize yield, and net economic returns. Field experiments were conducted in a grower’s field infested with PS II- and HPPD-inhibitor-resistant Palmer amaranth near Shickley in Fillmore County, Nebraska, USA in 2015 and 2016. The contrast analysis suggested that saflufenacil plus dimethenamid-P or pyroxasulfone plus saflufenacil applied PRE provided 80–82% Palmer amaranth control compared to 65 and 39% control with saflufenacil and pyroxasulfone applied alone at 3 weeks after PRE (WAPRE), respectively. Among the PRE fb POST herbicide programs, 95–98% Palmer amaranth control was achieved with pyroxasulfone plus safluefenacil, or saflufenacil plus dimethenamid-P applied PRE, fb glyphosate plus topramezone plus dimethenamid-P plus atrazine, glyphosate plus diflufenzopyr plus dicamba plus pyroxasulfone, glyphosate plus diflufenzopyr plus pendimethalin, or glyphosate plus diflufenzopyr plus dicamba plus atrazine applied POST at 3 weeks after POST (WAPOST) through maize harvest. Based on contrast analysis, PRE fb POST programs provided 77–83% Palmer amaranth control at 3 WAPOST through maize harvest compared to 12–15% control with PRE-only and 66–84% control with POST-only programs. Similarly, PRE fb POST programs provided 99% biomass reduction at 6 WAPOST compared to PRE-only (28%) and POST-only (87%) programs. PRE fb POST programs provided higher maize yield (13,617 kg ha−1) and net return (US $1,724 ha−1) compared to the PRE-only (2,656 kg ha−1; US$285 ha−1) and POST-only (11,429 kg ha−1; US $1,539 ha−1) programs. The results indicated that effective control of multiple herbicide-resistant Palmer amaranth can be achieved with PRE fb POST programs that include herbicides with overlapping residual activity to maintain season-long control

Metabolic engineering and thermodynamic characterization of an extracellular β-glucosidase produced by Aspergillus niger

The production of an extracellular β-glucosidase by Aspergillus niger NRRL 599 was optimized using submerged fermentation technique. Effect of different media, different carbon sources, initial pH of the fermentation medium, temperature, incubation period and inoculum size on the production of β- glucosidase enzyme was investigated. A. niger NRRL 599 produced maximum extracellular β- glucosidase (4.48 U/mg) in Eggins and Pugh medium with 1% wheat bran (w/v) at pH 5.5 inoculated with 4% conidial suspension after 96 h of incubation at 30°C. Purified β-glucosidase gave Km and Vmax values of 3.11 mM and 20.83 U/mg respectively for pNPG hydrolysis. The enzyme was optimally active at pH 4.8 and at temperature of 60°C. Thermodynamic parameters, Ea, ΔH and ΔS were found to be 52.17 KJ/mol, 49.90 J/mol.K and -71.69 KJ/mol, respectively. The pKa1 and pKa2 of ionizable groups of active site residues involved in Vmax were calculated to be 4.1 and 6.0 respectively.Key words: β-Glucosidase, Aspergillus niger, kinetics, thermodynamics

Validation of a computational model for a coupled liquid and gas flow in micro-nozzles

The work presents verification of a numerical model for micro-jet focusing, where a coupled liquid and gas flow occurs in a gas dynamic virtual nozzle (GDVN). Nozzles of this type are used in serial femtosecond crystallography experiments to deliver samples into X-ray beam. The following performance criteria are desirable: the jet to be longer than 100 µm to avoid nozzle shadowing, the diameter as small as possible to minimize the background signal, and the jet velocity as high as possible to avoid sample’s double X-ray exposure. Previous comprehensive numerical investigation has been extended to include numerical analysis of the tip jet velocities. These simulations were then compared with the experimental data. The coupled numerical model of a 3D printed GDVN considers a laminar two-phase, Newtonian, compressible flow, which is solved based on the finite volume method discretization and interface tracking with volume of fluid (VOF). The numerical solution is calculated with OpenFOAM based compressible interFoam solver, which uses algebraic formulation of VOF. In experimental setup for model validation a 3D printed GDVN was inserted in a vacuum chamber with two windows used for illumination and visualization. Once the jet was stabilized its velocity was estimated based on a distance a droplet traveled between two consecutive illumination pulses with a known time delay. The experimental and computational study was performed for a constant liquid flow rate of 14 l/min and the gas mass flow rate in the range from 5 mg/min to 25 mg/min. The coupled numerical model reasonably predicts the jet speed and shape as a function of the gas flow

Probing IC/CMB Interpretation for the X-ray knots of AGN through VHE observations

Detection of hard X-ray spectrum from the kilo-parsec scale jet of active galactic nuclei cannot be accounted to the synchrotron emission mechanism from the electron distribution responsible for the radio/optical emission. Alternate explanations are the inverse Compton scattering of cosmic microwave background photons (IC/CMB) or synchrotron emission from a second electron population. When the X-ray emission is interpreted as IC/CMB process, the Compton spectrum peak at GeV energy and were predicted to be the Fermi candidate sources. The non-detection of significant gamma ray flux from these galaxies by Fermi disfavoured the IC/CMB interpretation of the high energy emission. We extend this study to predict the very high energy (VHE) gamma ray emission due to IC/CMB model which can be investigated by Cherenkov Telescope Array(CTA). The model parameters deciding the broadband spectral energy distribution are estimated using analytical approximation of the emissivity functions. The emission model is extrapolated to VHE energy and then compared with the CTAO sensitivity. Particularly, we selected the sources for which the IC/CMB model is not ruled out by initial Fermi observations.Comment: Submitted to MNRAS Main Joura

Detection & Distinction of Colors using Color Sorting Robotic Arm in a Pick & Place Mechanism

Color sorting Robot is one of the useful, costless and fastest systems in Industrial applications to reduce manual working time and provides less human mistake when manual system is undertaken. The objective of this project is to design an efficient, microcontroller based system that pick up right color of objects and put it down at right place to optimize the productivity, minimizing the cost of the products and decreasing human mistakes. The controller used is a PIC Microcontroller (18F452) having high speed performance, low cost and 32 K bytes program memory. It communicates with color sensor TCS 3200 and various motor modules in real time to detect the right color object and to control the arm movement. Designed system can pick objects of 1kG weight and arm can rotate up to 3600 . Also, the use of easily available components reduces the manufacturing and maintenance costs. The design is quite flexible as the software can be changed according to specific requirements of the user. This makes the proposed system to be an economical, portable and a low maintenance solution for industrial applications

Efficient design for smart environment using Raspberry Pi with Blockchain and IoT (BRIoT)

Internet of Things (IoT) is reshaping digital world day by day by integrating several technologies to provide smart services. However, intrinsic features of IoT resulting in a number of challenges, such as decentralization, poor interoperability, privacy, confidentiality, and security vulnerabilities. Several security techniques like encryption, third-party software’s are in use currently to protect users data. Blockchain was initially established for digital crypto currencies with a Proof of Work (PoW) consensus process and the advantage of smart contracts, which enabled distributed trust without the involvement of a third party. Its distributed trust concept paved the way for many other developments, such as the development of new consensus mechanisms such as Proof of Stake (PoS) and Proof of Authority (PoA), which aided in the adoption of Blockchain with low computation machines into sectors such as smart industry and smart transportation. Blockchain implementation in IoT can address the security issue, here we proposed a design using Raspberry Pi as edge node (BRIoT)