1,897 research outputs found
Time series aggregation, disaggregation and long memory
We study the aggregation/disaggregation problem of random parameter AR(1)
processes and its relation to the long memory phenomenon. We give a
characterization of a subclass of aggregated processes which can be obtained
from simpler, "elementary", cases. In particular cases of the mixture
densities, the structure (moving average representation) of the aggregated
process is investigated
High level of telomerase RNA gene expression is associated with chromatin modification, the ALT phenotype and poor prognosis in liposarcoma
Telomere length is maintained by two known mechanisms, activation of telomerase or alternative lengthening of telomeres (ALT). The ALT pathway is more commonly activated in tumours of mesenchymal origin, although the mechanisms involved in the decision of a cell to activate either telomerase or ALT are unknown at present and no molecular markers exist to define the ALT phenotype. We have previously shown an association between chromatin remodelling, telomerase gene expression and ALT in cell line models. Here, we evaluate these findings and investigate their prognostic significance in a panel of liposarcoma tissue samples to understand the biology underlying the ALT phenotype. Liposarcoma samples were split into three groups: telomerase positive (Tel+); ALT positive; ALT−/Tel−. Differences in telomerase gene expression were evident between the groups with increased expression of hTR in ALT and Tel+ compared to ALT−/Tel− samples and increased hTERT in Tel+ samples only. Investigation of a small panel of chromatin modifications revealed significantly increased binding of acetyl H3 in association with hTR expression. We confirm that the presence of the ALT phenotype is associated with poor prognosis and in addition, for the first time, we show a direct association between hTR expression and poor prognosis in liposarcoma patients
On dilatation operator for a renormalizable theory
Given a renormalizable theory we construct the dilatation operator, in the
sense of generator of RG flow of composite operators. The generator is found as
a differential operator acting on the space of normal symbols of composite
operators in the theory. In the spirit of AdS/CFT correspondence, this operator
is interpreted as the Hamiltonian of the dual theory. In the case of a field
theory with non-abelian gauge symmetry the resulting system is a matrix model.
The one-loop case is analyzed in details and it is shown that we reproduce
known results from N=4 supersymmetric Yang-Mills theory.Comment: 26 pages, no figure
Mastering the Master Space
Supersymmetric gauge theories have an important but perhaps under-appreciated
notion of a master space, which controls the full moduli space. For
world-volume theories of D-branes probing a Calabi-Yau singularity X the
situation is particularly illustrative. In the case of one physical brane, the
master space F is the space of F-terms and a particular quotient thereof is X
itself. We study various properties of F which encode such physical quantities
as Higgsing, BPS spectra, hidden global symmetries, etc. Using the plethystic
program we also discuss what happens at higher number N of branes. This letter
is a summary and some extensions of the key points of a longer companion paper
arXiv:0801.1585.Comment: 10 pages, 1 Figur
M2-Branes and Fano 3-folds
A class of supersymmetric gauge theories arising from M2-branes probing
Calabi-Yau 4-folds which are cones over smooth toric Fano 3-folds is
investigated. For each model, the toric data of the mesonic moduli space is
derived using the forward algorithm. The generators of the mesonic moduli space
are determined using Hilbert series. The spectrum of scaling dimensions for
chiral operators is computed.Comment: 128 pages, 39 figures, 42 table
The spinorial geometry of supersymmetric backgrounds
We propose a new method to solve the Killing spinor equations of
eleven-dimensional supergravity based on a description of spinors in terms of
forms and on the Spin(1,10) gauge symmetry of the supercovariant derivative. We
give the canonical form of Killing spinors for N=2 backgrounds provided that
one of the spinors represents the orbit of Spin(1,10) with stability subgroup
SU(5). We directly solve the Killing spinor equations of N=1 and some N=2, N=3
and N=4 backgrounds. In the N=2 case, we investigate backgrounds with SU(5) and
SU(4) invariant Killing spinors and compute the associated spacetime forms. We
find that N=2 backgrounds with SU(5) invariant Killing spinors admit a timelike
Killing vector and that the space transverse to the orbits of this vector field
is a Hermitian manifold with an SU(5)-structure. Furthermore, N=2 backgrounds
with SU(4) invariant Killing spinors admit two Killing vectors, one timelike
and one spacelike. The space transverse to the orbits of the former is an
almost Hermitian manifold with an SU(4)-structure and the latter leaves the
almost complex structure invariant. We explore the canonical form of Killing
spinors for backgrounds with extended, N>2, supersymmetry. We investigate a
class of N=3 and N=4 backgrounds with SU(4) invariant spinors. We find that in
both cases the space transverse to a timelike vector field is a Hermitian
manifold equipped with an SU(4)-structure and admits two holomorphic Killing
vector fields. We also present an application to M-theory Calabi-Yau
compactifications with fluxes to one-dimension.Comment: Latex, 54 pages, v2: clarifications made and references added. v3:
minor changes. v4: minor change
A Note on Supersymmetric Type II Solutions of Lifshitz Type
We discuss a class of supersymmetric type II non-relativistic solutions with
exact or asymptotic scale invariance. As already emerged from previous
investigations, we find a clear correspondence between anisotropic
d-dimensional vacua and relativistic solutions in (d + 1)-dimensions. We will
show that supersymmetric four-dimensional Poincare' invariant backgrounds in
type IIB can descend to analogous solutions with anisotropic scaling in t and
(x, y). This result can be applied to scale invariant theories, domain walls
interpolating between four-dimensional Lifshitz vacua and more general
solutions with only asymptotic or approximate scaling behaviour.Comment: Added subsection on hyperscaling violation example
Old Inflation in String Theory
We propose a stringy version of the old inflation scenario which does not
require any slow-roll inflaton potential and is based on a specific example of
string compatification with warped metric. Our set-up admits the presence of
anti-D3-branes in the deep infrared region of the metric and a false vacuum
state with positive vacuum energy density. The latter is responsible for the
accelerated period of inflation. The false vacuum exists only if the number of
anti-D3-branes is smaller than a critical number and the graceful exit from
inflation is attained if a number of anti-D3-branes travels from the
ultraviolet towards the infrared region. The cosmological curvature
perturbation is generated through the curvaton mechanism.Comment: 31 pages, 3 figures; typos corrected and reference adde
MiR-1227 targets SEC23A to regulate the shedding of large extracellular vesicles
Cancer cells shed a heterogenous mixture of extracellular vesicles (EVs), differing in both size and composition, which likely influence physiological processes in different manners. However, how cells differentially control the shedding of these EV populations is poorly understood. Here, we show that miR-1227, which is enriched in prostate cancer EVs, compared to the cell of origin, but not in EVs derived from prostate benign epithelial cells, induces the shedding of large EVs (such as large oncosomes), while inhibiting the shedding of small EVs (such as exosomes). RNA sequencing from cells stably expressing miR-1227, a modified RISCTRAP assay that stabilizes and purifies mRNA-miR-1227 complexes for RNA sequencing, and in silico target prediction tools were used to identify miR-1227 targets that may mediate this alteration in EV shedding. The COPII vesicle protein SEC23A emerged and was validated by qPCR, WBlot, and luciferase assays as a direct target of miR-1227. The inhibition of SEC23A was sufficient to induce the shedding of large EVs. These results identify a novel mechanism of EV shedding, by which the inhibition of SEC23A by miR-1227 induces a shift in EV shedding, favoring the shedding of large EV over small EV
Mesonic Chiral Rings in Calabi-Yau Cones from Field Theory
We study the half-BPS mesonic chiral ring of the N=1 superconformal quiver
theories arising from N D3-branes stacked at Y^pq and L^abc Calabi-Yau conical
singularities. We map each gauge invariant operator represented on the quiver
as an irreducible loop adjoint at some node, to an invariant monomial, modulo
relations, in the gauged linear sigma model describing the corresponding bulk
geometry. This map enables us to write a partition function at finite N over
mesonic half-BPS states. It agrees with the bulk gravity interpretation of
chiral ring states as cohomologically trivial giant gravitons. The quiver
theories for L^aba, which have singular base geometries, contain extra
operators not counted by the naive bulk partition function. These extra
operators have a natural interpretation in terms of twisted states localized at
the orbifold-like singularities in the bulk.Comment: Latex, 25pgs, 12 figs, v2: minor clarification
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