Soundtracks and the moving image

This study is a survey and analysis of modern soundtrack pieces accompanying recent movies. I will analyze the form and chord progressions within the scores to better understand the role each musical element plays in the piece. Then, I will compare these details to find common themes to see if they correspond more to the Western classical tradition, or to modern pop music, and how each textural element enhances its visual counterpart. This paper is an attempt to define and understand the formal procedures are common across the audio that accompanies modern movies

Laboratory driven, lean-to-adaptive prototyping in Parallel for Web software project identification and application development in health science research

Journal ArticleClinical research laboratories, bioinformatics core facilities, and health science organizations often rely on heavy planning based software development models to propose, build, and distribute software as a consumable product. Projects in non-agile software life cycles tend to have rigid ?plan-design-build? milestones, increasing the amount of time needed for software development completion. Though the classic software development approach is needed for large-scale and organizational projects, clinical research laboratories can expedite software development while maintaining quality by using lean prototyping as a condition of project advancement to a committed adaptive software development cycle. Software projects benefit from an agile methodology due to the active and changing requirements often guided by experimental data driven models. We describe a lean to adaptive method used in parallel with laboratory bench work to develop quality software quickly that meets the requirements of a fast-paced research environment and reducing time to production, providing immediate value to the end user, and limiting unnecessary development practices in favor of results

White Rage, Black Agency: Violence and its Impact on Reconstruction Era Florida

The Reconstruction era in Florida is often misunderstood. Historians generally focus on the Civil War and the post-Reconstruction era to emphasize how the South has changed, but the Reconstruction era remains in shadow. To rectify this gap, this research provides more information about the Reconstruction era in Florida, specifically the impact of violence. To achieve this, I primarily used the testimonies gathered from the Joint Select Committee\u27s investigation of violence during the Reconstruction era and the testimonies given to the Federal Government after the 1876 Presidential Election. The testimonies in these documents allow me to demonstrate how conservative whites used violence to reestablish white supremacy after the passage of the 13th, 14th, and 15th Amendments. This study affirms that the violence exhibited during the Reconstruction era significantly impacted People of Color and white Republicans and changed the course of Florida history. This study is critical because it connects the lawlessness of the territorial days of Florida before the Civil War to the organized and targeted violence of the Reconstruction era, which lived on well into the 20th century. While this study builds upon what modern scholars have dubbed one of the most progressive eras in history, it also exposes the reality of day-to-day life in Reconstruction era Florida, which was rife with bloodshed and disorder for People of Color and white Republicans

Going Global: Interest in Global Health among US Otolaryngology Residents

Background: To meet the rising interest in surgical global health, some surgical residency programs offer global health experiences. The level of interest in these programs, however, and their role in residency recruitment and career planning has not been systematically evaluated. Objective: (1) Define interest in global health among Otolaryngology residents in the USA. (2) Assess engagement of Otolaryngology residencies in global health training. (3) Determine barriers to global health training in residency. Methods: A survey questionnaire was developed and sent to all Otolaryngology Residency Program Directors for distribution to all current Otolaryngology residents in the US. Results: A total of 91 complete surveys were collected. A majority of respondents felt that global health was either very important or extremely important (67%). Two-thirds of respondents had prior global health experience (68%). While 56% of respondents would definitely participate in a global health elective and 78% would likely or definitely participate, only 37% of residency programs offered a global health experience. The availability of a global health elective significantly correlated with residency match choice in respondents with previous global health experience. The three most common barriers to participation were insufficient time, insufficient funding, and lack of program. Conclusion: Participation in bilateral and equitable international electives is a unique experience of personal and professional growth. There is an interest in these opportunities during residency training among Otolaryngology residents that is not reflected in availability within training programs. This suggests the need for development of humanitarian outreach exposure through global health experiences during surgical residency training

Indirect Detection of Secluded Supersymmetric Dark Matter

Weak-scale secluded sector dark matter can reproduce the observed dark matter relic density with thermal freeze-out within that sector. If nature is supersymmetric, three portals to the visible sector - a gauge portal, a Higgs portal, and a gaugino portal - are present. We present gamma ray spectra relevant for indirect detection of dark matter annihilation in such setups. Since symmetries in the secluded sector can stabilize dark matter, $R$-parity is unnecessary, and we investigate the impact of $R$-parity violation on annihilation spectra. We present limits from the Fermi Large Area Telescope observations of dwarf galaxies and projections for Cherenkov Telescope Array observations of the galactic center. Many of our results are also applicable to generic, non-supersymmetric setups.Comment: 30 pages, 10 figure

“I Notice My Feelings:” Exploring Mindfulness with 1st Graders and their Families

This paper explores a study completed with 1st grade students while a five-week mindfulness unit was implemented in their classroom. The paper discusses tactics for teaching mindfulness strategies to students and results observed in the students over the course of the five-week study. It also contains journal entries completed by students and their families both in the classroom and at home

Galaxy interactions in IllustrisTNG-100, I: The power and limitations of visual identification

We present a sample of 446 galaxy pairs constructed using the cosmological simulation IllustrisTNG-100 at z = 0, with M_(FoF,dm)=10¹¹−10^(13.5) M⊙. We produce ideal mock SDSS g-band images of all pairs to test the reliability of visual classification schema employed to produce samples of interacting galaxies. We visually classify each image as interacting or not based on the presence of a close neighbour, the presence of stellar debris fields, disturbed discs, and/or tidal features. By inspecting the trajectories of the pairs, we determine that these indicators correctly identify interacting galaxies ∼45 per cent of the time. We subsequently split the sample into the visually identified interacting pairs (VIP; 38 pairs) and those which are interacting but are not visually identified (nonVIP; 47 pairs). We find that VIP have undergone a close passage nearly twice as recently as the non-VIP, and typically have higher stellar masses. Further, the VIP sit in dark matter haloes that are approximately 2.5 times as massive, in environments nearly 2 times as dense, and are almost a factor of 10 more affected by the tidal forces of their surroundings than the nonVIP. These factors conspire to increase the observability of tidal features and disturbed morphologies, making the VIP more likely to be identified. Thus, merger rate calculations which rely on stellar morphologies are likely to be significantly biased toward massive galaxy pairs which have recently undergone a close passage

Development and Validation of eRADAR: A Tool Using EHR Data to Detect Unrecognized Dementia.

ObjectivesEarly recognition of dementia would allow patients and their families to receive care earlier in the disease process, potentially improving care management and patient outcomes, yet nearly half of patients with dementia are undiagnosed. Our aim was to develop and validate an electronic health record (EHR)-based tool to help detect patients with unrecognized dementia (EHR Risk of Alzheimer's and Dementia Assessment Rule [eRADAR]).DesignRetrospective cohort study.SettingKaiser Permanente Washington (KPWA), an integrated healthcare delivery system.ParticipantsA total of 16 665 visits among 4330 participants in the Adult Changes in Thought (ACT) study, who undergo a comprehensive process to detect and diagnose dementia every 2 years and have linked KPWA EHR data, divided into development (70%) and validation (30%) samples.MeasurementsEHR predictors included demographics, medical diagnoses, vital signs, healthcare utilization, and medications within the previous 2 years. Unrecognized dementia was defined as detection in ACT before documentation in the KPWA EHR (ie, lack of dementia or memory loss diagnosis codes or dementia medication fills).ResultsOverall, 1015 ACT visits resulted in a diagnosis of incident dementia, of which 498 (49%) were unrecognized in the KPWA EHR. The final 31-predictor model included markers of dementia-related symptoms (eg, psychosis diagnoses, antidepressant fills), healthcare utilization pattern (eg, emergency department visits), and dementia risk factors (eg, cerebrovascular disease, diabetes). Discrimination was good in the development (C statistic = .78; 95% confidence interval [CI] = .76-.81) and validation (C statistic = .81; 95% CI = .78-.84) samples, and calibration was good based on plots of predicted vs observed risk. If patients with scores in the top 5% were flagged for additional evaluation, we estimate that 1 in 6 would have dementia.ConclusionThe eRADAR tool uses existing EHR data to detect patients with good accuracy who may have unrecognized dementia. J Am Geriatr Soc 68:103-111, 2019

Using Gene Expression Signatures to Identify Novel Treatment Strategies in Gulf War Illness

Background Gulf War Illness (GWI) is a complex multi-symptom disorder that affects up to one in three veterans of this 1991 conflict and for which no effective treatment has been found. Discovering novel treatment strategies for such a complex chronic illness is extremely expensive, carries a high probability of failure and a lengthy cycle time. Repurposing Food and Drug Administration approved drugs offers a cost-effective solution with a significantly abbreviated timeline. Methods Here, we explore drug re-purposing opportunities in GWI by combining systems biology and bioinformatics techniques with pharmacogenomic information to find overlapping elements in gene expression linking GWI to successfully treated diseases. Gene modules were defined based on cellular function and their activation estimated from the differential expression of each module’s constituent genes. These gene modules were then cross-referenced with drug atlas and pharmacogenomic databases to identify agents currently used successfully for treatment in other diseases. To explore the clinical use of these drugs in illnesses similar to GWI we compared gene expression patterns in modules that were significantly expressed in GWI with expression patterns in those same modules in other illnesses. Results We found 19 functional modules with significantly altered gene expression patterns in GWI. Within these modules, 45 genes were documented drug targets. Illnesses with highly correlated gene expression patterns overlapping considerably with GWI were found in 18 of the disease conditions studied. Brain, muscular and autoimmune disorders composed the bulk of these. Conclusion Of the associated drugs, immunosuppressants currently used in treating rheumatoid arthritis, and hormone based therapies were identified as the best available candidates for treating GWI symptoms